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Metformin Use in Patients Hospitalized With COVID-19: Lower Inflammation, Oxidative Stress, and Thrombotic Risk Markers and Better Clinical Outcomes

Bliden et al., Circulation, 144:A12228
Nov 2021  
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Mortality 60% Improvement Relative Risk Ventilation 76% Metformin for COVID-19  Bliden et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 75 patients in the USA Lower mortality (p=0.21) and ventilation (p=0.054), not sig. c19early.org Bliden et al., Circulation, 144:A12228, Nov 2021 Favorsmetformin Favorscontrol 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020, now with p < 0.00000000001 from 99 studies.
Lower risk for mortality, ventilation, ICU, hospitalization, progression, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 75 diabetes patients, 34 on metformin, showing lower mortality with treatment in unadjusted results with minimal group details.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with minimal group details.
Important missing comments or errors? Let us know.
risk of death, 59.8% lower, RR 0.40, p = 0.21, treatment 3 of 34 (8.8%), control 9 of 41 (22.0%), NNT 7.6.
risk of mechanical ventilation, 75.9% lower, RR 0.24, p = 0.05, treatment 2 of 34 (5.9%), control 10 of 41 (24.4%), NNT 5.4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bliden et al., 8 Nov 2021, retrospective, USA, preprint, 9 authors.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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