Supplement Usage Pattern in a Group of COVID-19 Patients in Tehran
Bagheri et al.
, Supplement Usage Pattern in a Group of COVID-19 Patients in Tehran
, Journal of Family & Reproductive Health, doi:10.18502/jfrh.v14i3.4668
Retrospective 510 patients in Iran, showing lower risk of severity with vitamin D (statistically significant) and zinc (not statistically significant) supplementation. IR.TUMS.VCR.REC.1398.1063.
risk of severe case, 60.4% lower, OR 0.40, p = 0.41, treatment 33, control 477, adjusted per study, multinomial logistic regression, RR approximated with OR.
risk of hospitalization, 41.0% lower, RR 0.59, p = 0.37, treatment 4 of 33 (12.1%), control 167 of 477 (35.0%), NNT 4.4, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, binary logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bagheri et al., 1 Sep 2021, retrospective, Iran, peer-reviewed, 6 authors.
Abstract: Original Article
Supplement Usage Pattern in a Group of COVID- 19
Patients in Tehran
Maryam Bagheri; Ph.D.1, Fedyeh Haghollahi; M.Sc.2, Mamak Shariat; M.D.3, Mina Jafarabadi; M.D.2,
Parastoo Aryamloo; M.Sc.4, Elahe Rezayof; B.Sc.2
1 Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Tehran University
of Medical Sciences, Tehran, Iran
2 Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Maternal, Fetal & Neonatal Research Center, Family Health Institute, Tehran University of Medical
Sciences, Tehran, Iran
4 Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Received August 2020; Revised and accepted September 2020
Objective: The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral
infection, causes severe acute respiratory syndrome and was spread throughout the world in early 2020.
The effects of vitamin and micronutrient supplements on the prevention and treatment of COVID- 19
seems challenging in scientific considerations. On the other side generally, experts warn against overconsumption of these supplements.
Materials and methods: This study aimed to investigate the vitamin and micronutrient supplementation
usage pattern in past history of patients with COVID-19 via a cross-sectional inquiry. Totally 510 patients
referring to the infectious disease clinic of Imam Khomeini Hospital in Tehran from March 2020 to May
2020 were recruited. The inclusion criterion was suspected patients for COVID-19 based on clinical
findings and CT scans of the lung. The infected patients included both inpatients (171) and outpatients
(339). Demographic information, clinical signs, and the supplement pattern use were collected through
a questionnaire and the data were statistically analyzed.
Results: Vitamin D3 intake was reported in 30% (103 patients) of outpatients and 16.5% (28 patients) of
hospitalized patients, which is statistically significant (P=0.001). It shows that, the frequency of vitamin D3
consumption in the outpatient group was higher than inpatient group. This significant difference has also
been shown in zinc consumption, in 29 patients (9%) outpatients versus 4 patients (2%) inpatients were
reported (P=0.007). Multi nominal regression showed that vitamin D3 intake has a supportive effect and
reduces the risk of exacerbation and worsening of the disease. (OR=0.291; 95% CI 0.102-.0834, P=0.022).
Conclusion: According to the results of the present study and the findings of other studies, considering
the supportive effect of vitamin D3 in reducing the severity of infectious diseases; Clinical trials with an
appropriate sample size are recommended to investigate the functional role of this vitamin in improving
viral diseases of the respiratory tract.
Keywords: Supplement; COVID-19; Vitamins; Micronutrients
Copyright © 2020 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/).
Noncommercial uses of the work are permitted, provided the original work is properly cited.
Vol. 14, No. 3, September 2020
Journal of Family and Reproductive Health
Ahangarpour et al.
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