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Summary of COVID-19 quercetin studies

Studies   Meta Analysis   Hide extended summaries

49 patient quercetin late treatment RCT: 91% lower combined mortality/ICU admission (p=0.02), 89% lower ventilation (p=0.05), 89% lower ICU admission (p=0.05), and 73% higher hospital discharge (p=0.07).
RCT 49 hospitalized COVID-19 patients, 25 treated with curcumin and quercetin, shower lower mortality/ICU admission and improved recovery with treatment. All patients received vitamin D. 336mg curcumin, 520mg quercetin, and 18μg vitamin D3 daily for 14 days. The control arm received 20μg vitamin D3 daily. Baseline fever favored treatment while vaccination favored control.

Jun 2023, Frontiers in Nutrition, https://www.frontiersin.org/articles/10.3389/fnut.2023.1137407/full, https://c19p.org/gerain

120 patient quercetin prophylaxis RCT: 93% fewer symptomatic cases (p=0.04).
RCT 120 healthcare workers, 60 treated with quercetin phytosome, showing lower risk of cases with treatment. Quercetin phytosome 250mg twice a day.

Jan 2022, Life, https://www.mdpi.com/2075-1729/12/1/66/htm, https://c19p.org/rondanelli

152 patient quercetin early treatment RCT: 86% lower mortality (p=0.25), 94% lower ICU admission (p=0.006), and 68% lower hospitalization (p=0.003).
RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.

Jun 2021, Int. J. General Medicine, https://www.dovepress.com/possible-therapeutic-effects-of-adjuvant-quercetin-supplementation-aga-peer-reviewed-fulltext-article-IJGM#, https://c19p.org/dipierro

60 patient quercetin late treatment RCT: 86% lower mortality (p=0.24) and 32% faster recovery (p=0.04).
Small RCT with 60 severe hospitalized patients in Iran, 30 treated with quercetin, showing shorter time until discharge. All patients received remdesivir or favipiravir, and vitamin C, vitamin D, famotidine, zinc, dexamethasone, and magnesium (depending on serum levels). Quercetin 1000mg daily for 7 days. IRCT20200419047128N2.

Dec 2021, European J. Pharmacology, https://www.sciencedirect.com/science/article/pii/S0014299921007718, https://c19p.org/shohan

113 patient quercetin prophylaxis study: 94% fewer cases (p=0.003).
Retrospective 113 outpatients, 53 (patient choice) treated with zinc, quercetin, vitamin C/D/E, l-lysine, and quina, showing lower cases with treatment. Results are subject to selection bias and limited information on the groups is provided. See [journals.sagepub.com].

Jul 2021, J. Evidence-Based Integrative Medicine, https://journals.sagepub.com/doi/full/10.1177/2515690X211026193, https://c19p.org/margolinq

113 patient quercetin prophylaxis RCT: 92% fewer cases (p=0.03).
Small prophylaxis RCT with 113 patients showing fewer cases with quercetin + vitamin C + bromelain prophylaxis. NCT04377789. Note that this paper disappeared from SSRN without explanation.

Nov 2020, SSRN, https://europepmc.org/article/ppr/ppr239932, https://c19p.org/arslan

100 patient quercetin early treatment RCT: 37% improved recovery (p=0.007) and 58% improved viral clearance (p<0.0001).
RCT 100 outpatients in Pakistan, 50 treated with quercetin phytosome, showing faster viral clearance and improved recovery with treatment. Patients in the treatment group were significantly younger (41 vs. 54).

Jan 2023, Frontiers in Pharmacology, https://www.frontiersin.org/articles/10.3389/fphar.2022.1096853/full, https://c19p.org/dipierro5

50 patient quercetin early treatment RCT: 33% improved recovery (p=0.15) and 50% improved viral clearance (p=0.009).
RCT 50 COVID+ outpatients in Pakistan, 25 treated with curcumin, quercetin, and vitamin D, showing significantly faster viral clearance, significantly improved CRP, and faster resolution of acute symptoms (p=0.154). 168mg curcumin, 260mg quercetin and 360IU cholecalciferol.

Apr 2022, Frontiers in Pharmacology, https://www.frontiersin.org/articles/10.3389/fphar.2022.898062/full, https://c19p.org/khan4q

200 patient quercetin late treatment RCT: 29% improved recovery (p=0.5).
RCT 200 patients in Ukraine, 99 treated with IV quercetin/polyvinylirolidone followed by oral quercetin/pectin, showing improved recovery with treatment.

Aug 2021, Zaporozhye Med. J., http://zmj.zsmu.edu.ua/article/view/231714, https://c19p.org/zupanets

50 patient quercetin early treatment RCT: 29% improved recovery (p=0.11) and 91% improved viral clearance (p=0.05).
Small RCT with 50 outpatients, 25 treated with curcumin, quercetin, and vitamin D, showing improved recovery and viral clearance with treatment. 168mg curcumin, 260mg, 360IU vitamin D3 daily for 14 days.

Jan 2023, Frontiers in Nutrition, https://www.frontiersin.org/articles/10.3389/fnut.2022.1023997/full, https://c19p.org/dinujjanq

429 patient quercetin late treatment RCT: 94% lower ICU admission (p=0.39) and 78% higher hospital discharge (p=0.1).
RCT 447 moderate-to-severe hospitalized patients in Turkey, 52 treated with quercetin, bromelain, and vitamin C, showing no statistically significant difference in clinical outcomes.

Jan 2021, Turk. J. Biol.-529, https://journals.tubitak.gov.tr/biology/vol45/iss7/13/, https://c19p.org/onal
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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