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Summary of COVID-19 bamlanivimab/etesevimab studies

Studies   Meta Analysis   Hide extended summaries

1,035 patient bamlanivimab/etesevimab early treatment RCT: 95% lower mortality (p=0.002), 70% lower combined mortality/hospitalization (p=0.0002), 11% faster recovery (p=0.007), and 67% improved viral clearance (p<0.0001).
Results from the BLAZE-1 RCT of combined bamlanivimab/etesevimab, showing significantly lower mortality and combined mortality/hospitalization with treatment. NCT04427501.

Oct 2021, New England J. Medicine, https://www.nejm.org/doi/10.1056/NEJMoa2102685, https://c19p.org/dougan

153 patient bamlanivimab/etesevimab early treatment RCT: 71% fewer combined hospitalization/ER visits (p=0.05).
RCT for LY-CoV555 monotherapy and LY-CoV555/LY-CoV016 combination therapy with 592 patients showing lower hospitalization/ER visits with treatment. For viral load at day 11, a statistically significant reduction was found with combination therapy but not monotherapy.

Jan 2021, JAMA, https://jamanetwork.com/journals/jama/fullarticle/2775647, https://c19p.org/gottlieb

75 patient bamlanivimab/etesevimab early treatment study: 89% lower mortality (p=0.01) and 86% lower progression (p=0.002).
Retrospective 75 COVID+ patients in a skilled nursing facility in the USA, 56 treated within a median of 2 days from symptom onset with bamlanivimab, showing significantly lower mortality with treatment.

Feb 2022, J. the American Geriatrics Society, https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jgs.17705, https://c19p.org/dale

965 patient bamlanivimab/etesevimab prophylaxis RCT: 57% fewer symptomatic cases (p=0.0002).
Press release on the BLAZE-2 trial at nursing homes showing significantly lower symptomatic COVID-19 with treatment.

Jan 2021, Lilly, Press Release, https://investor.lilly.com/news-releases/news-release-details/lillys-neutralizing-antibody-bamlanivimab-ly-cov555-prevented, https://c19p.org/lilly3

6,015 patient bamlanivimab/etesevimab early treatment study: 80% lower mortality (p=0.09), 53% lower hospitalization (p<0.0001), and 27% fewer combined hospitalization/ER visits (p<0.0001).
Retrospective 479 patients treated with bamlanivimab showing lower mortality, hospital admission, and emergency department visits with treatment. Authors incorrectly state that "no other COVID-19 therapies for ambulatory patients have proven effective".

Jun 2021, Open Forum Infectious Diseases, https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab331/6308074, https://c19p.org/webb

468 patient bamlanivimab/etesevimab late treatment study: 67% lower mortality (p=0.05), 64% lower combined mortality/hospitalization (p=0.0003), and 61% lower hospitalization (p=0.001).
Retrospective 234 patients receiving bamlanivimab and 234 matched controls, showing lower hospitalization and mortality with treatment. Greater benefit was seen with administration within 4 days of their positive COVID-19 test.

Mar 2021, medRxiv, https://www.medrxiv.org/content/10.1101/2021.03.25.21254322v1, https://c19p.org/bariola

3,621 patient bamlanivimab/etesevimab late treatment study: 74% lower mortality (p=0.11), 49% lower ICU admission (p=0.1), and 37% lower hospitalization (p=0.01).
Retrospective 2,335 bamlanivimab patients and 2,335 PSM controls in the USA, showing significantly lower hospitalization with treatment.

Sep 2021, J. Clinical Investigation, https://www.jci.org/articles/view/151697, https://c19p.org/ganesh

6,117 patient bamlanivimab/etesevimab early treatment study: 80% lower mortality (p=0.08) and 39% lower hospitalization (p=0.0004).
Retrospective 780 bamlanivimab patients and 5,337 patients not receiving treatment, showing lower hospitalization and ER visits with treatment.

Jun 2021, Open Forum Infectious Diseases, https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofab305/6295837, https://c19p.org/corwin

317 patient bamlanivimab/etesevimab late treatment RCT: 25% lower hospitalization (p=0.6), 14% slower recovery (p=0.97), 1% higher progression (p=1), and 26% improved viral clearance (p=0.002).
RCT 317 outpatients in the USA showing faster viral load and inflammatory biomarker decline, but no significant differences in clinical outcomes.

Aug 2022, Nature Communications, https://www.nature.com/articles/s41467-022-32551-2, https://c19p.org/chew

279 patient bamlanivimab/etesevimab early treatment study: 30% lower hospitalization (p=0.6) and 42% improvement (p=0.04).
Retrospective 136 outpatients showing bamlanivimab reduced emergency department visits at 28 days, but not hospitalizations, compared to a control group prior to authoritzation in patients with mild to moderate COVID-19.

Nov 2021, Cureus, https://www.cureus.com/articles/74418-real-world-utilization-of-bamlanivimab-at-a-rural-community-hospital, https://c19p.org/leavitt

46 patient bamlanivimab/etesevimab early treatment study: 62% fewer combined hospitalization/ER visits (p=0.22).
Retrospective 40 outpatients showing improvement in symptoms and lower risk of hospitalization/ER visits with bamlanivimab, without statistical significance. Different counts for hospitalization are provided in the abstract and text: "Three of 40 (7.5%) patients in the treatment group required inpatient admission" and "In the treatment group, 4 of 40 (10%) patients were hospitalized after infusion."

May 2021, Military Medicine, https://academic.oup.com/milmed/article/187/Special%20Issue_13/e1509/6276449, https://c19p.org/karr

1,257 patient bamlanivimab/etesevimab early treatment study: 65% lower hospitalization (p=0.04).
Retrospective database analysis of 1257 PCR+ outpatients with age ≥65, BMI≥35, 191 receiving bamlanivimab via lottery. Authors note that the alpha variant was most common during the study period, and that efficacy against other variants can be much lower. Authors note confounding due to prioritization in the lottery and differential reporting in the database.

Nov 2021, Open Forum Infectious Diseases, https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab546/6420437, https://c19p.org/rubin

bamlanivimab/etesevimab early treatment study: 51% lower hospitalization (p=0.06).
Retrospective 395 patients in the USA receiving casirivimab/imdevimab or bamlanivimab, showing lower risk of hospitalization with treatment, statistically significant for casirivimab/imdevimab.

Mar 2022, J. the National Comprehensive Cancer Network, https://jnccn.org/view/journals/jnccn/20/3.5/article-pHSR22-178.xml, https://c19p.org/wildenl

2,571 patient bamlanivimab/etesevimab early treatment study: 15% lower combined mortality/hospitalization (p=0.54).
Retrospective 2,571 patients treated with mAbs in the USA, and 5,135 control patients, showing lower combined mortality/hospitalization for bamlanivimab, bamlanivimab/etesevimab, casirivimab/imdevimab, sotrovimab, and bebtelovimab, with statistical significance only for casirivimab/imdevimab.

Apr 2023, Annals of Internal Medicine, https://www.acpjournals.org/doi/10.7326/M22-1286, https://c19p.org/kipl

11,434 patient bamlanivimab/etesevimab early treatment study: 7% higher mortality (p=0.86), 17% lower ICU admission (p=0.51), and 24% lower hospitalization (p=0.0005).
Retrospective 2,879 patients and matched controls in the USA, showing significantly lower mortality and hospitalization with monoclonal antibody treatment (bamlanivimab, bamlanivimab/etesevimab, or casirivimab/imdevimab). There was significantly lower hospitalization with casirivimab/imdevimab compared to bamlanivimab or bamlanivimab/etesevimab. PSM and multivariate analysis is only provided for all treatments combined.

Oct 2021, Open Forum Infectious Diseases, https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab512/6384727, https://c19p.org/cooper

438 patient bamlanivimab/etesevimab early treatment study: 52% lower hospitalization (p=0.01) and 20% lower progression (p=0.52).
Retrospective 438 patients in the USA, 253 treated with bamlanivimab, showing significantly lower hospitalization with treatment.

Jan 2022, Infectious Diseases in Clinical Practice, https://journals.lww.com/10.1097/IPC.0000000000001109, https://c19p.org/delasobera

758 patient bamlanivimab/etesevimab late treatment PSM study: no change in mortality (p=1), 4% higher hospitalization (p=0.86), and 5% more combined hospitalization/ER visits (p=0.86).
Retrospective 379 bamlanivimab patients and 379 matched controls in the USA, showing no significant differences with treatment.

Jan 2022, Infectious Diseases in Clinical Practice, https://journals.lww.com/10.1097/IPC.0000000000001130, https://c19p.org/priest

714 patient bamlanivimab/etesevimab early treatment RCT: 12% faster recovery and 9% improved viral clearance (p<0.0001).
RCT showing improved viral clearance with bamlanivimab/etesevimab combined with bebtelovimab. Results refer to the placebo controlled portion of the trial.

Mar 2022, medRxiv, https://www.medrxiv.org/content/10.1101/2022.03.10.22272100, https://c19p.org/dougan2l

314 patient bamlanivimab/etesevimab late treatment RCT: 100% higher mortality (p=0.22).
Late stage RCT of LY-CoV555 added to remdesivir, showing non-statistically significant higher mortality with the addition of LY-CoV555.

Dec 2020, ACTIV-3/TICO LY-CoV555 study group, NEJM, https://www.nejm.org/doi/full/10.1056/NEJMoa2033130, https://c19p.org/activ3
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