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0 0.5 1 1.5 2+ Severe case 60% Improvement Relative Risk Hospitalization 41% Zinc for COVID-19  Bagheri et al.  Prophylaxis Is prophylaxis with zinc beneficial for COVID-19? Retrospective 510 patients in Iran Lower severe cases (p=0.41) and hospitalization (p=0.37), not sig. Bagheri et al., J. Family & Reproducti.., Sep 2021 Favors zinc Favors control

Supplement Usage Pattern in a Group of COVID-19 Patients in Tehran

Bagheri et al., Journal of Family & Reproductive Health, doi:10.18502/jfrh.v14i3.4668
Sep 2021  
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Retrospective 510 patients in Iran, showing lower risk of severity with vitamin D (statistically significant) and zinc (not statistically significant) supplementation. IR.TUMS.VCR.REC.1398.1063.
This study includes zinc and vitamin D.
risk of severe case, 60.4% lower, OR 0.40, p = 0.41, treatment 33, control 477, adjusted per study, multinomial logistic regression, RR approximated with OR.
risk of hospitalization, 41.0% lower, RR 0.59, p = 0.37, treatment 4 of 33 (12.1%), control 167 of 477 (35.0%), NNT 4.4, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, binary logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bagheri et al., 1 Sep 2021, retrospective, Iran, peer-reviewed, 6 authors.
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Supplement Usage Pattern in a Group of COVID-19 Patients in Tehran
Ph.D Maryam Bagheri, M.Sc Fedyeh Haghollahi, Mamak Shariat, Mina Jafarabadi, M.Sc Parastoo Aryamloo
Objective: The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection, causes severe acute respiratory syndrome and was spread throughout the world in early 2020. The effects of vitamin and micronutrient supplements on the prevention and treatment of COVID-19 seems challenging in scientific considerations. On the other side generally, experts warn against overconsumption of these supplements. Materials and methods: This study aimed to investigate the vitamin and micronutrient supplementation usage pattern in past history of patients with COVID-19 via a cross-sectional inquiry. Totally 510 patients referring to the infectious disease clinic of Imam Khomeini Hospital in Tehran from March 2020 to May 2020 were recruited. The inclusion criterion was suspected patients for COVID-19 based on clinical findings and CT scans of the lung. The infected patients included both inpatients (171) and outpatients (339). Demographic information, clinical signs, and the supplement pattern use were collected through a questionnaire and the data were statistically analyzed. Results: Vitamin D3 intake was reported in 30% (103 patients) of outpatients and 16.5% (28 patients) of hospitalized patients, which is statistically significant (P=0.001). It shows that, the frequency of vitamin D3 consumption in the outpatient group was higher than inpatient group. This significant difference has also been shown in zinc consumption, in 29 patients (9%) outpatients versus 4 patients (2%) inpatients were reported (P=0.007). Multi nominal regression showed that vitamin D3 intake has a supportive effect and reduces the risk of exacerbation and worsening of the disease. (OR=0.291; 95% CI 0.102-.0834, P=0.022). Conclusion: According to the results of the present study and the findings of other studies, considering the supportive effect of vitamin D3 in reducing the severity of infectious diseases; Clinical trials with an appropriate sample size are recommended to investigate the functional role of this vitamin in improving viral diseases of the respiratory tract.
Annweiler, COVID-19 and Vitamin D Supplementation: a Multicenter Randomized Controlled Trial of High Dose Versus Standard Dose Vitamin D3 in High-risk COVID-19 Patients
Bagheri, Haghollahi, Shariat, Jafarabadi, Aryamloo et al., Supplement Usage Pattern in a Group of COVID-19 Patients in Tehran, J Fam Reprod Health
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