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Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System

Yeramaneni et al., Gastroenterology, doi:10.1053/j.gastro.2020.10.011
Feb 2021  
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Mortality 7% Improvement Relative Risk Azithromycin  Yeramaneni et al.  LATE TREATMENT Is late treatment with azithromycin beneficial for COVID-19? Retrospective 7,158 patients in the USA (February - May 2020) No significant difference in mortality c19early.org Yeramaneni et al., Gastroenterology, Feb 2021 Favorsazithromycin Favorscontrol 0 0.5 1 1.5 2+
Retrospective 7,158 hospitalized COVID-19 patients in the USA analyzing famotidine treatment, showing no significant difference in mortality with associated azithromycin treatment.
Standard of Care (SOC): SOC for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
Study covers remdesivir and famotidine.
risk of death, 7.0% lower, OR 0.93, p = 0.84, treatment 4,003, control 3,155, adjusted per study, multivariable, day 30, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yeramaneni et al., 28 Feb 2021, retrospective, USA, peer-reviewed, 6 authors, study period 11 February, 2020 - 8 May, 2020.
This PaperAzithromycinAll
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Late treatment
is less effective
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