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Therapeutic effect of vitamin A on COVID-19 patients and its prophylactic effect on contacts

Al-Sumiadai et al., Systematic Reviews in Pharmacy, 12:1
Jan 2021  
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0 0.5 1 1.5 2+ Progression 67% Improvement Relative Risk Recovery time 38% no CI Vitamin A  Al-Sumiadai et al.  EARLY TREATMENT Is early treatment with vitamin A beneficial for COVID-19? Prospective study of 100 patients in Iraq Lower progression with vitamin A (not stat. sig., p=0.27) Al-Sumiadai et al., Systematic Reviews.., Jan 2021 Favors vitamin A Favors control
Vitamin A for COVID-19
41st treatment shown to reduce risk in June 2023
*, now known with p = 0.021 from 14 studies.
Lower risk for recovery and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
Treatment and prophylaxis studies of vitamin A in Iraq.
The treatment study contained 100 patients, 50 treated with 200,000IU vitamin A for two days, showing lower progression to severe disease, and shorter duration of symptoms.
The prophylaxis study contained 209 contacts of COVID-19 patients, 97 treated with vitamin A, showing significantly lower cases with treatment, and shorter duration of symptoms.
risk of progression, 66.7% lower, RR 0.33, p = 0.27, treatment 2 of 50 (4.0%), control 6 of 50 (12.0%), NNT 13, progression to severe disease.
recovery time, 37.5% lower, relative time 0.62, treatment 50, control 50.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Sumiadai et al., 31 Jan 2021, prospective, Iraq, preprint, 3 authors.
This PaperVitamin AAll
Mahmood M Al-Sumiadai, Hazim Ghazzay, Rafi Khaleel Al-Ani
Background: No other similar study was done on the role of vitamin A in the treatment of COVID-19. Objective: To find the effect of vitamin A on patients with COVID-19 and its protective effect on contacts. Patient and Methods: A cross-sectional study was done on two groups. The first group of 100 diagnosed mild to moderate patients with COVID-19, 50 patients received two doses of vitamin A (200,000 I.U.) for two days, another 50 patients received a placebo. Data about clinical features, SPO2, and the mean duration of symptoms collected after 24 and 48 hours from the administration, in addition to the number of patients who deteriorate their SPO2. A second group was contacted to patients diagnosed with COVID-19, part of them received two doses (200,000 I.U.) of vitamin A and others received a placebo. The comparison was between the percentage of getting the infection and the duration of symptoms among those who got the infection. Results: A significant improvement in symptoms, shorter duration of illness, with a lower number of patients who deteriorate their SPO2 among patients given vitamin A compared to control. A lower incidence of infection among contacts who received vitamin A in comparison to contacts received placebo with shorter duration of symptoms among those who got the infection. Conclusions; A great benefit of the use of vitamin A in patients with COVID-19 and to contacts. Adding vitamin, A to the protocol management of COVID-19 is recommended.
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