The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis

{ 'indexed': {'date-parts': [[2023, 9, 27]], 'date-time': '2023-09-27T17:40:04Z', 'timestamp': 1695836404151}, 'reference-count': 78, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2023, 9, 26]], 'date-time': '2023-09-26T00:00:00Z', 'timestamp': 1695686400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Coronavirus disease (COVID‐19) affects both the ' 'respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, ' 'as potential treatment methods to help patients combat COVID‐19. The aim of this systematic ' 'review and meta‐analysis is to give a comprehensive overview of the impact of quercetin ' 'supplementation on inflammatory factors, hospital admission, and mortality of patients with ' 'COVID‐19. The search has been conducted on PubMed, Scopus, Web of Science, EMBASE, and the ' 'Cochrane Library using relevant keywords until August 25, 2023. We included randomized ' 'controlled trials (RCTs) comparing COVID‐19 patients who received quercetin supplementation ' 'versus controls. We included five studies summarizing the evidence in 544 patients. ' 'Meta‐analysis showed that quercetin administration significantly reduced LDH activity ' '(standard mean difference (SMD): −0.42, 95% CI: −0.82, −0.02, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\u2009=\u200948.86%), decreased the risk of ' 'hospital admission by 70% (RR: 0.30, 95% CI: 0.14, 0.62, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\u2009=\u200900.00%), ICU admission by 73% ' '(RR: 0.27, 95% CI: 0.09, 0.78, <jats:italic>I</jats:italic><jats:sup>2</jats:sup>\u2009=\u2009' '20.66%), and mortality by 82% (RR: 0.18, 95% CI: 0.03, 0.98, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\u2009=\u200900.00%). No significant ' 'changes in CRP, D‐dimmer, and ferritin were found between groups. Quercetin was found to ' 'significantly reduce LDH levels and decrease the risk of hospital and ICU admission and ' 'mortality in patients with COVID‐19 infection.</jats:p>', 'DOI': '10.1002/fsn3.3715', 'type': 'journal-article', 'created': {'date-parts': [[2023, 9, 26]], 'date-time': '2023-09-26T07:48:38Z', 'timestamp': 1695714518000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The effect of quercetin supplementation on clinical outcomes in <scp>COVID</scp>‐19 patients: A ' 'systematic review and meta‐analysis', 'prefix': '10.1002', 'author': [ { 'given': 'Somayeh', 'family': 'Ziaei', 'sequence': 'first', 'affiliation': [ { 'name': 'ICU Department, Emam Reza Hospital Kermanshah University of ' 'Medical Sciences Kermanshah Iran'}]}, { 'given': 'Malek', 'family': 'Alimohammadi‐Kamalabadi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Cellular‐Molecular Nutrition, School of ' 'Nutritional Sciences and Dietetics Tehran University of Medical ' 'Sciences Tehran Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-9002-1192', 'authenticated-orcid': False, 'given': 'Motahareh', 'family': 'Hasani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Nutritional Sciences, School of Health Golestan ' 'University of Medical Sciences Gorgan Iran'}]}, { 'given': 'Mahsa', 'family': 'Malekahmadi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Cellular‐Molecular Nutrition, School of ' 'Nutritional Sciences and Dietetics Tehran University of Medical ' 'Sciences Tehran Iran'}, { 'name': 'Imam Khomeini Hospital Complex, Tehran University of Medicinal ' 'Sciences Tehran Iran Tehran University of Medical Sciences ' 'Tehran Iran'}]}, { 'given': 'Emma', 'family': 'Persad', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department for Evidence‐based Medicine and Evaluation Danube ' 'University Krems Krems Austria'}]}, { 'ORCID': 'http://orcid.org/0000-0002-2676-0185', 'authenticated-orcid': False, 'given': 'Javad', 'family': 'Heshmati', 'sequence': 'additional', 'affiliation': [ { 'name': 'Songhor Healthcare Center Kermanshah University of Medical ' 'Sciences Kermanshah Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 9, 26]]}, 'reference': [ { 'key': 'e_1_2_12_2_1', 'doi-asserted-by': 'crossref', 'first-page': '1693', 'DOI': '10.1016/j.ijbiomac.2020.07.235', 'article-title': 'Structural stability of SARS‐CoV‐2 3CLpro and identification of ' 'quercetin as an inhibitor by experimental screening', 'volume': '164', 'author': 'Abian O.', 'year': '2020', 'journal-title': 'International Journal of Biological Macromolecules'}, { 'issue': '5626', 'key': 'e_1_2_12_3_1', 'doi-asserted-by': 'crossref', 'first-page': '1763', 'DOI': '10.1126/science.1085658', 'article-title': 'Coronavirus main proteinase (3CLpro) structure: Basis for design of ' 'anti‐SARS drugs', 'volume': '300', 'author': 'Anand K.', 'year': '2003', 'journal-title': 'Science'}, { 'issue': '1', 'key': 'e_1_2_12_4_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s13017-021-00354-3', 'article-title': 'Serum ferritin levels in inflammation: A retrospective comparative ' 'analysis between COVID‐19 and emergency surgical non‐COVID‐19 patients', 'volume': '16', 'author': 'Banchini F.', 'year': '2021', 'journal-title': 'World Journal of Emergency Surgery'}, { 'issue': '1', 'key': 'e_1_2_12_5_1', 'doi-asserted-by': 'crossref', 'first-page': '37', 'DOI': '10.1016/j.medcli.2020.07.043', 'article-title': 'Lactate dehydrogenase, COVID‐19 and mortality', 'volume': '156', 'author': 'Bartziokas K.', 'year': '2021', 'journal-title': 'Medicina Clínica'}, { 'issue': '3', 'key': 'e_1_2_12_6_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.heliyon.2021.e06515', 'article-title': 'Evaluation of flavonoids as 2019‐nCoV cell entry inhibitor through ' 'molecular docking and pharmacological analysis', 'volume': '7', 'author': 'Bhowmik D.', 'year': '2021', 'journal-title': 'Heliyon'}, { 'key': 'e_1_2_12_7_1', 'first-page': '1', 'article-title': 'Antiviral effects of quercetin and related compounds', 'volume': '2020', 'author': 'Chaabi M.', 'year': '2020', 'journal-title': 'Naturopathic Currents'}, { 'key': 'e_1_2_12_8_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/rmv.2427', 'article-title': 'Quercetin for the treatment of COVID‐19 patients: A systematic review ' 'and meta‐analysis', 'volume': '33', 'author': 'Cheema H. 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