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A phase I clinical trial to evaluate the safety of thymoquinone -rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study

Thomas et al., Toxicology Reports, doi:10.1016/j.toxrep.2022.04.020
Apr 2022  
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11th treatment shown to reduce risk in January 2021
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Phase 1 trial of high thymoquinone content (5%) black cumin oil finding treatment to be safe without any major side effects or adverse events. There was a significant reduction in total cholesterol, LDL, and triglycerides, and increased HDL.
Thomas et al., 20 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, peer-reviewed, 6 authors.
This PaperNigella SativaAll
A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study
ME Jestin V Thomas, M E Mohan, Prathibha Prabhakaran, Syam Das S, Balu Maliakel, Krishnakumar I.M.
Toxicology Reports, doi:10.1016/j.toxrep.2022.04.020
Maliakel and IM Krishnakumar, A phase I clinical trial to evaluate the safety of thymoquinone -rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective s t u d y , Toxicology Reports, (2022)
J o u r n a l P r e -p r o o f Declaration of competing interest The authors disclose the following conflict of interests. BlaQmax ® is a patented and registered product of Akay Natural Ingredients, Cochin, India. J.V.T & M.M.E belongs to non-profit research organizations who conducted the study and critically evaluated the data. P.P, S.D.S, B.M and K.I.M belong to the company Akay Natural Ingredients (Cochin, India), who prepared the study drugs, conceived the idea, and approved the protocol. Declaration of interests ☐ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☒The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: The authors disclose the following conflict of interests. BlaQmax ® is a patented and registered product of M/s Akay Natural Ingredients, Cochin, India. J o u r n a l P r e -p r o o f
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