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@CovidAnalysis
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Metformin reduces the risk of Long COVID or Death over 6 months in an Emulated Target Trial of Primarily Omicron-infected Adults without Diabetes or Prediabetes: a New-User, Active-Comparator Analysis Using the National COVID Cohort Collaborative (N3C) Electronic Health Record Database. This research was supported in part by the Intramural/Extramural research program of the National Center for Advancing Translational Science, NIH

Bramante et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofae631.016
Jan 2025  
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PASC or death 53% Improvement Relative Risk Metformin  Bramante et al.  EARLY TREATMENT Is early treatment with metformin beneficial for COVID-19? Retrospective 496 patients in the USA Lower PASC with metformin (p=0.021) c19early.org Bramante et al., Open Forum Infectious.., Jan 2025 Favorsmetformin Favorscontrol 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020, now with p < 0.00000000001 from 103 studies.
Lower risk for mortality, ventilation, ICU, hospitalization, progression, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 115 treatments. c19early.org
Emulated target trial of Omicron-infected outpatients without diabetes or prediabetes, showing significantly lower long COVID or death with metformin treatment.
Important missing comments or errors? Let us know.
PASC or death, 53.0% lower, HR 0.47, p = 0.02, treatment 10 of 248 (4.0%), control 21 of 248 (8.5%), NNT 23.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bramante et al., 29 Jan 2025, retrospective, USA, peer-reviewed, 10 authors.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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