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Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study

Sutkowska et al., Journal of Clinical Medicine, doi:10.3390/jcm12124046, NCT05200767
Jun 2023  
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Mortality 62% Improvement Relative Risk Recovery 61% Exercise for COVID-19  Sutkowska et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Prospective study of 131 patients in Poland (Jan - Feb 2022) Lower mortality (p=0.21) and improved recovery (p=0.19), not sig. c19early.org Sutkowska et al., J. Clinical Medicine, Jun 2023 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Prospective study of 131 hospitalized patients in Poland, showing lower mortality and improved recovery with a history of higher physical activity.
risk of death, 62.0% lower, HR 0.38, p = 0.21, high activity levels 71, low activity levels 60, inverted to make HR<1 favor high activity levels, IPAQ 1/2 vs. IPAQ 0, Cox proportional hazards.
risk of no recovery, 61.0% lower, HR 0.39, p = 0.19, high activity levels 71, low activity levels 60, IPAQ 1/2 vs. IPAQ 0, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sutkowska et al., 14 Jun 2023, prospective, Poland, peer-reviewed, 14 authors, study period 31 January, 2022 - 11 February, 2022, trial NCT05200767 (history). Contact: edyta.sutkowska@umw.edu.pl (corresponding author), astanek@tlen.pl, grzegorz.k.jakubiak@gmail.com, katarzyna.madziarska@umw.edu.pl, mmadziarski@usk.wroc.pl, ksutkowska@usk.wroc.pl, adrianna.borowkow@gmail.com, justyna.mazurek@umw.edu.pl.
This PaperExerciseAll
Physical Activity Modifies the Severity of COVID-19 in Hospitalized Patients—Observational Study
Edyta Sutkowska, Agata Stanek, Katarzyna Madziarska, Grzegorz K Jakubiak, Janusz Sokołowski, Marcin Madziarski, Karolina Sutkowska-Stępień, Karolina Biernat, Justyna Mazurek, Adrianna Borowkow-Bulek, Jakub Czyżewski, Gabriela Wilk, Arkadiusz Jagasyk, Dominik Marciniak
Journal of Clinical Medicine, doi:10.3390/jcm12124046
Background and aim: Physical activity (PA) can modulate the immune response, but its impact on infectious disease severity is unknown. We assess if the PA level impacts the severity of COVID-19. Methods: Prospective, cohort study for adults hospitalized due to COVID-19, who filled out the International Physical Activity Questionnaire (IPAQ). Disease severity was expressed as death, transfer to intensive care unit (ICU), oxygen therapy (OxTh), hospitalization length, complications, C-reactive protein, and procalcitonin level. Results: Out of 326 individuals, 131 (57; 43.51% women) were analyzed: age: median-70; range: 20-95; BMI: mean-27.18 kg/m 2 ; and SD: ±4.77. During hospitalization: 117 (83.31%) individuals recovered, nine (6.87%) were transferred to ICU, five (3.82%) died, and 83 (63.36%) needed OxTh. The median for the hospital stay was 11 (range: 3-49) for discharged patients, and mean hospitalization length was 14 (SD: ±5.8312) for deaths and 14.22 days (SD: ±6.92) for ICU-transferred patients. The median for MET-min/week was 660 (range: 0-19,200). Sufficient or high PA was found in recovered patients but insufficient PA was observed in dead or ICU-transferred patients (p = 0.03). The individuals with poor PA had a higher risk of death (HR = 2.63; ±95%CI 0.58-11.93; p = 0.037). OxTh was used more often in the less active individuals (p = 0.03). The principal component analysis confirmed a relationship between insufficient PA and an unfavorable course of the disease. Conclusion: A higher level of PA is associated with a milder course of COVID-19.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflict of interest.
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Disease ' 'severity was expressed as death, transfer to intensive care unit (ICU), oxygen therapy ' '(OxTh), hospitalization length, complications, C-reactive protein, and procalcitonin level. ' 'Results: Out of 326 individuals, 131 (57; 43.51% women) were analyzed: age: median—70; range: ' '20–95; BMI: mean—27.18 kg/m²; and SD: ±4.77. During hospitalization: 117 (83.31%) individuals ' 'recovered, nine (6.87%) were transferred to ICU, five (3.82%) died, and 83 (63.36%) needed ' 'OxTh. The median for the hospital stay was 11 (range: 3–49) for discharged patients, and mean ' 'hospitalization length was 14 (SD: ±5.8312) for deaths and 14.22 days (SD: ±6.92) for ' 'ICU-transferred patients. The median for MET-min/week was 660 (range: 0–19,200). Sufficient ' 'or high PA was found in recovered patients but insufficient PA was observed in dead or ' 'ICU-transferred patients (p = 0.03). The individuals with poor PA had a higher risk of death ' '(HR = 2.63; ±95%CI 0.58–11.93; p = 0.037). 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