Summary of COVID-19 BMS mAbs studies
Studies
Meta Analysis
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211 patient BMS mAbs early treatment RCT: 17% lower progression (p=0.03), 20% faster recovery (p=0.19), and 4% improved viral clearance (p=0.45).
RCT 211 outpatients with COVID-19 showing no significant difference in time to symptom improvement with subcutaneous BMS-986414 (C135-LS, ogalvibart) and BMS-986413 (C144-LS, crexavibart) monoclonal antibodies compared to placebo. There was a trend favoring the treatment arm and participants on the monoclonal antibodies were less likely to have worsening symptoms. No significant differences were found for the proportion of patients with undetectable viral load or hospitalization. The study included a low-risk population, which may have limited the treatment effect. Higher early plasma monoclonal antibody concentrations were associated with more favorable outcomes, suggesting the subcutaneous route may not have achieved adequate concentrations quickly enough at the site of infection.
May 2024, Pathogens & Immunity, https://europepmc.org/article/MED/38746756, https://c19p.org/corado
211 patient BMS mAbs early treatment RCT: 17% lower progression (p=0.03), 20% faster recovery (p=0.19), and 4% improved viral clearance (p=0.45).
RCT 211 outpatients with COVID-19 showing no significant difference in time to symptom improvement with subcutaneous BMS-986414 (C135-LS, ogalvibart) and BMS-986413 (C144-LS, crexavibart) monoclonal antibodies compared to placebo. There was a trend favoring the treatment arm and participants on the monoclonal antibodies were less likely to have worsening symptoms. No significant differences were found for the proportion of patients with undetectable viral load or hospitalization. The study included a low-risk population, which may have limited the treatment effect. Higher early plasma monoclonal antibody concentrations were associated with more favorable outcomes, suggesting the subcutaneous route may not have achieved adequate concentrations quickly enough at the site of infection.
May 2024, Pathogens & Immunity, https://europepmc.org/article/MED/38746756, https://c19p.org/corado
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