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c19early.org COVID-19 treatment researchBMS mAbsBMS mAbs (more..)
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Summary of COVID-19 BMS mAbs studies

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211 patient BMS mAbs early treatment RCT: 17% lower progression (p=0.03), 20% faster recovery (p=0.19), and 4% improved viral clearance (p=0.45).
RCT 211 outpatients with COVID-19 showing no significant difference in time to symptom improvement with subcutaneous BMS-986414 (C135-LS, ogalvibart) and BMS-986413 (C144-LS, crexavibart) monoclonal antibodies compared to placebo. There was a trend favoring the treatment arm and participants on the monoclonal antibodies were less likely to have worsening symptoms. No significant differences were found for the proportion of patients with undetectable viral load or hospitalization. The study included a low-risk population, which may have limited the treatment effect. Higher early plasma monoclonal antibody concentrations were associated with more favorable outcomes, suggesting the subcutaneous route may not have achieved adequate concentrations quickly enough at the site of infection.

May 2024, Pathogens & Immunity, https://europepmc.org/article/MED/38746756, https://c19p.org/corado
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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