Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Vitamin A  COVID-19 treatment studies for Vitamin A  C19 studies: Vitamin A  Vitamin A   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Progression 67% Improvement Relative Risk Recovery time 38% no CI Al-Sumiadai et al. Vitamin A for COVID-19 EARLY Is early treatment with vitamin A beneficial for COVID-19? Prospective study of 100 patients in Iraq Lower progression with vitamin A (not stat. sig., p=0.27) Al-Sumiadai, Systematic Reviews in Pharmacy, 12:1 Favors vitamin A Favors control
Therapeutic effect of vitamin A on COVID-19 patients and its prophylactic effect on contacts
Al-Sumiadai, Systematic Reviews in Pharmacy, 12:1 (Preprint)
Al-Sumiadai, Therapeutic effect of vitamin A on COVID-19 patients and its prophylactic effect on contacts, , Systematic Reviews in Pharmacy, 12:1 (Preprint)
Jan 2021   Source   PDF  
  All Studies   Meta
Treatment and prophylaxis studies of vitamin A in Iraq.
The treatment study contained 100 patients, 50 treated with 200,000IU vitamin A for two days, showing lower progression to severe disease, and shorter duration of symptoms.
The prophylaxis study contained 209 contacts of COVID-19 patients, 97 treated with vitamin A, showing significantly lower cases with treatment, and shorter duration of symptoms.
risk of progression, 66.7% lower, RR 0.33, p = 0.27, treatment 2 of 50 (4.0%), control 6 of 50 (12.0%), NNT 13, progression to severe disease.
recovery time, 37.5% lower, relative time 0.62, treatment 50, control 50.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Sumiadai et al., 31 Jan 2021, prospective, Iraq, preprint, 3 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperVitamin AAll
Mahmood M Al-Sumiadai, Hazim Ghazzay, Rafi Khaleel Al-Ani
Background: No other similar study was done on the role of vitamin A in the treatment of COVID-19. Objective: To find the effect of vitamin A on patients with COVID-19 and its protective effect on contacts. Patient and Methods: A cross-sectional study was done on two groups. The first group of 100 diagnosed mild to moderate patients with COVID-19, 50 patients received two doses of vitamin A (200,000 I.U.) for two days, another 50 patients received a placebo. Data about clinical features, SPO2, and the mean duration of symptoms collected after 24 and 48 hours from the administration, in addition to the number of patients who deteriorate their SPO2. A second group was contacted to patients diagnosed with COVID-19, part of them received two doses (200,000 I.U.) of vitamin A and others received a placebo. The comparison was between the percentage of getting the infection and the duration of symptoms among those who got the infection. Results: A significant improvement in symptoms, shorter duration of illness, with a lower number of patients who deteriorate their SPO2 among patients given vitamin A compared to control. A lower incidence of infection among contacts who received vitamin A in comparison to contacts received placebo with shorter duration of symptoms among those who got the infection. Conclusions; A great benefit of the use of vitamin A in patients with COVID-19 and to contacts. Adding vitamin, A to the protocol management of COVID-19 is recommended.
Alabama, Franke, Huang, Galea, Calderon et al., Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression, Clin. Infect. Dis
Chen, Yang, Yan, Chen, Yu et al., Influence of vitamin A status on the antiviral immunity of children with hand, foot, and mouth disease, Clin. Nutr
Chen, Yang, Yan, Chen, Yu et al., Influence of vitamin A status on the antiviral immunity of children with hand, foot, and mouth disease, Clin. Nutr
Ghodratizadeh, Kanbak, Beyramzadeh, Dikmen, Memarzadeh et al., Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in a rabbit, Vet. Res. Commun
Heine, Hollstein, Treptow, Radbruch, Worm, 9-cis retinoic acid modulates the type I allergic immune response, J. Allergy. Clin. Immunol
Huang, Liu, Qi, Brand, Zheng, Role of Vitamin A in the Immune System, J Clin Med
Huang, Liu, Role of Vitamin A in the Immune System
Huang, Role of vitamin A in the immune system, J Clin Med
Kang, Park, Cho, Ulrich, Kim, Complementary roles of retinoic acid and TGF-β1 in the coordinated expression of mucosal integrins by T cells, Mucosal. Immunol
Kiss, Rühl, Szegezdi, Fritzsche, Toth et al., Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development, Eur. J. Immunol
Kuwata, Wang, Tamura, Ponnamperuma, Levine et al., Vitamin A deficiency in mice causes a systemic expansion of myeloid cells, Blood
Makinde, Rotimi, Ikumawoyi, Adeyemo, Olayemi, Effect of vitamin A and vitamin C supplementation on oxidative stress in HIV and HIV-TB co-infection at Lagos University Teaching Hospital (LUTH) Nigeria, Afr. Health Sci
Mccullough, Northropclewes, Thurnham, The effect of vitamin A on epithelial integrity, Proc. Nutr. Soc
Michael, Dibley, Jeacocke, Safety and toxicity of vitamin A supplements in pregnancy, Food and Nutrition Bulletin
Nan, Qu-Bei, Zou, Effect of vitamin A as an adjuvant therapy for pneumonia in children: A metaanalysis, Chin. J. Contemp. Pediatr
Ohoka, Yokota, Takeuchi, Maeda, Iwata, Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex, J. Immunol
Olson, Vitamin A
Pantazi, Marks, Stolarczyk, Lycke, Noelle et al., Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition, J. Immunol, doi:10.4049/jimmunol.1500989
Qrafli, El Kari, Aguenaou, Bourkadi, Sadki et al., Low plasma vitamin A concentration is associated with tuberculosis in Moroccan population: A preliminary case-control study, BMC Res. Notes
Ribery, Tanumihardjo, Oral doses of α-retinyl ester track chylomicron uptake and distribution of vitamin A in a male piglet model for newborn infants, J. Nutr
Ross, Encyclopedia of Dietary Supplements
Ross, Nelson's textbook of pediatrics; 21st ed
Semba, Vitamin A and immunity to viral, bacterial, and protozoan infections, Proc Nutr Soc, doi:10.1017/s0029665199000944
Seo, Lee, Jang, Kang, Yoon et al., Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication, Cell Immunol
Wheelwright, Kim, Inkeles, De Leon, Pellegrini et al., All-trans retinoic acid triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2, J. Immunol
Who, Global prevalence of vitamin A deficiency in populations at risk 1995-2005
Wiysonge, Ndze, Kongnyuy, Shey, Vitamin A supplements for reducing mother-to-child HIV transmission, Cochrane Database Syst. Rev
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop