TriNetX PSM retrospective 10,935 COVID-19 patients, showing higher mortality with zinc deficiency.
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risk of death, 70.8% lower, HR 0.29, p = 0.005, high zinc levels (≥70µg/dL) 10 of 1,447 (0.7%), low zinc levels (<70µg/dL) 20 of 1,447 (1.4%), inverted to make HR<1 favor high zinc levels (≥70µg/dL), Kaplan–Meier.
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risk of death/hospitalization, 27.3% lower, HR 0.73, p = 0.03, high zinc levels (≥70µg/dL) 81 of 1,447 (5.6%), low zinc levels (<70µg/dL) 107 of 1,447 (7.4%), NNT 56, inverted to make HR<1 favor high zinc levels (≥70µg/dL), Kaplan–Meier.
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risk of hospitalization, 17.9% lower, HR 0.82, p = 0.21, high zinc levels (≥70µg/dL) 74 of 1,447 (5.1%), low zinc levels (<70µg/dL) 87 of 1,447 (6.0%), NNT 111, inverted to make HR<1 favor high zinc levels (≥70µg/dL), Kaplan–Meier.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Wu et al., 29 Jun 2023, retrospective, multiple countries, peer-reviewed, 9 authors, study period 1 January, 2022 - 30 April, 2023.
Contact:
m880419@mail.chimei.org.tw, nicolar930@gmail.com, rositatsai@gmail.com, andy10271@gmail.com, liu.tingkle@gmail.com, b0807246@gmail.com, 60028a@gmail.com, wayne54019@gmail.com, dtmed141@gmail.com.
The association between zinc deficiency, and clinical outcomes of COVID-19
Jheng-Yan Wu, Wan-Hsuan Hsu, Ya-Wen Tsai, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Szu-En Chin, Chih-Cheng Lai, Mei-Yuan Liu
Journal of Infection, doi:10.1016/j.jinf.2023.06.021
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Declarations of interest All authors declared there was no conflict of interests
Declaration of Competing Interest We have submitted our manuscript entitled, "The association between zinc deficiency, and clinical outcomes of COVID-19", to Journal of Infection for publication. We will not submit this paper to any another journal. All the authors have read the final version of the manuscript and have agreed to its content. All of the authors also declared that there was no conflict of interests.
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