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0 0.5 1 1.5 2+ Case -12% Improvement Relative Risk Adrean et al. Zinc for COVID-19 Prophylaxis Does zinc reduce COVID-19 infections? Retrospective 8,426 patients in the USA (April 2020 - April 2021) No significant difference in cases Adrean et al., Cureus, doi:10.7759/cureus.30881 Favors zinc Favors control
Does Prophylactic Oral Zinc Reduce the Risk of Contracting COVID-19?
Adrean et al., Cureus, doi:10.7759/cureus.30881
Adrean et al., Does Prophylactic Oral Zinc Reduce the Risk of Contracting COVID-19?, Cureus, doi:10.7759/cureus.30881
Oct 2022   Source   PDF  
  All Studies   Meta
Retrospective 8,426 patients in the USA, showing no significant difference in cases with zinc prophylaxis. Severity results were not reported due to the small number of events.
risk of case, 12.2% higher, RR 1.12, p = 0.58, treatment 30 of 2,111 (1.4%), control 80 of 6,315 (1.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Adrean et al., 30 Oct 2022, retrospective, USA, peer-reviewed, survey, 6 authors, study period 1 April, 2020 - 9 April, 2021.
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This PaperZincAll
Does Prophylactic Oral Zinc Reduce the Risk of Contracting COVID-19?
Sean D Adrean, Kenneth Schmitt, Caleb Ng, Ash Pirouz, Hema L Ramkumar, Scott Grant
Cureus, doi:10.7759/cureus.30881
In this study, we aimed to investigate whether zinc provided in Age-Related Eye Disease Study 2 (AREDS2) vitamins is associated with a decreased risk of contracting coronavirus disease 2019 . Materials and methods We conducted a retrospective observational cohort study involving patients at a retina-only practice who were provided a questionnaire at each visit to assess whether they were symptomatic of or had contracted COVID-19. Those who answered yes to testing positive for COVID-19 were retrospectively analyzed and categorized based on their AREDS2 vitamin use, and a Pearson's chi-squared test was performed. Demographic data and past ocular history were also analyzed. Results A total of 8,426 unique patients, including 2,111 with a diagnosis of age-related macular degeneration (AMD), were seen from April 1, 2020, to April 9, 2021. A total of 110 patients (1.3%) reported contracting COVID-19 and had positive COVID-19 tests. The average age of those who had contracted COVID-19 in this study was 68.3 years; 51.8% were male, 30.1% had AMD, 28.2% had diabetic retinopathy, 24.5% had surgical retinal disease, 11.8% had retinal vascular disease, and 4.5% had other disease states. Of the COVID-19positive patients, 27.3% (30/110) took AREDS2 vitamins, while 72.7% (80/110) patients did not. A chisquared analysis was performed, which was not statistically significant (p=0.667). Conclusions Oral zinc supplementation, in the form of AREDS2 vitamins, is not associated with a protective effect against contracting COVID-19.
Conclusions Oral zinc supplementation has been widely purported to reduce symptomatic viral days. It has also been recommended to be used as a prophylaxis for viral infections. It has been speculated that it may help reduce the chance of contracting COVID-19. Zinc is readily available over the counter and is used in the AREDS supplements for macular degeneration. Elderly patients are at increased risk of complications from COVID-19, and hence if zinc supplementation could reduce the chance of contracting COVID-19, that would be highly beneficial. However, based on our findings, oral zinc supplementation in the form of AREDS2 vitamins is not associated with a protective effect against contracting COVID-19. Appendices
Bernal, Andrews, Gower, Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant, N Engl J Med, doi:10.1056/NEJMoa2108891?utm_medium=email&utm_source=transaction
Chinni, El-Khoury, Perera, Zinc supplementation as an adjunct therapy for COVID-19: challenges and opportunities, Br J Clin Pharmacol, doi:10.1111/bcp.14826?utm_medium=email&utm_source=transaction
Cvijanovich, King, Flori, Gildengorin, Vinks et al., Safety and dose escalation study of intravenous zinc supplementation in pediatric critical illness, JPEN J Parenter Enteral Nutr, doi:10.1177/0148607115572193?utm_medium=email&utm_source=transaction
Feng, Zheng, Yan, COVID-19 and liver dysfunction: current insights and emergent therapeutic strategies, J Clin Transl Hepatol, doi:10.14218/JCTH.2020.00018?utm_medium=email&utm_source=transaction
Fukada, Yamasaki, Nishida, Murakami, Hirano, Zinc homeostasis and signaling in health and diseases: zinc signaling, J Biol Inorg Chem, doi:10.1007/s00775-011-0797-4?utm_medium=email&utm_source=transaction
Gold, Sehayek, Gabrielli, Zhang, Mccusker et al., COVID-19 and comorbidities: a systematic review and meta-analysis, Postgrad Med, doi:10.1080/00325481.2020.1786964?utm_medium=email&utm_source=transaction
Gorusupudi, Nelson, Bernstein, The age-related eye disease 2 study: micronutrients in the treatment of macular degeneration, Adv Nutr, doi:10.3945/an.116.013177?utm_medium=email&utm_source=transaction
Hambidge, Miller, Westcott, Sheng, Krebs, Zinc bioavailability and homeostasis, Am J Clin Nutr, doi:10.3945/ajcn.2010.28674I?utm_medium=email&utm_source=transaction
Horby, Lim, Emberson, Dexamethasone in hospitalized patients with Covid-19, N Engl J Med, doi:10.1056/NEJMoa2021436?utm_medium=email&utm_source=transaction
Hulisz, Efficacy of zinc against common cold viruses: an overview, J Am Pharm Assoc, doi:10.1331/1544-3191.44.5.594.hulisz?utm_medium=email&utm_source=transaction
Hunter, Arentz, Goldenberg, Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials, BMJ Open, doi:10.1136/bmjopen-2020-047474?utm_medium=email&utm_source=transaction
Li, Moore, Vasilieva, Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature, doi:10.1038/nature02145?utm_medium=email&utm_source=transaction
Maares, Haase, A guide to human zinc absorption: general overview and recent advances of in vitro intestinal models, Nutrients, doi:10.3390/nu12030762?utm_medium=email&utm_source=transaction
Maares, Haase, Zinc and immunity: an essential interrelation, Arch Biochem Biophys, doi:10.1016/
Maret, Zinc biochemistry: from a single zinc enzyme to a key element of life, Adv Nutr, doi:10.3945/an.112.003038?utm_medium=email&utm_source=transaction
Mcmahon, Udy, Peleg, Remdesivir for the treatment of COVID-19 -preliminary report, N Engl J Med, doi:10.1056/NEJMoa200776?utm_medium=email&utm_source=transaction
Mcpherson, Keunen, Bird, Chew, Van Kuijk, Investigate oral zinc as a prophylactic treatment for those at risk for COVID-19, Am J Ophthalmol, doi:10.1016/j.ajo.2020.04.028?utm_medium=email&utm_source=transaction
Pal, Squitti, Picozza, Zinc and COVID-19: basis of current clinical trials, Biol Trace Elem Res, doi:10.1007/s12011-020-02437-9?utm_medium=email&utm_source=transaction
Read, Obeid, Ahlenstiel, Ahlenstiel, The role of zinc in antiviral immunity, Adv Nutr, doi:10.1093/advances/nmz013?utm_medium=email&utm_source=transaction
Rubin, Chan-Tack, Farley, Sherwat, FDA approval of remdesivir -a step in the right direction, N Engl J Med, doi:10.1056/NEJMp2032369?utm_medium=email&utm_source=transaction
Sadoff, Gray, Vandebosch, Safety and efficacy of single-dose Ad26.COV2.S vaccine against Covid-19, N Engl J Med, doi:10.1056/NEJMoa2101544?utm_medium=email&utm_source=transaction
Suara, Crowe, Effect of zinc salts on respiratory syncytial virus replication, Antimicrob Agents Chemother, doi:10.1128/AAC.48.3.783-790.2004?utm_medium=email&utm_source=transaction
Thomas, Patel, Bittel, Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial, JAMA Netw Open, doi:10.1001/jamanetworkopen.2021.0369?utm_medium=email&utm_source=transaction
V'kovski, Kratzel, Steiner, Stalder, Thiel, Coronavirus biology and replication: implications for SARS-CoV-2, Nat Rev Microbiol, doi:10.1038/s41579-020-00468-6?utm_medium=email&utm_source=transaction
Velthuis, Van Den Worm, Sims, Baric, Snijder et al., Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS Pathog, doi:10.1371/journal.ppat.1001176?utm_medium=email&utm_source=transaction
Voysey, Clemens, Madhi, Safety and efficacy of the ChAdOx1 nCoV-19 vaccine
Wolff, Nee, Hickey, Marschollek, Risk factors for Covid-19 severity and fatality: a structured literature review, Infection, doi:10.1007/s15010-020-01509-1?utm_medium=email&utm_source=transaction
Yao, Paguio, Dee, The minimal effect of zinc on the survival of hospitalized patients with COVID-19: an observational study, Chest, doi:10.1016/j.chest.2020.06.082?utm_medium=email&utm_source=transaction
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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