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Computational characterization of inhaled droplet transport to the nasopharynx

Basu, S., Scientific Reports, doi:10.1038/s41598-021-85765-7
Mar 2021  
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Computational fluid dynamics study tracking inhaled droplet transport in CT-based anatomic reconstructions, showing droplets sized 2.5-19 µm deposit at the highest rates in the nasopharynx, the primary initial infection site for SARS-CoV-2. The number of virions deposited during a 5 minute exposure to an infected individual is estimated to be on the order of hundreds, providing a preliminary estimate of the SARS-CoV-2 infectious dose.
Basu et al., 23 Mar 2021, retrospective, USA, peer-reviewed, 1 author. Contact: saikat.basu@sdstate.edu.
This PaperMiscellaneousAll
Computational characterization of inhaled droplet transport to the nasopharynx
Saikat Basu
Scientific Reports, doi:10.1038/s41598-021-85765-7
How human respiratory physiology and the transport phenomena associated with inhaled airflow in the upper airway proceed to impact transmission of SARS-CoV-2, leading to the initial infection, stays an open question. An answer can help determine the susceptibility of an individual on exposure to a COVID-2019 carrier and can also provide a preliminary projection of the still-unknown infectious dose for the disease. Computational fluid mechanics enabled tracking of respiratory transport in medical imaging-based anatomic domains shows that the regional deposition of virus-laden inhaled droplets at the initial nasopharyngeal infection site peaks for the droplet size range of approximately 2.5-19 µ . Through integrating the numerical findings on inhaled transmission with sputum assessment data from hospitalized COVID-19 patients and earlier measurements of ejecta size distribution generated during regular speech, this study further reveals that the number of virions that may go on to establish the SARS-CoV-2 infection in a subject could merely be in the order of hundreds.
Competing interests The author declares no competing interests.
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Link to Google Drive folder ' '(2021).'}], 'container-title': 'Scientific Reports', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.nature.com/articles/s41598-021-85765-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-021-85765-7', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-021-85765-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 1, 30]], 'date-time': '2023-01-30T03:05:37Z', 'timestamp': 1675047937000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41598-021-85765-7'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 3, 23]]}, 'references-count': 85, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2021, 12]]}}, 'alternative-id': ['85765'], 'URL': 'http://dx.doi.org/10.1038/s41598-021-85765-7', 'relation': {}, 'ISSN': ['2045-2322'], 'subject': [], 'container-title-short': 'Sci Rep', 'published': {'date-parts': [[2021, 3, 23]]}, 'assertion': [ { 'value': '2 October 2020', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '5 March 2021', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '23 March 2021', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'The author declares no competing interests.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '6652'}
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