Does Vitamin D Supplementation Reduce Cytokine Storm and Mortality in Geriatric Intensive Care Patients Diagnosed with COVID-19
Yeliz Bilir, Akın Bilir, Ayten Saracoğlu, Fulya Çiyiltepe, Elif Bombaci, Kemal Tolga Saraçoğlu, Recep Demirhan
Journal of Contemporary Medicine, doi:10.16899/jcm.990057
Introduction: Coronavirus disease progresses from an asymptomatic stage to a fatal stage characterized by a cytokine storm. The present study aimed to emphasize the therapeutic effect of vitamin-D supplementation and its potential importance in reducing the disease severity in older adults in the intensive care unit after COVID-19 diagnosis.
Materials and Method: The data of 80 patients aged ≥ 65 years who followed up in intensive care clinic. The inflammatory parameters and clinical course of 40 patients whose serum 25-hydroxyvitamin-D level was below 30 ng/ml and who received vitamin-D supplementation (case-group) were recorded on the fifth and tenth days of follow-up and compared with those of the other 40 patients 40 patients who vitamin D supplementation was not started because of high vitamin D levels (control-group). Results: Of the 80 patients, 40 (50%) were male and 40 (50%) were female. The mean age of the patients was 72±10.8 years. The mean vitamin D level of the case group was 11.6 ng/ml. On the 10. day levels of the inflammatory markers C-Reactive Protein, Procalcitonin, D-Dimer, Ferritin, Interleukin-6 and Lactate Dehydrogenase were significantly lower and the lymphocyte count was significantly higher in the case group than in the control group. On the 5. day, the interleukin-6 level was significantly lower in the case group. Weaning was performed in nine and four patients in the case and control groups, respectively. There was no significant difference in mortality rates between the groups.
Conclusion: Vitamin-D supplementation can help reduce cytokine response. Recommended prophylactically or therapeutically at all stages of coronavirus disease.
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