Systematic review and network meta-analysis of 160 studies involving over 900,000 COVID-19 patients assessing the efficacy and safety of small-molecule antivirals. For VV116, significant benefit was found for viral clearance.
Currently there are 2 deuremidevir studies and meta-analysis shows:
| Outcome | Improvement |
|---|
Zheng et al., 18 Jan 2024, peer-reviewed, 11 authors, trial PROSPERO CRD42023396617.
Contact: 13819462633@163.com, zml9998@sina.com, ligonghua88@163.com.
Small-molecule antivirals treatment for COVID-19: A systematic review and network meta-analysis
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2024.107096
Highlights Systematic review and network meta-analysis assessing the efficacy and safety of small-molecule antivirals treatment for COVID-19. Proxalutamide, nirmatrelvir/ritonavir, triazavirin, azvudine, molnupiravir, and VV116 were ranked as the most effective drugs overall in both mild-to-moderate and unstratified groups. In both mild-to-moderate and unstratified groups, leritrelvir ranked first in virus clearance on days 7; however, no significant statistical difference was observed between leritrelvir and the subsequent medications Simnotrelvir/ritonavir and leritrelvir need further clinical data to confirm their efficacy and safety profiles. In terms of safety, the incidence of serious adverse events did not demonstrate an increase across all small-molecule antivirals, thereby confirming their favorable tolerability.
Competing Interests: The authors declare no competing interests. Ethical Approval: Not required.
Sequence Information: Not applicable
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