Association of Trace Element Status in COVID-19 Patients with Disease Severity
Bego et al.,
Association of Trace Element Status in COVID-19 Patients with Disease Severity,
Journal of Trace Elements in Medicine and Biology, doi:10.1016/j.jtemb.2022.127055
Analysis of 210 hospitalized patients in Bosnia and Herzegovina with serum levels measured on admission, showing significantly lower zinc and selenium levels in patients that died or had severe cases, compared to mild cases.
Bego et al., 4 Aug 2022, Bosnia and Herzegovina, peer-reviewed, 10 authors, study period January 2021 - July 2021.
Contact:
tamer.bego@ffsa.unsa.ba.
Abstract: Journal Pre-proof
Association of Trace Element Status in COVID-19
Patients with Disease Severity
Tamer Bego, Neven Meseldžić, Besim Prnjavorac,
Lejla Prnjavorac, Damir Marjanović, Rui Azevedo,
Edgar Pinto, Mary Duro, Cristina Couto,
Agostinho Almeida
PII:
S0946-672X(22)00135-3
DOI:
https://doi.org/10.1016/j.jtemb.2022.127055
Reference:
JTEMB127055
To appear in: Journal of Trace Elements in Medicine and Biology
Received date: 29 December 2021
Revised date: 4 July 2022
Accepted date: 2 August 2022
Please cite this article as: Tamer Bego, Neven Meseldžić, Besim Prnjavorac,
Lejla Prnjavorac, Damir Marjanović, Rui Azevedo, Edgar Pinto, Mary Duro,
Cristina Couto and Agostinho Almeida, Association of Trace Element Status in
COVID-19 Patients with Disease Severity, Journal of Trace Elements in
Medicine and Biology, (2021) doi:https://doi.org/10.1016/j.jtemb.2022.127055
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© 2021 Published by Elsevier.
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Association of Trace Element Status in COVID-19 Patients with Disease Severity
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Tamer Bego1*, Neven Meseldžić1, Besim Prnjavorac6,7, Lejla Prnjavorac7, Damir Marjanović8, Rui Azevedo2,
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Edgar Pinto2,3, Mary Duro2,5, Cristina Couto2,4 and Agostinho Almeida2*
Affiliations of the authors:
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Diagnostics, 71000 Sarajevo, Bosnia and Herzegovina
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University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry and Laboratory
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LAQV/REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313
Porto, Portugal
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Department of Environmental Health, School of Health, P.Porto, 4200-072 Porto, Portugal
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TOXRUN – Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra,
of
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3
Portugal
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Fernando Pessoa Health School, 4249-004 Porto, Portugal
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University of Sarajevo, Faculty of Pharmacy, 71000 Sarajevo, Bosnia and Herzegovina
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General Hospital Tešanj, 74260 Tešanj, Bosnia and Herzegovina
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International Burch University, 71000 Sarajevo, Bosnia and Herzegovina
-p
ro
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16 * Corresponding author: Prof. Dr. Tamer Bego, University of Sarajevo, Faculty of Pharmacy, Department of
Pharmaceutical Biochemistry and Laboratory Diagnostics, 71000 Sarajevo, Bosnia and Herzegovina, e-mail
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address: tamer.bego@ffsa.unsa.ba; +387 33 586 188
re
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lP
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Abstract
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Caused by the new SARS-CoV-2 coronavirus, COVID-19 (coronavirus disease 2019) evolves with clinical
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symptoms that vary widely in severity, from mild symptoms to critical conditions, which can even result in the
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patient's death. A critical aspect related to an individual response to SARS-CoV-2 infection is the competence of
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the immune system, and it is well known that several trace elements are essential for an adequate immune re-
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sponse and have anti-inflammatory and antioxidant properties that are of particular importance in fighting infec-
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tion. Thus, it..
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