Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

DOI record: { "DOI": "10.7554/elife.94973", "ISSN": [ "2050-084X" ], "URL": "http://dx.doi.org/10.7554/elife.94973", "abstract": "<jats:sec id=\"abs1\"><jats:title>Background:</jats:title><jats:p>Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use increases the risks of these respiratory infections.</jats:p></jats:sec><jats:sec id=\"abs2\"><jats:title>Methods:</jats:title><jats:p>The current study included 160,923 eligible participants at baseline who completed questionnaires on medication use, which included PPI or histamine-2 receptor antagonist (H2RA), from the UK Biobank. Cox proportional hazards regression and propensity score-matching analyses were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).</jats:p></jats:sec><jats:sec id=\"abs3\"><jats:title>Results:</jats:title><jats:p>Comparisons with H2RA users were tested. PPI use was associated with increased risks of developing influenza (HR 1.32, 95% CI 1.12–1.56) and pneumonia (hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.26–1.59). In contrast, the risk of COVID-19 infection was not significant with regular PPI use (HR 1.08, 95% CI 0.99–1.17), while the risks of severe COVID-19 (HR 1.19. 95% CI 1.11–1.27) and mortality (HR 1.37. 95% CI 1.29–1.46) were increased. However, when compared with H2RA users, PPI users were associated with a higher risk of influenza (HR 1.74, 95% CI 1.19–2.54), but the risks with pneumonia or COVID-19-related outcomes were not evident.</jats:p></jats:sec><jats:sec id=\"abs4\"><jats:title>Conclusions:</jats:title><jats:p>PPI users are associated with increased risks of influenza, pneumonia, as well as COVID-19 severity and mortality compared to non-users, while the effects on pneumonia or COVID-19-related outcomes under PPI use were attenuated when compared to the use of H2RAs. Appropriate use of PPIs based on comprehensive evaluation is required.</jats:p></jats:sec><jats:sec id=\"abs5\"><jats:title>Funding:</jats:title><jats:p>This work is supported by the National Natural Science Foundation of China (82171698, 82170561, 81300279, 81741067, 82100238), the Program for High-level Foreign Expert Introduction of China (G2022030047L), the Natural Science Foundation for Distinguished Young Scholars of Guangdong Province (2021B1515020003), the Guangdong Basic and Applied Basic Research Foundation (2022A1515012081), the Foreign Distinguished Teacher Program of Guangdong Science and Technology Department (KD0120220129), the Climbing Program of Introduced Talents and High-level Hospital Construction Project of Guangdong Provincial People’s Hospital (DFJH201923, DFJH201803, KJ012019099, KJ012021143, KY012021183), and in part by VA Clinical Merit and ASGE clinical research funds (FWL).</jats:p></jats:sec>", "alternative-id": [ "10.7554/eLife.94973" ], "assertion": [ { 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"1985" }, { "DOI": "10.3389/fphar.2022.791074", "article-title": "The association between proton pump inhibitors and covid-19 is confounded by hyperglycemia in a population-based study", "author": "Shafrir", "doi-asserted-by": "publisher", "journal-title": "Frontiers in Pharmacology", "key": "bib33", "volume": "13", "year": "2022" }, { "DOI": "10.1136/gutjnl-2021-325701", "article-title": "Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort", "author": "Shah", "doi-asserted-by": "publisher", "first-page": "1447", "journal-title": "Gut", "key": "bib34", "volume": "71", "year": "2022" }, { "DOI": "10.1038/s41598-022-11680-0", "article-title": "Proton pump inhibitor therapy usage and associated hospitalization rates and critical care outcomes of COVID-19 patients", "author": "Shupp", "doi-asserted-by": "publisher", "journal-title": "Scientific Reports", "key": "bib35", "volume": "12", "year": "2022" }, { "DOI": "10.18637/jss.v042.i08", "article-title": "MatchIt: nonparametric preprocessing for parametric causal inference", "author": "Stuart", "doi-asserted-by": "publisher", "journal-title": "Journal of Statistical Software", "key": "bib36", "volume": "42", "year": "2011" }, { "DOI": "10.1371/journal.pmed.1001779", "article-title": "UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age", "author": "Sudlow", "doi-asserted-by": "publisher", "journal-title": "PLOS Medicine", "key": "bib37", "volume": "12", "year": "2015" }, { "DOI": "10.1053/j.gastro.2021.12.247", "article-title": "Aga clinical practice update on de-prescribing of proton pump inhibitors: expert review", "author": "Targownik", "doi-asserted-by": "publisher", "first-page": "1334", "journal-title": "Gastroenterology", "key": "bib38", "volume": "162", "year": "2022" }, { "DOI": "10.1053/j.gastro.2017.04.047", "article-title": "Complications of proton pump inhibitor therapy", "author": "Vaezi", "doi-asserted-by": "publisher", "first-page": "35", "journal-title": "Gastroenterology", "key": "bib39", "volume": "153", "year": "2017" }, { "DOI": "10.18637/jss.v045.i03", "article-title": "Multivariate imputation by chained equations in R", "author": "van Buuren", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Journal of Statistical Software", "key": "bib40", "volume": "45", "year": "2011" }, { "DOI": "10.1183/13993003.03229-2020", "article-title": "The risk of community-acquired pneumonia in children using gastric acid suppressants", "author": "van der Sande", "doi-asserted-by": "publisher", "journal-title": "The European Respiratory Journal", "key": "bib41", "volume": "58", "year": "2021" }, { "DOI": "10.7326/M16-2607", "article-title": "Sensitivity analysis in observational research: introducing the e-value", "author": "VanderWeele", "doi-asserted-by": "publisher", "first-page": "268", "journal-title": 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