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0 0.5 1 1.5 2+ Case, Jan-Mar 2021 93% Improvement Relative Risk Case, May-Dec 2020 98% Hydrogen Peroxide  Amoah et al.  Prophylaxis Does hydrogen peroxide reduce COVID-19 infections? Retrospective 466 patients in Ghana (May 2020 - December 2021) Fewer cases with hydrogen peroxide (not stat. sig., p=0.22) Amoah et al., J. Hospital Infection, Aug 2022 Favors hydrogen peroxide Favors control

Further observations on hydrogen peroxide antisepsis and COVID-19 cases among healthcare workers and inpatients

Amoah et al., Journal of Hospital Infection, doi:10.1016/j.jhin.2022.05.007
Aug 2022  
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Retrospective 458 healthcare workers in Ghana, showing lower COVID-19 cases with hydrogen peroxide prophylaxis (oral and nasal rinse), without statistical significance.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
risk of case, 92.6% lower, RR 0.07, p = 0.22, treatment 0 of 94 (0.0%), control 10 of 372 (2.7%), NNT 37, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), Jan - Mar 2021.
risk of case, 98.4% lower, RR 0.02, p = 0.61, treatment 0 of 8 (0.0%), control 62 of 396 (15.7%), NNT 6.4, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), May - Dec 2020.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Amoah et al., 31 Aug 2022, retrospective, Ghana, peer-reviewed, 12 authors, study period May 2020 - December 2021.
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Further observations on hydrogen peroxide antisepsis and COVID-19 cases among healthcare workers and inpatients
A G B Amoah, K W Sagoe, I A Quakyi, H N G Ayettey Anie, M N B Ayettey-Adamafio, R N A Ayettey Brew, M Newman-Nartey, N O Nartey, K T C Brightson, G Kessie, A S Ayettey, F I D Konotey-Ahulu
Journal of Hospital Infection, doi:10.1016/j.jhin.2022.05.007
Background: The use of prophylactic antisepsis to protect against coronavirus disease 2019 (COVID-19) has been suggested. This study investigated hydrogen peroxide antisepsis (HPA) at two hospitals in Ghana. Methods: Cases of COVID-19 among healthcare workers (HCWs) using hydrogen peroxide (HP-HCWs) or not using hydrogen peroxide (NHP-HCWs), vaccinated or unvaccinated, were recorded at Shai-Osudoku Hospital (SODH), Dodowa, and Mount Olives Hospital (MOH), Techiman, between May 2020 and December 2021. The effect of HPA in all inpatients at MOH was also observed. Permutation tests were used to determine P values. Findings: At SODH, there were 62 (13.5%) cases of COVID-19 among 458 NHP-HCWs but no cases among eight HP-HCWs (P¼0.622) from May to December 2020. Between January and
Conflict of interest statement None declared.
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