Conv. Plasma
Nigella Sativa

All vitamin D studies
Meta analysis
study COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The vitamin D binding protein gene polymorphism association with Covid-19-infected Iraqi patients

Abdulameer et al., Cellular and Molecular Biology, doi:10.14715/cmb/2023.69.5.5
Aug 2023  
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Case control study of 150 COVID-19 patients and 150 healthy controls showing that COVID-19 patients had significantly lower vitamin D levels, and that the DBP gene polymorphism rs12785878 TG genotype was associated with higher risk of COVID-19 infection.
Abdulameer et al., 9 Aug 2023, retrospective, Iraq, peer-reviewed, 4 authors. Contact:
This PaperVitamin DAll
The vitamin D binding protein gene polymorphism association with Covid-19-infected Iraqi patients
Nawres Adnan Abdulameer, Malek Eleroui, Hassan H. Nasser, Ibtissem Ben Amara
Cellular and Molecular Biology, doi:10.14715/cmb/2023.69.5.5
Materials and Methods Samples collection Samples were collected from Al-Diwaniyah Hospital from patients infected with Covid-19. The sample was divided into two parts, a section for DNA extraction to polymorphism and the other section for the purpose of examining the level of vitamin D. Primers ARMS-PCR primers for vitamin D binding protein gene polymorphism (DBP rs12785878 -T/G) were designed in this study using the NCBI-SNP data base and Pri-mer1 ARMS-PCR primers design online. These primers were provided by (Scientific Researcher. Co. Ltd. Iraq) as
Abrishami, Dalili, Mohammadi Torbati, Asgari, Arab-Ahmadi et al., Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: A retrospective study, Eur J Nut, doi:10.1007/s00394-020-02411-0
Adams, Sharma, Gacad, Singer, Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis, J Clin Invest
Al-Horani, Dayyih, Mallah, Hamad, Mima et al., Nationality, Gender, Age, and Body Mass Index Influences on Vitamin D Concentration among Elderly Patients and Young Iraqi and Jordanian in Jordan, Biochem Res Int, doi:10.1155/2016/8920503
Alshahawey, A genetic insight into vitamin D binding protein and COVID-19. Med Hypotheses, doi:10.1016/j.mehy.2021.110531
Apaydin, Polat, Dincer Yazan, Ilgin, Elbasan et al., Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID-19, Clinical Endocrinology, doi:10.1111/cen.14664
Batur, Özaydın, Maviş, Gürsu, Harbige et al., Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population, Metabolites, doi:10.3390/metabo11100696
Bikle, Schwartz, Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne), doi:10.3389/fendo.2019.00317
Cantorna, Ooi, Mcdaniel, Weaver, Murine CD8+ T cells but not macrophages express the vitamin D 1alpha-hydroxylase, J Nutr Biochem
Carpagnano, Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x
Cascella, Rajnik, Cuomo, Features, evaluation and treatment coronavirus (COVID-19), Stat Pearls. Treasure Island
Chen, Eapen, Zosky, Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide, Sci Rep
Faniyi, Lugg, Faustini, Webster, Duffy et al., Vitamin D status and seroconversion for COVID-19 in UK healthcare workers, Eur Respir J, doi:10.1183/13993003.04234-2020
Freitas, Calhau, Antunes, Araújo, Bandeira et al., Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity, Sci Rep, doi:10.1038/s41598-021-99952-z
Ghazy, A genetic insight into vitamin D binding protein and COVID-19, Medical Hypotheses, doi:10.1016/j.mehy.2021.110531
Gombart, Borregaard, Koeffler, Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3, FASEB J, doi:10.1096/fj.04-3284com
Hafez, Saleh, Arya, Alzouhbi, Alla et al., Vitamin D Status in Relation to the Clinical Outcome of Hospitalized CO-VID-19 Patients, Front Med (Lausanne), doi:10.3389/fmed.2022.843737
Hashemi, Thijssen, Hosseini, Tabarraei, Pourkarim et al., Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection, Arch Virol, doi:10.1007/s00705-021-05070-6
Hu, Guo, Zhou, Shi, Characteristics of SARS-CoV-2 and COVID-19, Nat Rev Microbiol, doi:10.1038/s41579-020-00459-7
Mamurova, Akan, Mogol, Turgay, Tuncel et al., Strong Association between Vitamin D Receptor Gene and Severe Acute Respiratory Syndrome coronavirus 2 Infectious Variants, Glob Med Genet, doi:10.1055/s-0043-1761924
Manca, Cosma, Palermiti, Costanzo, Antonucci et al., The Possible Contribution of Vitamin D. Nutrients, doi:10.3390/nu14163275
Nasser-Dhabaan, Alwan, Polymorphisms of IFN-γ T/A +874 Gene and Relationship with COVID 19 in Iraqi Population, IOP Conference Series: Earth and Environmental Science, doi:10.1088/1755-1315/790/1/012049
Newton, Baatz, Kindy, Gattoni-Celli, Shary et al., Vitamin D binding protein polymorphisms significantly impact vitamin D status in children, Pediatr Res, doi:10.1038/s41390-019-0322-y.Epub
Santo, Franchini, Filiputti, Martone, Sannino, The Effects of COVID-19 and Quarantine Measures on the Lifestyles and Mental Health of People Over 60 at Increased Risk of Dementia. Front Psychiatry, doi:10.3389/fpsyt.2020.578628
Speeckaert, Delanghe, Contribution of Vitamin D-Binding Protein Polymorphism to Susceptibility and Outcome of COVID-19 Patients, J Nutr, doi:10.1093/jn/nxab234
Speeckaert, Delanghe, Vitamin D binding protein and its polymorphisms may explain the link between vitamin D deficiency and COVID-19, Sci Prog, doi:10.1177/00368504211053510
Wang, Horby, Hayden, Gao, A novel coronavirus outbreak of global health concern, Lancet, doi:10.1016/S0140-6736(20)30185-9
Zrieq, Snoussi, Algahtan, Tasleem, Saeed et al., Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches, Cell Mol Biol, doi:10.14715/cmb/2021.67.5.51
{ 'indexed': {'date-parts': [[2023, 8, 13]], 'date-time': '2023-08-13T04:16:33Z', 'timestamp': 1691900193887}, 'reference-count': 0, 'publisher': 'CMB Association', 'issue': '5', 'license': [ { 'start': { 'date-parts': [[2023, 5, 31]], 'date-time': '2023-05-31T00:00:00Z', 'timestamp': 1685491200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': ''}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p />', 'DOI': '10.14715/cmb/2023.69.5.5', 'type': 'journal-article', 'created': {'date-parts': [[2023, 8, 12]], 'date-time': '2023-08-12T08:11:40Z', 'timestamp': 1691827900000}, 'page': '26-31', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The vitamin D binding protein gene polymorphism association with Covid-19-infected Iraqi ' 'patients', 'prefix': '10.14715', 'volume': '69', 'author': [ {'family': 'Nawres Adnan Abdulameer', 'sequence': 'first', 'affiliation': []}, {'family': 'Malek Eleroui', 'sequence': 'additional', 'affiliation': []}, {'family': 'Hassan H. Nasser', 'sequence': 'additional', 'affiliation': []}, {'family': 'Ibtissem Ben Amara', 'sequence': 'additional', 'affiliation': []}], 'member': '5752', 'published-online': {'date-parts': [[2023, 5, 31]]}, 'container-title': 'Cellular and Molecular Biology', 'original-title': [], 'link': [ { 'URL': '', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 8, 12]], 'date-time': '2023-08-12T08:13:23Z', 'timestamp': 1691828003000}, 'score': 1, 'resource': {'primary': {'URL': ''}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 5, 31]]}, 'references-count': 0, 'journal-issue': {'issue': '5', 'published-online': {'date-parts': [[2023, 8, 9]]}}, 'URL': '', 'relation': {}, 'ISSN': ['1165-158X', '0145-5680'], 'subject': ['General Medicine'], 'container-title-short': 'Cell Mol Biol (Noisy-le-grand)', 'published': {'date-parts': [[2023, 5, 31]]}}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop