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Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of Rhinitis in Children

Šlapak et al., Archives of Otolaryngology–Head & Neck Surgery, doi:10.1001/archoto.2007.19, Jan 2008
https://c19early.org/slapak.html
NaCl for COVID-19
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6,100+ studies for 170+ treatments. c19early.org
RCT 401 children aged 6-10, showing significant benefits with isotonic seawater nasal wash for treating and preventing upper respiratory tract infections.
Šlapak et al., 1 Jan 2008, Randomized Controlled Trial, France, peer-reviewed, 4 authors. Contact: jana.skoupa@iol.cz.
Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of Rhinitis in Children
MD Ivo Šlapak, MD Jana Skoupá, MD Petr Strnad, MD Pavel Horník
Objective: To evaluate the potential of nasal isotonic saline application to prevent reappearance of cold and flu in children during the winter.
References
Adam, Stiffman, Blake, A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis, Arch Fam Med
Boek, Keles, Graamans, Huizing, Physiologic and hypertonic saline solution impair ciliary activity in vitro, Laryngoscope
Brown, Graham, Nasal irrigations: good or bad?, Curr Opin Otolaryngol Head Neck Surg
Fokkens, Lund, Bachert, EAACI position paper on rhinosinusitis and nasal polyps, Allergy
Franc ¸aise De Se ´curite ´sanitaire Des Produits De Sante, Systemic antibiotic treatment in upper and lower respiratory tract infections: official French guidelines, Clin Microbiol Infect
Garavello, Romagnoli, Sordo, Gaini, Berardino et al., Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study, Pediatr Allergy Immunol
Halle ´n, Graf, Benzalkonium chloride in nasal decongestive sprays has a longlasting adverse effect on the nasal mucosa of healthy volunteers, Clin Exp Allergy
Heatley, Mcconnell, Kille, Leverson, Nasal irrigation for the alleviation of sinonasal symptoms, Otolaryngol Head Neck Surg
Min, Kim, Suh, Jeon, Son et al., Paranasal sinusitis after long-term use of topical nasal decongestants, Acta Otolaryngol
Nash, Harman, Wald, Kelleher, Antibiotic prescribing by primary care physicians for children with upper respiratory tract infections, Arch Pediatr Adolesc Med
Papsin, Mctavish, Saline nasal irrigation: its role as an adjunct treatment, Can Fam Physician
Shoseyov, Bibi, Shai, Shoseyov, Shazberg et al., Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis, J Allergy Clin Immunol
Tabary, Muselet, Yvin, Halley-Vanhove, Puchelle et al., Physiomer reduces the chemokine interleukin-8 production by activated human respiratory epithelial cells, Eur Respir J
Talbot, Herr, Parsons, Mucociliary clearance and buffered hypertonic saline solution, Laryngoscope
Tano, Tano, A daily nasal spray with saline prevents symptoms of rhinitis, Acta Otolaryngol
Van Cauwenberge, Bachert, Passalacqua, Consensus statement on the treatment of allergic rhinitis, Allergy
Van Cauwenberge, Watelet, Epidemiology of chronic rhinosinusitis, Thorax
Wald, Guerra, Byers, Upper respiratory tract infections in young children: duration of and frequency of complications, Pediatrics
DOI record: { "DOI": "10.1001/archoto.2007.19", "ISSN": [ "0886-4470" ], "URL": "http://dx.doi.org/10.1001/archoto.2007.19", "author": [ { "affiliation": [], "family": "Šlapak", "given": "Ivo", "sequence": "first" }, { "affiliation": [], "family": "Skoupá", "given": "Jana", "sequence": "additional" }, { "affiliation": [], "family": "Strnad", "given": "Petr", "sequence": "additional" }, { "affiliation": [], "family": "Horník", "given": "Pavel", "sequence": "additional" } ], "container-title": "Archives of Otolaryngology–Head & Neck Surgery", "container-title-short": "Arch Otolaryngol Head Neck Surg", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2008, 1, 21 ] ], "date-time": "2008-01-21T21:13:35Z", "timestamp": 1200950015000 }, "deposited": { "date-parts": [ [ 2023, 4, 7 ] ], "date-time": "2023-04-07T23:25:30Z", "timestamp": 1680909930000 }, "indexed": { "date-parts": [ [ 2025, 8, 19 ] ], "date-time": "2025-08-19T11:06:40Z", "timestamp": 1755601600274 }, "is-referenced-by-count": 85, "issue": "1", "issued": { "date-parts": [ [ 2008, 1, 1 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2008, 1, 1 ] ] } }, "language": "en", "link": [ { "URL": "https://archotol.jamanetwork.com/ama/content_public/journal/otol/5638/ooa70134_67_74.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "10", "original-title": [], "page": "67", "prefix": "10.1001", "published": { "date-parts": [ [ 2008, 1, 1 ] ] }, "published-print": { "date-parts": [ [ 2008, 1, 1 ] ] }, "publisher": "American Medical Association (AMA)", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "http://archotol.jamanetwork.com/article.aspx?doi=10.1001/archoto.2007.19" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of Rhinitis in Children", "type": "journal-article", "volume": "134" }
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