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0 0.5 1 1.5 2+ Ventilation 97% Improvement Relative Risk Hospitalization 99% Severe case 100% Selenium for COVID-19  Asimi et al.  EARLY TREATMENT Is early treatment with selenium + vitamin D and zinc beneficial for COVID-19? Retrospective 356 patients in Bosnia and Herzegovina Lower ventilation (p<0.0001) and hospitalization (p<0.0001) Asimi et al., Endocrine Abstracts, May 2021 Favors selenium Favors control

Selenium, zinc, and vitamin D supplementation affect the clinical course of COVID-19 infection in Hashimoto’s thyroiditis

Asimi et al., Endocrine Abstracts, doi:10.1530/endoabs.73.PEP14.2
May 2021  
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Retrospective 356 Hashimoto's thyroiditis outpatients, 270 taking vitamin D, zinc, and selenium, showing significantly lower hospitalization with treatment. Authors adjust for age, gender, BMI, and smoking status, reporting statistically significant associations with p<0.001 for hospitalization and mechanical ventilation, however they do not report the adjusted risks.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen; excessive unadjusted differences between groups.
This study includes selenium, zinc, and vitamin D.
risk of mechanical ventilation, 97.4% lower, RR 0.03, p < 0.001, treatment 0 of 270 (0.0%), control 9 of 86 (10.5%), NNT 9.6, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
risk of hospitalization, 99.0% lower, RR 0.010, p < 0.001, treatment 0 of 270 (0.0%), control 24 of 86 (27.9%), NNT 3.6, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
risk of severe case, 99.5% lower, RR 0.005, p < 0.001, treatment 0 of 270 (0.0%), control 51 of 86 (59.3%), NNT 1.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Asimi et al., 22 May 2021, retrospective, Bosnia and Herzegovina, preprint, 3 authors, this trial uses multiple treatments in the treatment arm (combined with vitamin D and zinc) - results of individual treatments may vary.
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Abstract: See discussions, stats, and author profiles for this publication at: Selenium, zinc, and vitamin D supplementation affect the clinical course of COVID-19 infection in Hashimoto s thyroiditis Article in Endocrine Abstracts · May 2021 DOI: 10.1530/endoabs.73.PEP14.2 CITATION READS 1 650 3 authors: Zelija Velija Asimi Almira Hadžović-Džuvo Sarajevo School of Science and Technology, Medical school University of Sarajevo 53 PUBLICATIONS 342 CITATIONS 70 PUBLICATIONS 341 CITATIONS SEE PROFILE SEE PROFILE Djinan Al-Tawil Policlic and daily hospital dr.Al-Tawil 3 PUBLICATIONS 2 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: PUBLIC HEALTH IN THE WESTERN BALKANS – IMPROVEMENT IN THE FIELD OF PUBLIC HEALTH AND DEVELOPMENT OF A “ONE HEALTH” EDUCATIONAL AND SCIENTIFIC ARCHITECTURE IN WESTERN BALKAN COUNTRIES (project ID: EACEA-544182: 544182-TEMPUS-1-2013-1-IT-TEMPUS-JPCR) View project Genetic factors of thromborhilia in pregnancy loss, Crohn disease View project All content following this page was uploaded by Zelija Velija Asimi on 23 May 2021. The user has requested enhancement of the PEP14.2 Selenium, zinc, and vitamin D supplementation affect the clinical course of COVID-19 infection in Hashimoto's thyroiditis Zelija Velija Asimi1,2, Almira Hadzovic-Dzuvo1,3, Djinan Al-Tawil1 1Outpatient Clinic with a Daily hospital "Dr Al Tawil", Sarajevo, 2Sarajevo Medical School, SSST University, 3Sarajevo University, Bosnia and Herzegovina Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Low levels of micronutrients are associated with adverse clinical outcomes during viral infections. Vitamin D improves the physical barrier against the virus and stimulates the production of antimicrobial peptides. It can prevent cytokine storms by reducing the production of inflammatory cytokines. Selenium enhances the function of cytotoxic effector cells. Furthermore, selenium is important for maintaining T cell maturation and function, as well as for producing T cell-dependent antibodies. Our goal was to determine the effects of selenium, zinc, and vitamin D supplementation on recovery from COVID-19 in patients with pre-existing Hashimoto’s thyroiditis. CONCLUSION For the treatment of people with Hashimoto’s thyroiditis who become infected with COVID-19, the addition of selenium, zinc, and vitamin D3 could be beneficial. Randomized controlled trials and large population studies should be performed to evaluate these recommendations. Reference: 1. Alexander J, Tinkov A, Strand TA, Alehagen U, Skalny A, Aaseth J. Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. Nutrients. 2020 Aug 7;12(8):2358. doi: 10.3390/nu12082358. PMID: 32784601; PMCID: PMC7468884. 2. Bae M, Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19. Molecules. 2020 Nov 16;25(22):5346. doi: 10.3390/molecules25225346 3. Im JH, Je YS, Baek J, Chung MH, Kwon HY, Lee JS. Nutritional status of patients with COVID-19. Int J Infect Dis. 2020 Nov;100:390-393. doi: 10.1016/j.ijid.2020.08.018. Epub 2020 Aug 11. 4. Heller RA, Sun Q, Hackler J, Seelig J, Seibert L, Cherkezov A, Minich WB, Seemann P, Diegmann J, Pilz M, Bachmann M, Ranjbar A,..
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