Preventive Value of Black Seed in People at Risk of Infection with COVID -19
Kadhim Ali, Abbas Al-Haidari, Tunjai Namiq Faiq, Ozdan Akram Ghareeb, Abbas Al Haidari
In early 2020, the world health organization (WHO) declared Covid-19 as a global pandemic. Little is known about the potential protective factors against this viral disease. This study aimed to evaluate the preventive role of black seed (BS) in reducing infection rates with Covid-19 in people involved in the study. It is a descriptive, nonrandomized and open-label study in which (376) participants were divided into two equal groups. The control group (CON) included participants who didn't take the black seeds, while the (BS) group included participants who took black seeds once daily at a 40 mg/kg orally. Knowing that the prophylactic efficacy of the black seed was seen through a smaller percentage of infected people at risk. A significantly lower infection rate was observed among black seed group 68 (36.2%) in comparison with the control group 180 (95.7%). Also, the (BS) group showed reduced incidence of infection at intermediate 12 (17.6 %) and low 0 (0.0 %) levels of exposure to risk factors. Therefore, we can conclude that black seed has the ability to reduce infection rates of covid-19 in people at risk.
References
-Bouchentouf, Missoum, Identification of compounds from Nigella sativa as new potential inhibitors of 2019 novel Coronasvirus (COVID-19), Molecular docking study
-Danzi, Loffi, Galeazzi, Gherbesi, Acute pulmonary embolism and COVID-19 pneumonia: a random association?, European heart journal
-Darakhshan, Pour, Colagar, Sisakhtnezhad, Thymoquinone and its therapeutic potentials, Pharmacological research
-Davoodi, Abedi, Salehifar, Alizadeh-Navaei, Rouhanizadeh et al., Febuxostat therapy in outpatients with suspected COVID-19: A clinical trial, International journal of clinical practice
-Gali-Muhtasib, Roessner, Schneider-Stock, Thymoquinone: a promising anti-cancer drug from natural sources, The international journal of biochemistry & cell biology
-Ghareeb, Pathological Changes in Liver Function Induced by Gold Nanoparticles and Protective Role of Tinospora Cordifolia: In Vivo, Annals of the Romanian Society for Cell Biology
-Gheita, Kenawy, Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study, Phytotherapy research
-Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The lancet
-Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The lancet
-Kooti, Hasanzadeh-Noohi, Sharafi-Ahvazi, Asadi-Samani, Ashtary-Larky, Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa), Chin J Nat Med
-Kulyar, Li, Mehmood, Waqas, Li et al., Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic, Phytomedicine
-Kulyar, Li, Mehmood, Waqas, Li et al., Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic, Phytomedicine
-Kumar, Kubota, Chernov, Kasuya, Potential role of zinc supplementation in prophylaxis and treatment of COVID-19, Medical hypotheses
-Li, Geng, Peng, Meng, Lu, Molecular immune pathogenesis and diagnosis of COVID-19, Journal of pharmaceutical analysis
-Mahdavi, Heshmati, Namazi, Effects of black seeds (Nigella sativa) on male infertility: A systematic review, Journal of Herbal Medicine
-Mansour, Nagi, El-Khatib, Am, Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action, Cell biochemistry and function
-Mollazadeh, Afshari, Hosseinzadeh, Review on the potential therapeutic roles of nigella sativa in the treatment of patients with cancer: Involvement of apoptosis:-black cumin and cancer, J Pharmacopuncture
-Mousavi, Sheikhi, Varkaneh, Zarezadeh, Rahmani et al., Effect of Nigella sativa supplementation on obesity indices: A systematic review and meta-analysis of randomized controlled trials, Complementary therapies in medicine
-Rahman, Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19, Journal of herbal medicine
-Ramadhan, Ghareeb, Clinicohematological Study of Gold Nanoparticles Toxicity and Ameliorative Effect of Allium Sativum, Annals of the Romanian Society for Cell Biology
-Sabzghabaee, Dianatkhah, Sarrafzadegan, Asgary, Ghannadi, Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial, Med Arch
-Shang, Wang, Zhang, Wang, Yan et al., The relationship between diabetes mellitus and COVID-19 prognosis: a retrospective cohort study in Wuhan, China, The American journal of medicine
-Sultan, Sultan, Maded, Sultan, A descriptive study of COVID-19 infection among symptomatic patients in Al-Hawija district-Kirkuk-Iraq, International Journal of Psychosocial Rehabilitation
-Tabata, Imai, Kawano, Ikeda, Kodama et al., Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis, The Lancet Infectious Diseases
-Ulasli, Gurses, Bayraktar, Yumrutas, Oztuzcu et al., The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family, Molecular biology reports
-Zhang, Zhang, Wang, Zhu, Wang et al., Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis, Respiratory research
Cascella, Palma, Barbieri, Bimonte, Amruthraj et al., Role of Nigella sativa and its constituent thymoquinone on chemotherapy-induced nephrotoxicity: evidences from experimental animal studies, Nutrients
Gomathinayagam, Ha, Jayaraman, Song, Isidoro et al., Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets, Journal of Cancer Prevention
Goyal, Prajapati, Gore, Patil, Mahajan et al., Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin, Frontiers in pharmacology
Mashayekhi-Sardoo, Rezaee, Karimi, Nigella sativa (black seed) safety: an overview, Asian Biomedicine
Mashayekhi-Sardoo, Rezaee, Karimi, Nigella sativa (black seed) safety: an overview, Asian Biomedicine
Zhang, Wu, Zhang, Deng, Peng, In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus, Journal of integrative medicine