Metformin Use in Patients Hospitalized With COVID-19: Lower Inflammation, Oxidative Stress, and Thrombotic Risk Markers and Better Clinical Outcomes

Bliden et al., Circulation, 144:A12228 (Preprint)

Bliden et al., Metformin Use in Patients Hospitalized With COVID-19: Lower Inflammation, Oxidative Stress, and Thrombotic.., Circulation, 144:A12228 (Preprint)

Nov 2021 Source PDF

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Retrospective 75 diabetes patients, 34 on metformin, showing lower mortality with treatment in unadjusted results with minimal group details. This study is excluded in the after exclusion results of meta analysis: unadjusted results with minimal group details.

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risk of death, 59.8% lower, RR 0.40, p = 0.21, treatment 3 of 34 (8.8%), control 9 of 41 (22.0%), NNT 7.6.

risk of mechanical ventilation, 75.9% lower, RR 0.24, p = 0.05, treatment 2 of 34 (5.9%), control 10 of 41 (24.4%), NNT 5.4.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Bliden et al., 8 Nov 2021, retrospective, USA, preprint, 9 authors.

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