Analgesics
Antiandrogens
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lactoferrin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Peg.. Lambda
Quercetin
Remdesivir
Vitamins

Other
Feedback
Home
Top
Abstract
All alkalinization studies
Meta analysis
 
Feedback
Home
c19early.org COVID-19 treatment researchAlkalinizationAlkalinization (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  

Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate

Wardeh et al., Journal of Clinical Intensive Care and Medicine, doi:10.29328/journal.jcicm.1001029
May 2020  
  Twitter
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Case series of four ventilated COVID-19 patients treated with sodium bicarbonate inhalation, all showing clinical and radiological improvement, with 2 patients extubated within 24-72 hours.
Wardeh et al., 19 May 2020, China, peer-reviewed, 3 authors.
Contact: awardeh1@aol.com, awardeh1@icloud.com.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperAlkalinizationAll
Abstract: Case Report More Information Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate *Address for Correspondence: Anas Wardeh, Department of Critical Care Medicine, Uniontown Hospital, Uniontown, PA, USA, Tel: 508-479-4213; Email: awardeh1@aol.com; awardeh1@icloud.com Wardeh A*, Conklin J and Ko M The emergence of COVID-19 worldwide in an unprecedented pandemic. COVID-19 has a signi icant mortality, mostly from acute lung injury. We reviewed the available literature from China and Europe in regard to the behavior of SARS-Cov2 and ability to adhere to the cell wall [1,2]. The evidence based literature describes three component for the virus to grant entry to the target cells including Cathepsin B/L (the viral cap protein needed for initial connectivity to the cell wall), the angiotensin converting enzyme 2 and a low PH environment to allow the irst connectivity of the virus to the cell wall [3]. The goal of our Case study was to prevent SARS- SARS-Cov2 from entering target cells by raising the airways PH using sodium bicarbonate inhalation. The sodium Bicarbonate inhalation (4.2% concentration) has been used safely in Cystic ibrosis (CF) patients with inspissated mucoid impaction [3,4] and in chloride inhalation toxicity by opposing the effect of the low PH induced by the insulting agent [4,5]. It has not been administered for COVID -19 patients particularly prior to this study. Methods Four patients required mechanical ventilation due to COVID-19 pneumonia. All patients have proven positive COVID-19 RNA collected from the airway’s secretions. Each one of the patients received inhaled 4.2% sodium bicarbonate as a salvage therapy. All four patients had severe adult respiratory distress syndrome (ARDS) and required 100 % Fraction of inspired oxygen (FIO2). Due to severe hypoxia despite 100% FIO2, these patients were placed on Positive end expiratory pressure (PEEP) of 15 to maintain their Oxygen saturation at 87% at minimum. Also, a standard PEEP of 15 was used throughout the process to keep the alveoli patent to https://doi.org/10.29328/journal.jcicm.1001029 How to cite this article: Wardeh A, Conklin J, Ko M. Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate. J Clin Intensive Care Med. 2020; 5: 016-019. DOI: 10.29328/journal.jcicm.1001029 Department of Critical Care Medicine, Uniontown Hospital, Uniontown, PA, USA
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit