Obesity, walking pace and risk of severe COVID-19 and mortality: analysis of UK Biobank
Yates et al.,
Obesity, walking pace and risk of severe COVID-19 and mortality: analysis of UK Biobank,
International Journal of Obesity, doi:10.1038/s41366-021-00771-z
UK Biobank retrospective 412,596 people, showing severe COVID-19 and COVID-19 mortality inversely associated with self-reported walking pace.
risk of death, 45.3% lower, RR 0.55, p = 0.001, high activity levels 72 of 163,912 (0.0%), low activity levels 62 of 30,119 (0.2%), adjusted per study, inverted to make RR<1 favor high activity levels, odds ratio converted to relative risk, multivariable.
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risk of severe case, 46.7% lower, RR 0.53, p < 0.001, high activity levels 291 of 163,912 (0.2%), low activity levels 180 of 30,119 (0.6%), adjusted per study, inverted to make RR<1 favor high activity levels, odds ratio converted to relative risk, multivariable.
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Yates et al., 26 Feb 2021, retrospective, United Kingdom, peer-reviewed, 7 authors.
Abstract: International Journal of Obesity (2021) 45:1155–1159
https://doi.org/10.1038/s41366-021-00771-z
BRIEF COMMUNICATION
Epidemiology and Population Health
Obesity, walking pace and risk of severe COVID-19 and mortality:
analysis of UK Biobank
Thomas Yates 1,2 Cameron Razieh1,2 Francesco Zaccardi1,3 Alex V. Rowlands
Melanie J. Davies1,2,4 Kamlesh Khunti 1,3,4,5
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Samuel Seidu1
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Received: 17 June 2020 / Revised: 11 December 2020 / Accepted: 21 January 2021 / Published online: 26 February 2021
© The Author(s), under exclusive licence to Springer Nature Limited 2021
Abstract
Obesity is an emerging risk factor for coronavirus disease-2019 (COVID-19). Simple measures of physical fitness, such as
self-reported walking pace, may also be important risk markers. This analysis includes 412,596 UK Biobank participants
with linked COVID-19 data (median age at linkage = 68 years, obese = 24%, median number of comorbidities = 1). As of
August 24th 2020, there were 1001 cases of severe (in-hospital) disease and 336 COVID-19 deaths. Compared to normal
weight individuals, the adjusted odds ratio (OR) of severe COVID-19 in overweight and obese individuals was 1.26 (1.07,
1.48) and 1.49 (1.25, 1.79), respectively. For COVID-19 mortality, the ORs were 1.19 (0.88, 161) and 1.82 (1.33, 2.49),
respectively. Compared to those with a brisk walking pace, the OR of severe COVID-19 for steady/average and slow
walkers was 1.13 (0.98, 1.31) and 1.88 (1.53, 2.31), respectively. For COVID-19 mortality, the ORs were 1.44 (1.10, 1.90)
and 1.83 (1.26, 2.65), respectively. Slow walkers had the highest risk regardless of obesity status. For example, compared to
normal weight brisk walkers, the OR of severe disease and COVID-19 mortality in normal weight slow walkers was 2.42
(1.53, 3.84) and 3.75 (1.61, 8.70), respectively. Self-reported slow walkers appear to be a high-risk group for severe COVID19 outcomes independent of obesity.
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