The effect of vitamin D deficiency on platelet parameters in patients with COVID-19
Amirhossein Talebzadeh, Hadi Ghaffari, Kazem Ghaffari, Sorur Yazdanpanah, Bahman Yousefi Goltappeh, Majid Eslami, Ali Ghasemi
Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2024.1360075
Introduction: Since there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value of these parameters in cases of vitamin D deficiency. Methods: Seven hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. Patients were divided into two groups: those with and without vitamin D deficiency. The associations between platelet indices and vitamin D levels were analyzed by Pearson's correlation analysis and a one-way ANOVA test. Results: Platelet count and mean platelet volume (MPV) were significantly higher in the patients with vitamin D deficiency than in the patients without vitamin D deficiency. There was a significant negative correlation between platelet count and MPV with vitamin D levels in patients with vitamin D deficiency (r = -0.835, P = 0.001 & r = -0.324, P = 0.042, respectively). Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the patients. Discussion: The aforementioned results imply that maintaining an elevated concentration of vitamin D in COVID-19 patients is important because it is associated with a decrease in MPV, which in turn reduces susceptibility to diseases such as coronary artery disease.
Ethics statement Ethical principles were followed based on the ethical protocol approved by the Ethics Committee at Semnan University of Medical Sciences, Semnan, Iran (IR.SEMUMS.REC.1401.309). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.
Author contributions AT: Data curation, Investigation, Writingoriginal draft. HG: Conceptualization, Methodology, Visualization, Writingoriginal draft. KG: Software, Validation, Writingoriginal draft. SY: Formal analysis, Methodology, Software, Writingoriginal draft. BY: Project administration, Resources, Supervision, Writingoriginal
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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'abstract': '<jats:sec><jats:title>Introduction</jats:title><jats:p>Since there is very little information '
'about the relationship between platelet parameters and vitamin D concentration in patients '
'with COVID-19, the aim of this study is to investigate the relationship between serum vitamin '
'D level and platelet parameters in patients with COVID-19 and to compare these parameters in '
'patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value '
'of these parameters in cases of vitamin D '
'deficiency.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Seven '
'hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. '
'Patients were divided into two groups: those with and without vitamin D deficiency. The '
'associations between platelet indices and vitamin D levels were analyzed by Pearson’s '
'correlation analysis and a one-way ANOVA '
'test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Platelet count and '
'mean platelet volume (MPV) were significantly higher in the patients with vitamin D '
'deficiency than in the patients without vitamin D deficiency. There was a significant '
'negative correlation between platelet count and MPV with vitamin D levels in patients with '
'vitamin D deficiency (r = -0.835, P = 0.001 &amp; r = -0.324, P = 0.042, respectively). '
'Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the '
'patients.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>The '
'aforementioned results imply that maintaining an elevated concentration of vitamin D in '
'COVID-19 patients is important because it is associated with a decrease in MPV, which in turn '
'reduces susceptibility to diseases such as coronary artery disease.</jats:p></jats:sec>',
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