Conv. Plasma
Nigella Sativa

All vitamin D studies
Meta analysis
study COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Low mortality from COVID-19 at a nursing facility in France following a combined preventive and active treatment protocol

Worcel et al., Annals of Palliative Medicine, doi:10.21037/apm-21-1707
Oct 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Report on the relatively low mortality and relatively mild COVID-19 symptoms at a French nursing facility that has adopted several treatments including vitamin D, zinc, anticoagulants, corticosteroids, and a multivitamin.
Study covers vitamin D and zinc.
Worcel et al., 12 Oct 2021, peer-reviewed, 5 authors.
This PaperVitamin DAll
Low mortality from COVID-19 at a nursing facility in France following a combined preventive and active treatment protocol
Alexandre Worcel, Bougacha M Ali, Sonia Ramos-Pascual, Patrick Stirling, François G Chary
Annals of Palliative Medicine, doi:10.21037/apm-21-1707
Background: The aim of this study was to retrospectively describe the evolution of symptoms, infections, and mortality at a nursing facility in France that had implemented a protocol for the prevention and treatment of COVID-19. Methods: A database was created on 21 March 2020 to store all information related to residents, including co-morbidities, as well as COVID-19 symptoms, incidence, and mortality. Residents followed a COVID-19 protocol, consisting of preventive (administering vitamins and zinc, social distancing, and temperature checks) and active (antibiotics, anticoagulants, and corticosteroids) measures. RT-PCR and serology testing were performed on residents. A new coefficient, named the Zemgor coefficient, was calculated as the haemoglobin-to-albumin ratio at 2 time points 15 days apart, to monitor hypoxemia. Results: In January 2020, the nursing facility housed 192 residents, 75 men and 117 women, aged 80±11. One or more co-morbidities were present in 94% of residents, with the most common being dementia. The COVID-19 protocol provided 61% of residents with anticoagulants, 51%with antibiotics, 21% with oxygen therapy, and 3% with corticosteroids. The COVID-19 incidence was 51% based on presence of COVID-19 symptoms, 35% based on positive RT-PCR (amongst residents tested for RT-PCR) and 41% based on positive serology (amongst residents tested for serology), and the COVID-19 mortality rate was 8%. The Zemgor coefficient was 0.049±0.053 for patients with hypoxemia compared to 0.011±0.041 for patients without hypoxemia (P=0.001). Conclusions: The protocol for the prevention and treatment of COVID-19 implemented at this nursing facility resulted in a COVID-19 incidence and mortality at the lower end of that reported by other nursing facilities.
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi. org/10.21037/apm-21-1707). ELSAN provided funding for manuscript preparation. SRP is an employee of ReSurg SA. PS received consultancy fees from ReSurg SA. Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the institutional review board of Groupement de Coopération Sanitaire ELSAN (IRB #2020-11-WORCEL-01). Residents (or their guardians) provided informed consent for their data to be used for research and publication purposes. Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:
Akaike, A new look at the statistical model identification, IEEE Transactions on Automatic Control
Alimohamadi, Taghdir, Sepandi, Estimate of the Basic Reproduction Number for COVID-19: A Systematic Review and Meta-analysis, J Prev Med Public Health
Annweiler, Corvaisier, Gautier, Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study, Nutrients
Annweiler, Hanotte, De L'eprevier, Vitamin D and survival in COVID-19 patients: A quasi-experimental study, J Steroid Biochem Mol Biol
Arons, Hatfield, Reddy, Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility, N Engl J Med
Belmin, Um-Din, Donadio, Coronavirus Disease 2019 Outcomes in French Nursing Homes That Implemented Staff Confinement With Residents, JAMA Netw Open
Bert, Tan, Kunasegaran, SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls, Nature
Blain, Rolland, Tuaillon, Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak, J Am Med Dir Assoc
Borges Do Nascimento, Cacic, Abdulazeem, Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis, J Clin Med
Borras-Bermejo, Martínez-Gómez, Miguel, Asymptomatic SARS-CoV-2 Infection in Nursing Homes, Emerg Infect Dis, doi:10.3201/eid2609.202603
Brown, Jones, Daneman, Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada, JAMA Intern Med
Carrillo-Larco, Fernandez, Anosmia and dysgeusia in COVID-19: A systematic review, Wellcome Open Res
Chen, Lou, Bai, COVID-19 Disease With Positive Fecal and Negative Pharyngeal and Sputum Viral Tests, Am J Gastroenterol
Daneshkhah, Agrawal, Eshein, Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients, Aging Clin Exp Res
Dora, Winnett, Fulcher, Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial Polymerase Chain Reaction Testing, and Cohorting of Positive Severe Acute Respiratory Syndrome Coronavirus 2 Patients in a Skilled Nursing Facility, Clin Infect Dis
Dora, Winnett, Jatt, Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans -Los Angeles, California, 2020, MMWR Morb Mortal Wkly Rep
Díaz, Ramos-Suzarte, Martín, Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19, Gerontology
Escobar, Lanzi, Saberi, Mitigation of a Coronavirus Disease 2019 Outbreak in a Nursing Home Through Serial Testing of Residents and Staff, Clin Infect Dis
Graham, Junghans, Downes, SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes, J Infect
Kamel, Sobhy, Magdy, Anticoagulation outcomes in hospitalized Covid-19 patients: A systematic review and meta-analysis of case-control and cohort studies, Rev Med Virol
Kennelly, Dyer, Noonan, Asymptomatic carriage rates and case fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes, Age Ageing
Kim, An, Kim, Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis, PLoS Med
Kimball, Hatfield, Arons, Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility -King County, Washington, MMWR Morb Mortal Wkly Rep
Klein, Edler, Fitzek, The first COVID-19 hotspot in a retirement home in Hamburg, Rechtsmedizin, doi:10.1007/s00194-020-00404-1
Matsushita, Ding, Kou, The Relationship of COVID-19 Severity with Cardiovascular Disease and Its Traditional Risk Factors: A Systematic Review and Meta-Analysis, Glob Heart
Mcconeghy, White, Panagiotou, Temperature Screening for SARS-CoV-2 in Nursing Homes: Evidence from Two National Cohorts, J Am Geriatr Soc
Mcmichael, Currie, Clark, Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington, N Engl J Med
Montoya, Jenq, Mills, Partnering with Local Hospitals and Public Health to Manage COVID-19 Outbreaks in Nursing Homes, J Am Geriatr Soc
Ni, Ye, Cheng, Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19
Palaiodimos, Chamorro-Pareja, Karamanis, Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients, Hormones
Parohan, Yaghoubi, Seraji, Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies, Aging Male
Pijls, Jolani, Atherley, Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies, BMJ Open
Recalcati, Cutaneous manifestations in COVID-19: a first perspective, J Eur Acad Dermatol Venereol
Roxby, Greninger, Hatfield, Outbreak Investigation of COVID-19 Among Residents and Staff of an Independent and Assisted Living Community for Older Adults in Seattle, Washington, JAMA Intern Med
Sacco, Foucault, Briere, COVID-19 in seniors: Findings and lessons from mass screening in a nursing home, Maturitas
Silverio, Maio, Citro, Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients, BMC Cardiovasc Disord
Song, Kim, Yoo, COVID-19 in Nursing Facilities: Experience in Republic of Korea, Osong Public Health Res Perspect
Thompson, Barbu, Beiu, The Impact of COVID-19 Pandemic on Long-Term Care Facilities Worldwide: An Overview on International Issues, Biomed Res Int
Vabret, Britton, Gruber, Immunology of COVID-19: Current State of the Science, Immunity
Van Paassen, Vos, Hoekstra, Corticosteroid use in COVID-19 patients: a systematic review and metaanalysis on clinical outcomes, Crit Care
White, Kosar, Feifer, Variation in SARS-CoV-2 Prevalence in U.S. Skilled Nursing Facilities, J Am Geriatr Soc
Wong, Lui, Sung, Covid-19 and the digestive system, J Gastroenterol Hepatol
Worcel, Ali, Ramos-Pascual, Stirling, Chary, Low mortality from COVID-19 at a nursing facility in France following a combined preventive and active treatment protocol, Ann Palliat Med
Wu, Duan, Luo, Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China, JAMA Ophthalmol
Wu, Xu, Chen, Nervous system involvement after infection with COVID-19 and other coronaviruses, Brain Behav Immun
Xiao, Tang, Zheng, Evidence for Gastrointestinal Infection of SARS-CoV-2, Gastroenterology
Xu, Li, Zhu, Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding, Nat Med
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop