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All Studies   All Outcomes    Recent:   

Emerging SARS-CoV-2 Resistance After Antiviral Treatment

Tamura et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2024.35431
Sep 2024  
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Prospective study of 156 outpatients showing emergent nirmatrelvir resistance mutations with nirmatrelvir treatment, especially in immunosuppressed individuals. Results support the use of combination antiviral therapy and host-directed treatments which may be key strategies in reducing the risk of resistance, especially in high-risk or immunosuppressed patients.
Tamura et al., 25 Sep 2024, prospective, USA, peer-reviewed, median age 56.0, 28 authors, study period May 2021 - October 2023.
This PaperPaxlovidAll
Emerging SARS-CoV-2 Resistance After Antiviral Treatment
BA Trevor J Tamura, PhD Manish C Choudhary, PhD Rinki Deo, BS Fizah Yousuf, Edelstein, Boucau, Glover, Barry Anadela Navarrete Gomez, BA Gregory E Edelstein, PhD Julie Boucau, BA Owen T Glover, MD Mamadou Barry, BA Rebecca F Gilbert, MPH Zahra Reynolds, MD Yijia Li, BSA Dessie Tien, Passell, Su, Drapkin, Abar, Kawano, Sparks, Wallace, Shafer, Siedner, Barczak, Lemieux Tammy D Vyas, MPH Eliza Passell, BA Karry Su, BA Sarah Drapkin, BS Emory G Abar, MD Yumeko Kawano, MD, MMsc Jeffrey A Sparks, MD, MSc Zachary S Wallace, MD Jatin M Vyas, PhD Robert W Shafer, MD Mark J Siedner, MD, MPH Amy K Barczak, MD Jacob E Lemieux, MD, PhD Jonathan Z Li
JAMA Network Open, doi:10.1001/jamanetworkopen.2024.35431
IMPORTANCE Previous studies have identified mutations in SARS-CoV-2 strains that confer resistance to nirmatrelvir, yet how often this resistance arises and its association with posttreatment virologic rebound is not well understood. OBJECTIVE To examine the prevalence of emergent antiviral resistance after nirmatrelvir treatment and its association with virologic rebound. DESIGN, SETTING, AND PARTICIPANTS This cohort study enrolled outpatient adults with acute COVID-19 infection from May 2021 to October 2023. Participants were divided into those who received antiviral therapy and those who did not. The study was conducted at a multicenter health care system in Boston, Massachusetts. EXPOSURE Treatment regimen, including none, nirmatrelvir, and remdesivir. MAIN OUTCOMES AND MEASURES The primary outcome was emergent SARS-CoV-2 antiviral resistance, defined as the detection of antiviral resistance mutations, which were not present at baseline, were previously associated with decreased antiviral efficacy, and emerged during or after completion of a participant's treatment. Next-generation sequencing was used to detect low frequency mutations down to 1% of the total viral population. RESULTS Overall, 156 participants (114 female [73.1%]; median [IQR] age, 56 [38-69] years) were included. Compared with 63 untreated individuals, the 79 who received nirmatrelvir were older and more commonly immunosuppressed. After sequencing viral RNA from participants' anterior nasal swabs, nirmatrelvir resistance mutations were detected in 9 individuals who received nirmatrelvir (11.4%) compared with 2 of those who did not (3.2%) (P = .09). Among the individuals treated with nirmatrelvir, those who were immunosuppressed had the highest frequency of resistance emergence (5 of 22 [22.7%]), significantly greater than untreated individuals (2 of 63 [3.1%]) (P = .01). Similar rates of nirmatrelvir resistance were found in those who had virologic rebound (3 of 23 [13.0%]) vs those who did not (6 of 56 [10.7%]) (P = .86). Most of these mutations (10 of 11 [90.9%]) were detected at low frequencies (<20% of viral population) and reverted to the wild type at subsequent time points. Emerging remdesivir resistance mutations were only detected in immunosuppressed individuals (2 of 14 [14.3%]) but were similarly low frequency and transient. Global Initiative on Sharing All Influenza Data analysis showed no evidence of increased nirmatrelvir resistance in the United States after the authorization of nirmatrelvir. CONCLUSIONS AND RELEVANCE In this cohort study of 156 participants, treatment-emergent nirmatrelvir resistance mutations were commonly detected, especially in individuals who were immunosuppressed. However, these mutations were generally present at low frequencies and were (continued) Key Points Question Is there an increased frequency of SARS-CoV-2 antiviral resistance in individuals receiving antiviral therapy? Findings In this cohort study with 156 participants,..
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{ 'indexed': {'date-parts': [[2024, 9, 26]], 'date-time': '2024-09-26T04:30:10Z', 'timestamp': 1727325010481}, 'reference-count': 31, 'publisher': 'American Medical Association (AMA)', 'issue': '9', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:sec id="ab-zoi241054-4"><jats:title>Importance</jats:title><jats:p>Previous studies ' 'have identified mutations in SARS-CoV-2 strains that confer resistance to nirmatrelvir, yet ' 'how often this resistance arises and its association with posttreatment virologic rebound is ' 'not well understood.</jats:p></jats:sec><jats:sec ' 'id="ab-zoi241054-5"><jats:title>Objective</jats:title><jats:p>To examine the prevalence of ' 'emergent antiviral resistance after nirmatrelvir treatment and its association with virologic ' 'rebound.</jats:p></jats:sec><jats:sec id="ab-zoi241054-6"><jats:title>Design, Setting, and ' 'Participants</jats:title><jats:p>This cohort study enrolled outpatient adults with acute ' 'COVID-19 infection from May 2021 to October 2023. Participants were divided into those who ' 'received antiviral therapy and those who did not. The study was conducted at a multicenter ' 'health care system in Boston, Massachusetts.</jats:p></jats:sec><jats:sec ' 'id="ab-zoi241054-7"><jats:title>Exposure</jats:title><jats:p>Treatment regimen, including ' 'none, nirmatrelvir, and remdesivir.</jats:p></jats:sec><jats:sec ' 'id="ab-zoi241054-8"><jats:title>Main Outcomes and Measures</jats:title><jats:p>The primary ' 'outcome was emergent SARS-CoV-2 antiviral resistance, defined as the detection of antiviral ' 'resistance mutations, which were not present at baseline, were previously associated with ' 'decreased antiviral efficacy, and emerged during or after completion of a participant’s ' 'treatment. Next-generation sequencing was used to detect low frequency mutations down to 1% ' 'of the total viral population.</jats:p></jats:sec><jats:sec ' 'id="ab-zoi241054-9"><jats:title>Results</jats:title><jats:p>Overall, 156 participants (114 ' 'female [73.1%]; median [IQR] age, 56 [38-69] years) were included. Compared with 63 untreated ' 'individuals, the 79 who received nirmatrelvir were older and more commonly immunosuppressed. ' 'After sequencing viral RNA from participants’ anterior nasal swabs, nirmatrelvir resistance ' 'mutations were detected in 9 individuals who received nirmatrelvir (11.4%) compared with 2 of ' 'those who did not (3.2%) (<jats:italic>P</jats:italic>\u2009=\u2009.09). Among the ' 'individuals treated with nirmatrelvir, those who were immunosuppressed had the highest ' 'frequency of resistance emergence (5 of 22 [22.7%]), significantly greater than untreated ' 'individuals (2 of 63 [3.1%]) (<jats:italic>P</jats:italic>\u2009=\u2009.01). Similar rates of ' 'nirmatrelvir resistance were found in those who had virologic rebound (3 of 23 [13.0%]) vs ' 'those who did not (6 of 56 [10.7%]) (<jats:italic>P</jats:italic>\u2009=\u2009.86). Most of ' 'these mutations (10 of 11 [90.9%]) were detected at low frequencies (&amp;amp;lt;20% of viral ' 'population) and reverted to the wild type at subsequent time points. Emerging remdesivir ' 'resistance mutations were only detected in immunosuppressed individuals (2 of 14 [14.3%]) but ' 'were similarly low frequency and transient. Global Initiative on Sharing All Influenza Data ' 'analysis showed no evidence of increased nirmatrelvir resistance in the United States after ' 'the authorization of nirmatrelvir.</jats:p></jats:sec><jats:sec ' 'id="ab-zoi241054-10"><jats:title>Conclusions and Relevance</jats:title><jats:p>In this cohort ' 'study of 156 participants, treatment-emergent nirmatrelvir resistance mutations were commonly ' 'detected, especially in individuals who were immunosuppressed. However, these mutations were ' 'generally present at low frequencies and were transient in nature, suggesting a low risk for ' 'the spread of nirmatrelvir resistance in the community with the current variants and drug ' 'usage patterns.</jats:p></jats:sec>', 'DOI': '10.1001/jamanetworkopen.2024.35431', 'type': 'journal-article', 'created': {'date-parts': [[2024, 9, 25]], 'date-time': '2024-09-25T21:40:20Z', 'timestamp': 1727300420000}, 'page': 'e2435431', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Emerging SARS-CoV-2 Resistance After Antiviral Treatment', 'prefix': '10.1001', 'volume': '7', 'author': [ { 'given': 'Trevor J.', 'family': 'Tamura', 'sequence': 'first', 'affiliation': [{'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}]}, { 'given': 'Manish C.', 'family': 'Choudhary', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Harvard Medical School, Boston, Massachusetts'}]}, { 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'name': 'Ragon Institute of Massachusetts General Hospital, MIT and ' 'Harvard, Cambridge'}]}, { 'given': 'Mamadou', 'family': 'Barry', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Rebecca F.', 'family': 'Gilbert', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Zahra', 'family': 'Reynolds', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Yijia', 'family': 'Li', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Massachusetts General Hospital, Boston'}, { 'name': 'University of Pittsburgh Medical Center, Pittsburgh, ' 'Pennsylvania'}]}, { 'given': 'Dessie', 'family': 'Tien', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Tammy D.', 'family': 'Vyas', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Eliza', 'family': 'Passell', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Karry', 'family': 'Su', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Sarah', 'family': 'Drapkin', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Emory G.', 'family': 'Abar', 'sequence': 'additional', 'affiliation': [{'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Yumeko', 'family': 'Kawano', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Harvard Medical School, Boston, Massachusetts'}]}, { 'given': 'Jeffrey A.', 'family': 'Sparks', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Harvard Medical School, Boston, Massachusetts'}]}, { 'given': 'Zachary S.', 'family': 'Wallace', 'sequence': 'additional', 'affiliation': [ {'name': 'Harvard Medical School, Boston, Massachusetts'}, {'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Jatin M.', 'family': 'Vyas', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Massachusetts General Hospital, Boston'}, {'name': 'Broad Institute, Cambridge, Massachusetts'}]}, { 'given': 'Robert W.', 'family': 'Shafer', 'sequence': 'additional', 'affiliation': [{'name': 'Stanford University School of Medicine, Palo Alto, California'}]}, { 'given': 'Mark J.', 'family': 'Siedner', 'sequence': 'additional', 'affiliation': [ {'name': 'Harvard Medical School, Boston, Massachusetts'}, {'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Amy K.', 'family': 'Barczak', 'sequence': 'additional', 'affiliation': [ {'name': 'Harvard Medical School, Boston, Massachusetts'}, { 'name': 'Ragon Institute of Massachusetts General Hospital, MIT and ' 'Harvard, Cambridge'}, {'name': 'Massachusetts General Hospital, Boston'}]}, { 'given': 'Jacob E.', 'family': 'Lemieux', 'sequence': 'additional', 'affiliation': [ {'name': 'Harvard Medical School, Boston, Massachusetts'}, {'name': 'Massachusetts General Hospital, Boston'}, {'name': 'Broad Institute, Cambridge, Massachusetts'}]}, { 'given': 'Jonathan Z.', 'family': 'Li', 'sequence': 'additional', 'affiliation': [ {'name': 'Brigham and Women’s Hospital, Boston, Massachusetts'}, {'name': 'Harvard Medical School, Boston, Massachusetts'}]}, {'name': 'POSITIVES Study Team', 'sequence': 'additional', 'affiliation': []}], 'member': '10', 'published-online': {'date-parts': [[2024, 9, 25]]}, 'reference': [ { 'issue': '15', 'key': 'zoi241054r2', 'doi-asserted-by': 'publisher', 'first-page': '1397', 'DOI': '10.1056/NEJMoa2118542', 'article-title': 'Oral nirmatrelvir for high-risk, nonhospitalized adults with 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Commun'}, { 'issue': '3', 'key': 'zoi241054r17', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0261045', 'article-title': 'Coronavirus Resistance Database (CoV-RDB): SARS-CoV-2 susceptibility to ' 'monoclonal antibodies, convalescent plasma, and plasma from vaccinated ' 'persons.', 'volume': '17', 'author': 'Tzou', 'year': '2022', 'journal-title': 'PLoS One'}, { 'issue': '6', 'key': 'zoi241054r19', 'doi-asserted-by': 'publisher', 'first-page': '1558', 'DOI': '10.1093/jac/dkab062', 'article-title': 'Impact of pre-existing drug resistance on risk of virological failure ' 'in South Africa.', 'volume': '76', 'author': 'Li', 'year': '2021', 'journal-title': 'J Antimicrob Chemother'}, { 'issue': '49', 'key': 'zoi241054r22', 'doi-asserted-by': 'publisher', 'first-page': '1049', 'DOI': '10.46234/ccdcw2021.255', 'article-title': 'GISAID’s role in pandemic response.', 'volume': '3', 'author': 'Khare', 'year': '2021', 'journal-title': 'China CDC Wkly'}, { 'issue': '731', 'key': 'zoi241054r23', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/scitranslmed.adk1599', 'article-title': 'SARS-CoV-2 viral clearance and evolution varies by type and severity of ' 'immunodeficiency.', 'volume': '16', 'author': 'Li', 'year': '2024', 'journal-title': 'Sci Transl Med'}, { 'issue': '2', 'key': 'zoi241054r24', 'doi-asserted-by': 'publisher', 'first-page': '352', 'DOI': '10.1093/cid/ciad494', 'article-title': 'Nirmatrelvir resistance-de novo E166V/L50V mutations in an ' 'immunocompromised patient treated with prolonged nirmatrelvir/ritonavir ' 'monotherapy leading to clinical and virological treatment failure—a ' 'case report.', 'volume': '78', 'author': 'Zuckerman', 'year': '2024', 'journal-title': 'Clin Infect Dis'}, { 'issue': '11', 'key': 'zoi241054r25', 'doi-asserted-by': 'publisher', 'first-page': '813', 'DOI': '10.1016/j.medj.2023.08.001', 'article-title': 'Multidrug-resistant mutations to antiviral and antibody therapy in an ' 'immunocompromised patient infected with 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'Clin Infect Dis', 'DOI': '10.1093/cid/ciad696'}, { 'issue': '8', 'key': 'zoi241054r29', 'doi-asserted-by': 'publisher', 'first-page': '845', 'DOI': '10.1016/S1473-3099(24)00171-3', 'article-title': 'The persistence of SARS-CoV-2 in tissues and its association with long ' 'COVID symptoms: a cross-sectional cohort study in China.', 'volume': '24', 'author': 'Zuo', 'year': '2024', 'journal-title': 'Lancet Infect Dis'}, { 'issue': '12', 'key': 'zoi241054r30', 'doi-asserted-by': 'publisher', 'first-page': '2068', 'DOI': '10.1038/s41590-023-01661-4', 'article-title': 'SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled ' 'by IFN-? and NK cells.', 'volume': '24', 'author': 'Huot', 'year': '2023', 'journal-title': 'Nat Immunol'}, { 'issue': '10', 'key': 'zoi241054r31', 'doi-asserted-by': 'publisher', 'first-page': '1616', 'DOI': '10.1038/s41590-023-01601-2', 'article-title': 'SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).', 'volume': '24', 'author': 'Proal', 'year': '2023', 'journal-title': 'Nat Immunol'}, { 'key': 'zoi241054r1', 'unstructured': 'US Food and Drug Administration. 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Accessed ' 'August 22, 2024. https://github.com/hivdb/codfreq'}, { 'key': 'zoi241054r20', 'unstructured': 'Stanford University Coronavirus Antiviral & Resistance Database. ' 'SARS-CoV-2 resistance mutations—3CLpro inhibitors. Accessed August 22, ' '2024. https://covdb.stanford.edu/drms/3clpro/'}, { 'key': 'zoi241054r21', 'unstructured': 'Stanford University Coronavirus Antiviral & Resistance Database. ' 'SARS-CoV-2 resistance mutations—RdRP inhibitors. Accessed August 22, ' '2024. https://covdb.stanford.edu/drms/rdrp/'}], 'container-title': 'JAMA Network Open', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2824050/tamura_2024_oi_241054_1726669148.41936.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 9, 25]], 'date-time': '2024-09-25T21:40:23Z', 'timestamp': 1727300423000}, 'score': 1, 'resource': {'primary': {'URL': 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824050'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 9, 25]]}, 'references-count': 31, 'journal-issue': {'issue': '9', 'published-print': {'date-parts': [[2024, 9, 3]]}}, 'URL': 'http://dx.doi.org/10.1001/jamanetworkopen.2024.35431', 'relation': {}, 'ISSN': ['2574-3805'], 'subject': [], 'container-title-short': 'JAMA Netw Open', 'published': {'date-parts': [[2024, 9, 25]]}}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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