A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
Bin Cao, Yeming Wang, Danning Wen, Wen Liu, Jingli Wang, Guohui Fan, Lianguo Ruan, Bin Song, Yanping Cai, Ming Wei, Xingwang Li, Jiaan Xia, Nanshan Chen, Jie Xiang, Ting Yu, Tao Bai, Xuelei Xie, Li Zhang, Caihong Li, Ye Yuan, Hua Chen, Huadong Li, Hanping Huang, Shengjing Tu, Fengyun Gong, Ying Liu, Yuan Wei, Chongya Dong, Fei Zhou, Xiaoying Gu, Jiuyang Xu, Zhibo Liu, Yi Zhang, Hui Li, Lianhan Shang, Ke Wang, Kunxia Li, Xia Zhou, Xuan Dong, Zhaohui Qu, Sixia Lu, Xujuan Hu, Shunan Ruan, Shanshan Luo, Jing Wu, Lu Peng, Fang Cheng, Lihong Pan, Jun Zou, Chunmin Jia, Juan Wang, Xia Liu, Shuzhen Wang, Xudong Wu, Qin Ge, Jing He, Haiyan Zhan, Fang Qiu, Li Guo, Chaolin Huang, Thomas Jaki, Frederick G Hayden, Peter W Horby, Dingyu Zhang, Chen Wang
New England Journal of Medicine, doi:10.1056/nejmoa2001282
2.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. We thank all patients who participated in this trial and their families. We also thank Bandar Al Knawy and Yaseen Arabi for shar-ing the MIRACLE trial documentation and meeting reports from WHO Novel Coronavirus R&D. Teddy Clinical Research Laboratory (Shanghai) served as the central laboratory, and Roche Diag nostics (Shanghai) provided instruments and SARS-CoV-2 assay detection. We dedicate this work to the memory of health care workers who have given their lives in the care of patients with Covid-19. L., Yuan Wei, K.W., K.L., X.Z., X.D., Z.Q., Sixia Lu, X.H., S.R., Shanshan Luo, Jing Wu, Lu Peng, F.C., Lihong Pan, J.Z., C.J., Juan Wang, Xia Liu, S.W., X.W., Q.G., J.H., H.Z., F.Q., C.H., D.Z.) -all in China; Lancaster University, Lancaster (T.J.), and the University of Oxford, Oxford (P.W.H.) -both in the United Kingdom; and the University of Virginia School of Medicine, Charlottesville (F.G.H.).
Appendix
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