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Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate

Wardeh et al., Journal of Clinical Intensive Care and Medicine, doi:10.29328/journal.jcicm.1001029
May 2020  
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Case series of four ventilated COVID-19 patients treated with sodium bicarbonate inhalation, all showing clinical and radiological improvement, with 2 patients extubated within 24-72 hours.
Wardeh et al., 19 May 2020, China, peer-reviewed, 3 authors. Contact: awardeh1@aol.com, awardeh1@icloud.com.
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Abstract: Case Report More Information Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate *Address for Correspondence: Anas Wardeh, Department of Critical Care Medicine, Uniontown Hospital, Uniontown, PA, USA, Tel: 508-479-4213; Email: awardeh1@aol.com; awardeh1@icloud.com Wardeh A*, Conklin J and Ko M The emergence of COVID-19 worldwide in an unprecedented pandemic. COVID-19 has a signi icant mortality, mostly from acute lung injury. We reviewed the available literature from China and Europe in regard to the behavior of SARS-Cov2 and ability to adhere to the cell wall [1,2]. The evidence based literature describes three component for the virus to grant entry to the target cells including Cathepsin B/L (the viral cap protein needed for initial connectivity to the cell wall), the angiotensin converting enzyme 2 and a low PH environment to allow the irst connectivity of the virus to the cell wall [3]. The goal of our Case study was to prevent SARS- SARS-Cov2 from entering target cells by raising the airways PH using sodium bicarbonate inhalation. The sodium Bicarbonate inhalation (4.2% concentration) has been used safely in Cystic ibrosis (CF) patients with inspissated mucoid impaction [3,4] and in chloride inhalation toxicity by opposing the effect of the low PH induced by the insulting agent [4,5]. It has not been administered for COVID -19 patients particularly prior to this study. Methods Four patients required mechanical ventilation due to COVID-19 pneumonia. All patients have proven positive COVID-19 RNA collected from the airway’s secretions. Each one of the patients received inhaled 4.2% sodium bicarbonate as a salvage therapy. All four patients had severe adult respiratory distress syndrome (ARDS) and required 100 % Fraction of inspired oxygen (FIO2). Due to severe hypoxia despite 100% FIO2, these patients were placed on Positive end expiratory pressure (PEEP) of 15 to maintain their Oxygen saturation at 87% at minimum. Also, a standard PEEP of 15 was used throughout the process to keep the alveoli patent to https://doi.org/10.29328/journal.jcicm.1001029 How to cite this article: Wardeh A, Conklin J, Ko M. Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate. J Clin Intensive Care Med. 2020; 5: 016-019. DOI: 10.29328/journal.jcicm.1001029 Department of Critical Care Medicine, Uniontown Hospital, Uniontown, PA, USA
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Chu, V. McElroy, L. Chu, V. Bauman, B. Whittaker, G. The Avian ' 'Coronavirus Infectious Bronchitis undergoes direct low PH dependent ' 'Fusion activation during entry into the host cells. J Virol. 2006; 80: ' '3180-3188. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16537586', 'DOI': '10.1128/JVI.80.7.3180-3188.2006'}, { 'key': 'ref1', 'doi-asserted-by': 'publisher', 'unstructured': '2. Yong ZY, Huang Y, Ganesh L, Leung K, Kong wp. et al. pH-Dependent ' 'Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by ' 'the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through ' 'DC-SIGN. J Virol. 2004; 78: 5642-5650. PubMed: ' 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415834/', 'DOI': '10.1128/JVI.78.11.5642-5650.2004'}, { 'key': 'ref2', 'doi-asserted-by': 'publisher', 'unstructured': '3. McShane D, Davies JC, Davies MG, Bush A, Geddes DM, et al. Airway ' 'surface PH in subjects with cystic fibrosis. Eur Respir J. 2003; 21: ' '37-42. 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Toth L, Kunos L, Gyorgy L, Wanner A. The effect of airway ' 'alkalinization by nebulized sodium bicarbonate on airway blood flow. ' 'European Res. Journal. 2012; 40: P2143.'}, { 'key': 'ref7', 'unstructured': '8. Chinese SARS Molecular Consortium. Science 10.1126/science.1092002.'}, { 'key': 'ref8', 'doi-asserted-by': 'publisher', 'unstructured': '9. Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, et al. ' 'Severe ARDS due to SARS CoV infection inhibition using spike protein ' 'heptad repeated-derived peptides. Proc Natl Acad Sci USA. 2004; 101: ' '8455-8460. 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