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c19early.org COVID-19 treatment researchAmbavirumab/romlusevimabAmbavir../r.. (more..)
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Summary of COVID-19 ambavirumab studies

Studies   Meta Analysis   Hide extended summaries

837 patient ambavirumab early treatment RCT: 89% lower mortality (p=0.02), 73% lower hospitalization (p<0.0001), and 79% lower combined mortality/hospitalization (p<0.0001).
RCT 837 non-hospitalized high-risk COVID-19 patients showing 78% reduction in hospitalization and death with BRII-196/BRII-198 (monoclonal antibodies). Study was terminated early. BRII-196/BRII-198 had fewer grade 3+ adverse events (3.8% vs 13.4%).

Oct 2021, Open Forum Infectious Diseases, https://academic.oup.com/ofid/article/8/Supplement_1/S807/6450927, https://c19p.org/evering

340 patient ambavirumab late treatment study: 71% higher mortality (p=0.35), 8% higher ICU admission (p=0.8), 8% shorter hospitalization (p=0.004), and 7% faster viral clearance (p=0.004).
Retrospective 340 COVID-19 patients in China showing shorter length of hospital stay and faster viral clearance with BRII-196 plus BRII-198 monoclonal antibody treatment, especially when given early. The treatment did not show efficacy for improving clinical outcomes among severe or critical cases.

Apr 2024, BMC Pharmacology and Toxicology, https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-024-00753-7, https://c19p.org/yalan

354 patient ambavirumab late treatment RCT: 15% higher mortality (p=0.72) and 7% improved recovery (p=0.48).
RCT with 182 sotrovimab patients, 176 BRII-196+BRII-198 patients, and 178 control patients, median 8 days from symptom onset, showing no significant differences and terminated early due to futility.

Dec 2021, The Lancet Infectious Diseases, https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00751-9/fulltext, https://c19p.org/self3am
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