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COVID-19 prophylaxis with Doxycycline and Zinc in Health Care Workers: A prospective randomized double-blind clinical tria

Stambouli et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.06.016, NCT04584567
Jun 2022  
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Symp. case 68% Improvement Relative Risk Case 5% Ct values 21% Zinc  Stambouli et al.  Prophylaxis  DB RCT Is prophylaxis with zinc beneficial for COVID-19? Double-blind RCT 115 patients in Tunisia (November 2020 - February 2021) Improved viral load with zinc (p<0.000001) c19early.org Stambouli et al., Int. J. Infectious D.., Jun 2022 Favorszinc Favorscontrol 0 0.5 1 1.5 2+
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now with p = 0.00000064 from 45 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Prophylaxis RCT with 59 zinc + doxycycline, 56 doxycycline, and 57 placebo healthcare workers, showing lower symptomatic cases and significantly improved Ct values with the addition of zinc to doxycycline treatment. Doxycycline 100mg/day and zinc 15 mg/day.
risk of symptomatic case, 68.4% lower, RR 0.32, p = 0.36, treatment 1 of 59 (1.7%), control 3 of 56 (5.4%), NNT 27, zinc + doxycycline vs. doxycycline.
risk of case, 5.1% lower, RR 0.95, p = 1.00, treatment 5 of 59 (8.5%), control 5 of 56 (8.9%), NNT 220, zinc + doxycycline vs. doxycycline.
relative Ct values, 21.4% better, RR 0.79, p < 0.001, treatment mean 29.0 (±1.3) n=59, control mean 22.8 (±4.0) n=56, zinc + doxycycline vs. doxycycline.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Stambouli et al., 17 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, peer-reviewed, 22 authors, study period 12 November, 2020 - 10 February, 2021, trial NCT04584567 (history). Contact: nejlastam@gmail.com.
This PaperZincAll
COVID-19 prophylaxis with doxycycline and zinc in health care workers: a prospective, randomized, double-blind clinical trial
Nejla Stambouli, Adel Driss, Faten Gargouri, Khadija Bahrini, Bilel Arfaoui, Rim Abid, Karima Taamallah, Souha Hannachi, Sana Boughariou, Aicha Rebai, Imen Naas, Mohamed Ghanem, Hassib Ammar, Chiraz Aichaouia, Asma Harrathi, Mohamed Ali Yousfi, Riadh Battikh, Mohamed Ben Moussa, Rabie Razgallah, Mustapha Ferjani, Hédi Gharsallah
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.06.016
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interest statement: The manuscript is an original work that has never been published or is under consideration for publication in another journal. We confirm that all authors have participated in the study and have approved the manuscript. Contributions Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:
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