Does Vitamin D Supplementation Reduce Cytokine Storm and Mortality in Geriatric Intensive Care Patients Diagnosed with COVID-19
Yeliz Bilir, Akın Bilir, Ayten Saracoğlu, Fulya Çiyiltepe, Elif Bombaci, Kemal Tolga Saraçoğlu, Recep Demirhan
Journal of Contemporary Medicine, doi:10.16899/jcm.990057
Introduction: Coronavirus disease progresses from an asymptomatic stage to a fatal stage characterized by a cytokine storm. The present study aimed to emphasize the therapeutic effect of vitamin-D supplementation and its potential importance in reducing the disease severity in older adults in the intensive care unit after COVID-19 diagnosis.
Materials and Method: The data of 80 patients aged ≥ 65 years who followed up in intensive care clinic. The inflammatory parameters and clinical course of 40 patients whose serum 25-hydroxyvitamin-D level was below 30 ng/ml and who received vitamin-D supplementation (case-group) were recorded on the fifth and tenth days of follow-up and compared with those of the other 40 patients 40 patients who vitamin D supplementation was not started because of high vitamin D levels (control-group). Results: Of the 80 patients, 40 (50%) were male and 40 (50%) were female. The mean age of the patients was 72±10.8 years. The mean vitamin D level of the case group was 11.6 ng/ml. On the 10. day levels of the inflammatory markers C-Reactive Protein, Procalcitonin, D-Dimer, Ferritin, Interleukin-6 and Lactate Dehydrogenase were significantly lower and the lymphocyte count was significantly higher in the case group than in the control group. On the 5. day, the interleukin-6 level was significantly lower in the case group. Weaning was performed in nine and four patients in the case and control groups, respectively. There was no significant difference in mortality rates between the groups.
Conclusion: Vitamin-D supplementation can help reduce cytokine response. Recommended prophylactically or therapeutically at all stages of coronavirus disease.
References
Adamo, Yoshikawa, Ouslander, Coronavirus disease 2019 in geriatrics and long-term care:the ABCDs of COVID-19, J Am Geriatr Soc
Alıpıo, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus
Ardizzone, Cassinotti, Trabattoni, Immunomodulatoryeffects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease:an in vitro study, Int J Immunopathol Pharmacol
Autier, Mullie, Macacu, Effect of vitamin D supplementation on non-skeletaldisorders:a systematic review of meta-analyses and randomised trials, Lancet Diabetes Endocrinol
Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J
Beard, Bearden, Striker, Vitamin D and the anti-viral state, J Clin Virol
Binkley, Ramamurthy, Krueger, Low vitamin D status:definition, prevalence, consequences, andcorrection, Endocrinol Metab Clin North Am
Boucher, Theproblems of vitamin d insufficiency in older people, Aging Dis
Conti, Ronconi, Caraffa, Induction of pro-inflammatorycytokines (IL-1 andIL-6) and lung inflammation by Coronavirus-19 (COVID-19 or SARS-CoV-2):anti-inflammatory strategies, J Biol Regul Homeost Agents
Duru, Hastalarda, COVID-19. diğer:Göğüs Hastalıkları Uzmanlarının Bilmesi Gerekenler'başlıklı ek sayısında derlemeyi
Gheblawi, Wang, Viveiros, Angiotensin-Converting Enzyme 2:SARS-CoV-2 Receptorand Regulator of the Renin-Angiotensin System:Celebrating the 20th Anniversary of the Discovery of ACE2, Circ Res
Grant, Baggerly, Lahore, Reply, Vitamin D Supplementation in Influenza and COVID-19 Infections. Comment on:Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Nutrients 2020, 12(4, Nutrients
Greiller, Martineau, Modulation of the immuneresponse to respiratory viruses by vitamin D, Nutrients
Hribar, Cobbold, Church, Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson's Disease, Brain Sci
Liyc, Uskokovic, Vitamin D:a negative endocrine regulator of the renin-angiotensinsystemandbloodpressure, J Steroid Biochem Mol Biol
Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections:systematic review and metaanalysis of individual participant data, BMJ
Panarese, Shahini, Letter:Covid-19, and vitamin D, Aliment Pharmacol Ther
Rhodes, Subramanian, Laird, Editorial:low population mortality from COVID-19 in countriessouth of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment Pharmacol Ther
Teymoori-Rad, Shokri, Salimi, The inter play between vitamin D and viral infections, Rev Med Virol
Thomas, Thadhani, Hypovitaminosis D in medical in patients, N Engl J Med
Trovas, Tournis, Vitamin D and COVID-19, Hormones
Vásárhelyi, Sátori, Olajos, Low vitamin D level samong patients at Semmelweis University:retrospective analysis during a one-year period, Orv Hetil
Wang, Gruttola, Lei, The vitamin D for COVID-19 (VIVID) trial:A pragmatic cluster-randomized design, Contemp Clin Trials
Yan, Zhang, Li, Structural basis for there cognition of SARS-CoV-2 by full-length human ACE2, Science
Zabetakis, Lordan, Norton, COVID-19:The Inflammation Link and the Role of Nutrition in Potential Mitigation, Nutrients
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