Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The relationship between vitamin D, biomarkers and clinical outcome in hospitalised Covid-19 patients

Breslin et al., Proceedings of the Nutrition Society, doi:10.1017/S0029665121002214
Aug 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Progression 56% Improvement Relative Risk Vitamin D for COVID-19  Breslin et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 138 patients in Ireland Lower progression with higher vitamin D levels (p=0.026) c19early.org Breslin et al., Proceedings of the Nut.., Aug 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Retrospective 138 COVID-19 hospitalized patients in Ireland, showing increased risk of infiltrates on chest X-ray for patients with vitamin D deficiency, and lower vitamin D levels in patients that died (21.8 nmol/L vs. 37.8 nmol/L, p = 0.054).
This is the 91st of 204 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 107,767,362 vigintillion).
risk of progression, 55.6% lower, OR 0.44, p = 0.03, high D levels (≥30nmol/l) 106, low D levels (<30nmol/l) 32, adjusted per study, inverted to make OR<1 favor high D levels (≥30nmol/l), infiltrates on chest X-ray, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Breslin et al., 17 Aug 2021, retrospective, Ireland, peer-reviewed, 4 authors.
This PaperVitamin DAll
The relationship between vitamin D, biomarkers and clinical outcome in hospitalised Covid-19 patients
É Breslin, D Mccartney, C Nícheallaigh, D Byrne
Proceedings of the Nutrition Society, doi:10.1017/s0029665121002214
Previous research has identified an association between low vitamin D status and the risk and severity of acute respiratory infections 1, 2 , leading to suggestion that correction of vitamin D deficiency may improve outcome in COVID-19 patients. This study aimed to elucidate the association between low vitamin D status and adverse clinical outcomes including mortality amongst Covid-19 inpatients. Two-hundred participants were recruited from St. James Hospital, Dublin. Indices of disease severity included duration of hospitalisation, number of signs and symptoms experienced, requirement for oxygen support and ICU admission and mortality. Pearson's and Spearman's correlation tests were used to evaluate the association between serum vitamin D (25(OH)D), interleukin-6 (IL-6), D-dimer, fibrinogen and CD25 levels and disease outcome. Overall, 138 patients (69%) had measured 25(OH)D levels; 23% (n = 32) were classified as 'deficient' (25(OH)D < 30 nmol/L), 25% (n = 34) were classified as 'insufficient' (25(OH)D of 30-49.9 nmol/L) and 52% (n = 72) were classified as 'sufficient' (25(OH)D ≥ 50 nmol/l). No significant correlation was observed between circulating 25(OH)D and age. However, serum 25(OH)D was inversely associated with IL-6 (Β = -0.696, p = 0.036) and D-dimer (Β = -13.71, p = 0.002). High IL-6 levels were associated with an increased likelihood of infiltrates on chest X-ray (OR = 3.615, p = 0.044), while high D-Dimer levels were associated with an increased risk of admission to ICU (OR = 15.304, p = 0.012), and an increased likelihood of requiring oxygen support (OR = 4.035, p = 0.004). Clinically, vitamin D deficiency was associated with an increased risk of infiltrates on chest X-ray (OR = 2.253, p = 0.026). There was also a tendency towards lower vitamin D levels in patients who died (n = 15) than in those who survived (n = 123) (21.8 nmol/L vs. 37.8 nmol/L, p = 0.054). These data suggest that low vitamin D status may be associated with poorer clinical and biometric profiles and increased mortality in hospitalised Covid-19 patients. The association of low vitamin D status with higher IL-6 and higher D-dimer levels, and the association of these biometric markers with more severe clinical outcomes in this and other studies (3, 4) , suggest that these pro-inflammatory and pro-thrombotic mediators may lie at an intermediate point in the causal pathway between low vitamin D status and poorer clinical outcomes including mortality in hospitalised Covid-19 patients.
References
Baktash, Hosack, None, Postgrad Med J
Jain, Chaurasia, None
Martineau, Jolliffe, None, BMJ
Xu, Yang, None, Mol Med Rep
{ 'indexed': { 'date-parts': [[2022, 11, 30]], 'date-time': '2022-11-30T07:28:18Z', 'timestamp': 1669793298592}, 'reference-count': 4, 'publisher': 'Cambridge University Press (CUP)', 'issue': 'OCE3', 'license': [ { 'start': { 'date-parts': [[2021, 8, 17]], 'date-time': '2021-08-17T00:00:00Z', 'timestamp': 1629158400000}, 'content-version': 'unspecified', 'delay-in-days': 228, 'URL': 'https://www.cambridge.org/core/terms'}], 'content-domain': {'domain': ['cambridge.org'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2021]]}, 'DOI': '10.1017/s0029665121002214', 'type': 'journal-article', 'created': {'date-parts': [[2021, 8, 17]], 'date-time': '2021-08-17T09:18:12Z', 'timestamp': 1629191892000}, 'update-policy': 'http://dx.doi.org/10.1017/policypage', 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': 'The relationship between vitamin D, biomarkers and clinical outcome in hospitalised Covid-19 ' 'patients', 'prefix': '10.1017', 'volume': '80', 'author': [ {'given': 'É.', 'family': 'Breslin', 'sequence': 'first', 'affiliation': []}, {'given': 'D.', 'family': 'McCartney', 'sequence': 'additional', 'affiliation': []}, {'given': 'C.', 'family': 'NíCheallaigh', 'sequence': 'additional', 'affiliation': []}, {'given': 'D.', 'family': 'Byrne', 'sequence': 'additional', 'affiliation': []}], 'member': '56', 'published-online': {'date-parts': [[2021, 8, 17]]}, 'reference': [ { 'key': 'S0029665121002214_ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41598-020-77093-z'}, { 'key': 'S0029665121002214_ref4', 'first-page': '26', 'author': 'Baktash', 'year': '2020', 'journal-title': 'Postgrad Med J'}, { 'key': 'S0029665121002214_ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.3892/mmr.2017.7546'}, { 'key': 'S0029665121002214_ref1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.i6583'}], 'container-title': 'Proceedings of the Nutrition Society', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0029665121002214', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 10, 15]], 'date-time': '2021-10-15T15:58:20Z', 'timestamp': 1634313500000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.cambridge.org/core/product/identifier/S0029665121002214/type/journal_article'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021]]}, 'references-count': 4, 'journal-issue': {'issue': 'OCE3', 'published-print': {'date-parts': [[2021]]}}, 'alternative-id': ['S0029665121002214'], 'URL': 'http://dx.doi.org/10.1017/S0029665121002214', 'relation': {}, 'ISSN': ['0029-6651', '1475-2719'], 'subject': ['Nutrition and Dietetics', 'Medicine (miscellaneous)'], 'container-title-short': 'Proc. Nutr. Soc.', 'published': {'date-parts': [[2021]]}, 'assertion': [ { 'value': 'Copyright © The Authors 2021', 'name': 'copyright', 'label': 'Copyright', 'group': {'name': 'copyright_and_licensing', 'label': 'Copyright and Licensing'}}], 'article-number': 'E98'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit