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Vitamin D status and COVID-19 prevention in a worker subgroup in Italy

Ubaldi et al., Work, doi:10.3233/WOR-220387
Jan 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Report on vitamin D supplementation with 139 employees in Italy from April to June 2021, showing only one confirmed COVID-19 case (0.7%) and 4 cases of flu-like symptoms, compared to ~7-9% COVID-19 incidence for the same Italian district and period.
Ubaldi et al., 10 Jan 2023, Italy, peer-reviewed, 9 authors, study period April 2021 - June 2021. Contact: federica.valeriani@uniroma4.it.
This PaperVitamin DAll
Vitamin D status and COVID-19 prevention in a worker subgroup in Italy
Francesca Ubaldi, Enrico Montanari, Lory Marika Margarucci, Claudio Caprara, Gianluca Gianfranceschi, Elena Scaramucci, Antonio Piccolella, Federica Valeriani, Vincenzo Romano Spica
Work, doi:10.3233/wor-220387
BACKGROUND: Low levels of vitamin D are widespread in the world's population and associated with sun exposure, genetics, and lifestyles. Office workers in different occupational sectors seem more vulnerable than others. Scientific evidence reports a contribution of vitamin D in resistance to infections, opening to supplementation as a preventive action against pathogens, including SARS-CoV-2. OBJECTIVE: A pilot campaign in the workplace during the coronavirus 2019 (COVID-19) pandemic was conducted based on the preliminary measurement of vitamin D amount and its integration. METHODS: A preventive action to contrast the deficiency of vitamin D was offered to a population of 700 bank employees. Vitamin D supplementation was performed between April and June 2021, on workers (n = 139) and showed 25(OH)D serum levels ≤ 30 ng/ml. Demographic, anthropometric and lifestyle information were collected by survey and changes in the serum 25(OH)D amounts were monitored. RESULTS: The adherence of the target population to the prevention campaign was 21%. 75% of the enrolled workers had low levels of vitamin D. After the intervention, serum vitamin D levels increased (1.28-fold; p = 0.0001) and 80% of the subjects reported optimal values > 30 ng/ml. Only 2.9% reported slight flu-like symptoms, but only 0.7% was confirmed as COVID-19, with respect to a ten-fold higher incidence in the general population. CONCLUSIONS: Vitamin D supplementation can be achieved by simple and noninvasive approaches and can bring along further insights into health literacy on diet and lifestyles, representing an opportunity to protect the population by the widespread state of vitamin deficiency.
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Arch Med Res'}, { 'issue': '3', 'key': '10.3233/WOR-220387_ref42', 'doi-asserted-by': 'crossref', 'first-page': '505', 'DOI': '10.3390/nu14030505', 'article-title': 'Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health ' 'Care Workers', 'volume': '14', 'author': 'Karonova', 'year': '2022', 'journal-title': 'Nutrients'}, { 'key': '10.3233/WOR-220387_ref43', 'doi-asserted-by': 'crossref', 'unstructured': 'Rizzoli R . Vitamin D supplementation: upper limit for safety revisited? 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Drugs in Note: cholecalciferol, ' 'cholecalciferol / calcium salts, calcifediol. 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