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c19early.org COVID-19 treatment researchCrizanlizumabCrizanlizumab (more..)
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Summary of COVID-19 crizanlizumab studies

Studies   Meta Analysis   Hide extended summaries

42 patient crizanlizumab late treatment RCT: 35% lower hospital discharge (p=0.16).
RCT 54 hospitalized COVID-19 patients showing crizanlizumab treatment reduced soluble P-selectin levels, increased D-dimer levels, and decreased prothrombin fragment 1.2 compared to placebo. There were no significant differences in inflammatory markers, clinical outcomes, or adverse events between groups. The authors hypothesize that crizanlizumab may induce endogenous thrombolysis in COVID-19.

Dec 2021, JACC: Basic to Translational Science, https://www.sciencedirect.com/science/article/pii/S2452302X21003156, https://c19p.org/leucker

421 patient crizanlizumab late treatment RCT: 33% higher mortality (p=0.24) and 43% worse results (p=0.16).
RCT 422 hospitalized COVID-19 patients showing no significant difference in mortality or organ support-free days with crizanlizumab, a P-selectin inhibitor. There was a trend towards increased mortality with crizanlizumab. The study was stopped early for futility.

Aug 2023, Circulation, https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065190, https://c19p.org/solomon
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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