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Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers

Bundgaard et al., Annals of Internal Medicine, doi:10.7326/M20-6817 , DANMASK-19, NCT04337541
Nov 2020  
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Case 18% Improvement Relative Risk PPE  DANMASK-19  Prophylaxis  RCT Does PPE reduce COVID-19 infections? RCT 4,862 patients in Denmark (April - May 2020) Fewer cases with PPE (not stat. sig., p=0.33) c19early.org Bundgaard et al., Annals of Internal M.., Nov 2020 FavorsPPE Favorscontrol 0 0.5 1 1.5 2+
RCT 4,862 community-dwelling adults in Denmark, showig no significant difference in COVID-19 cases with recommending the use of surgical masks outside the home. The prespecified mortality outcomes are not reported and the only severity information provided is symptom counts.
risk of case, 18.0% lower, RR 0.82, p = 0.33, treatment 42 of 2,392 (1.8%), control 53 of 2,470 (2.1%), NNT 256.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bundgaard et al., 18 Nov 2020, Randomized Controlled Trial, Denmark, peer-reviewed, 22 authors, study period 6 April, 2020 - 9 May, 2020, trial NCT04337541 (history) (DANMASK-19).
This PaperPPEAll
Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers
DMSc Henning Bundgaard, Johan Skov Bundgaard, Daniel Emil Tadeusz Raaschou-Pedersen, DMSc Christian Von Buchwald, MD Tobias Todsen, MD; Jakob Boesgaard Norsk, MD Mia M Pries-Heje, Christoffer Rasmus Vissing, MD Pernille B Nielsen, MD Ulrik C Winsløw, MD; Kamille Fogh, MD Rasmus Hasselbalch, MD Jonas H Kristensen, PhD Anna Ringgaard, Mikkel Porsborg Andersen, PhD Nicole Bakkegård Goecke, PhD Ramona Trebbien, PhD Kerstin Skovgaard, DMSc Thomas Benfield, PhD Henrik Ullum, DMSc Christian Torp-Pedersen, DMSc Kasper Iversen
Annals of Internal Medicine, doi:10.7326/m20-6817
Background: Observational evidence suggests that mask wearing mitigates transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is uncertain if this observed association arises through protection of uninfected wearers (protective effect), via reduced transmission from infected mask wearers (source control), or both. Objective: To assess whether recommending surgical mask use outside the home reduces wearers' risk for SARS-CoV-2 infection in a setting where masks were uncommon and not among recommended public health measures.
Inclusion and exclusion criteria are described in the Methods section, and criteria for completion of the study are given in the Supplement (available at Annals.org). SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2. ORIGINAL RESEARCH Effectiveness of Mask Recommendation for Preventing SARS-CoV-2 Infection
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