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0 0.5 1 1.5 2+ Recovery time 77% Improvement Relative Risk Recovery time (b) 83% Time to viral- 38% c19early.org/aa Cadegiani et al. Spironolactone for COVID-19 EARLY Is early treatment with antiandrogens beneficial for COVID-19? Prospective study of 270 patients in Brazil Faster recovery (p=0.0062) and viral clearance (p=0.015) Cadegiani et al., medRxiv, doi:10.1101/2020.10.05.20206870 Favors spironolactone Favors control
An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial
Cadegiani et al., medRxiv, doi:10.1101/2020.10.05.20206870 (Preprint)
Cadegiani et al., An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological.., medRxiv, doi:10.1101/2020.10.05.20206870 (Preprint)
Oct 2020   Source   PDF  
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Prospective study of 270 female COVID-19 patients in Brazil, 75 with hyperandrogenism, of which 8 were on spironolactone. Results suggest that HA patients may be at increased risk, and that spironolactone use may reduce the risk compared to both other HA patients and non-HA patients. SOC included other treatments and there was no mortality or hospitalization. This study is excluded in the after exclusion results of meta analysis: significant unadjusted differences between groups.
recovery time, 76.7% lower, relative time 0.23, p = 0.006, treatment 8, control 262, excluding anosmia.
recovery time, 82.8% lower, relative time 0.17, p = 0.002, treatment 8, control 262, including anosmia.
time to viral-, 37.9% lower, relative time 0.62, p = 0.02, treatment 8, control 262.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cadegiani et al., 6 Oct 2020, prospective, Brazil, preprint, 4 authors, average treatment delay 3.0 days.
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Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.10.05.20206870; this version posted October 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license . An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. Flavio A. Cadegiani1,2, Andy Goren3, Carlos G. Wambier4, John McCoy3 1 Adrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil 2 Corpometria Institute, Brasília, DF, Brazil 3 Applied Biology Inc., Irvine, CA, USA 4 Brown University, RI, USA Address correspondence: Flavio A. Cadegiani, MD, MSc, PhD Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo Rua Pedro de Toledo 781 – 13th floor, 04039-032 São Paulo, SP – Brazil Email: flavio.cadegiani@unifesp.br ; f.cadegiani@gmail.com Telephone: +55 61 996506111, Fax: +55 61 33464733 Key-words: COVID-19, SARS-CoV-2, antiandrogen, dutasteride, spironolactone, Abstract Background: While COVID-19 remains largely unclear and mortality continues to raise, early effective approaches prior to complications lack, as well as researches for characterization and therapeutical potential options in actual early COVID-19. Although females seem to be less affected than females, hyperandrogenic (HA) phenotype, like polycystic ovary syndrome (PCOS), idiopathic hirsutism, congenital adrenal hyperplasia (CAH) female androgenetic alopecia (AGA), or idiopathic HA may be at higher risk due to its inherent enhanced androgenic activity. The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.10.05.20206870; this version posted October 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license . before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Patients were questioned for baseline characteristics, 23 different diseases, 44 drug classes and vaccines, 28 different symptoms, and eight different parameters to measure COVID-19 related clinical outcomes. Treatment was then provided, including azithromycin 500mg/day for five days in all cases, associated with hydroxychloroquine 400mg/day for five days, nitazoxanide 500mg twice a day for six days, or ivermectin 0.2mg/kg/day por three days, and optionally spironolactone 100mg twice a day until cure. Patients were assessed for COVID-19 clinical course, clinical and viral duration,..
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