What is the role of proton pump inhibitors consumption on the clinical presentation and severity of COVID-19 infection?
M A Shokri, T Moghadam Fard, T Ramim, A Hejrati, L Hejrati, M Mokhtare
Annales Pharmaceutiques Françaises, doi:10.1016/j.pharma.2022.08.013
The COVID-19 severity scores (qCSI) were significantly higher in PPI users compared to non-users, in population with no comorbidity (Charlson Comorbidity Index = 0). • Mortality rate wasn't significantly different between PPI-users and non-users. • All three types of COVID-19 symptoms investigated in this study (flu-like, respiratory and gastrointestinal) manifested more in PPI users than non-users.
Author contribution All authors had access to the data and a role in data gathering and writing the manuscript.
Disclosure of interest The authors declare that they have no competing interest.
References
Almario, Chey, Spiegel, Increased risk of COVID-19 among users of proton pump inhibitors, Am J Gastroenterol
Alzubaidi, Gabbard, GERD: Diagnosing and treating the burn, Cleve Clin J Med
Antunes, Curtis, Gastroesophageal Reflux Disease
Bagherzadeh, Safari, Amanlou, Motevalian, Proton pump inhibitors in Iranian population: from clinical regimens to pharmacogenomics, Physiol Pharmacol
Blanc, Waechter, Vogel, Schorr, Demuynck et al., Therapeutic prevention of COVID-19 in elderly: a case-control study, Geroscience
Blanco, Ambrosioni, Garcia, Martínez, Soriano et al., COVID-19 in patients with HIV: clinical case series, Lancet HIV
Dadras, Afsahi, Pashaei, Mojdeganlou, Karimi et al., The relationship between COVID-19 viral load and disease severity: a systematic review, Immun Inflamm Dis
Domingo, Proton pump inhibitors in the COVID-19 pandemic. Gastroenterología y Hepatología
Fang, Li, Yu, Wang, Zhang et al., Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis, Aging
Gao, Ding, Dong, Zhang, Azkur et al., Risk factors for severe and critically ill COVID-19 patients: a review, Allergy
Grasselli, Greco, Zanella, Albano, Antonelli et al., Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy, JAMA Intern Med
Haimovich, Ravindra, Stoytchev, Young, Wilson et al., Development and validation of the quick COVID-19 Severity Index: a prognostic tool for early clinical decompensation, Ann Emerg Med
Hariyanto, Prasetya, Kurniawan, Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection, Dig Liver Dis
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Hoteit, Mattar, Allaw, Rached, Epidemiological study assessing the overuse of proton pump inhibitors in Lebanese population, Middle East J Dig Dis
Israelsen, Ernst, Lundh, Lundbo, Sandholdt et al., Proton Pump inhibitor use is not strongly associated with SARS-CoV-2 related outcomes: a nationwide study and meta-analysis, Clin Gastroenterol Hepatol
Izcovich, Ragusa, Tortosa, Marzio, Agnoletti et al., Prognostic factors for severity and mortality in patients infected with COVID-19: a systematic review, PLOS ONE
Kellerman, Kintanar, Gastroesophageal reflux disease, Prim Care
Khatami, Saatchi, Zadeh, Aghamir, Shabestari et al., A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis, Sci Rep
Kow, Hasan, Use of proton pump inhibitors and risk of adverse clinical outcomes from COVID-19: a meta-analysis, J Intern Med
Lai, Wang, Wang, Hsueh, Ko et al., Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status, Int J Antimicrob Agents
Lee, Ha, Yeniova, Moon, Kim et al., Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching, Gut
Lighter, Phillips, Hochman, Sterling, Johnson et al., Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission, Clin Infect Dis
Liu, Sloan, Owings, Figgins, Gauthier et al., Increased ACE2 levels and mortality risk of patients with COVID-19 on proton pump inhibitor therapy, Am J Gastroenterol
Mokhtare, Alimoradzadeh, Agah, Mirmiranpour, Khodabandehloo, The Association between modulating inflammatory cytokines and constipation of geriatrics in Iran, Middle East J Dig Dis
Novelli, Biancolella, Mehrian-Shai, Erickson, Pollitt et al., COVID-19 update: the first 6 months of the pandemic, Hum Genomics
Pranata, Huang, Lawrensia, Henrina, Lim et al., Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis, Pharmacol Rep
Quan, Li, Couris, Fushimi, Graham et al., Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries, Am J Epidemiol
Ramachandran, Perisetti, Gajendran, Louis, Bansal et al., Pre-hospitalization proton pump inhibitor use and clinical outcomes in COVID-19, Eur J Gastroenterol Hepatol
Raudenská, Steinerová, Javůrková, Urits, Kaye et al., Occupational burnout syndrome and posttraumatic stress among healthcare professionals during the novel coronavirus disease 2019 (COVID-19) pandemic, Best Pract Res Clin Anaesthesiol
Sung, Kuipers, El-Serag, Systematic review: the global incidence and prevalence of peptic ulcer disease, Aliment Pharmacol Ther
Tas ¸temur S ¸, Ataseven, Is it possible to use proton pump inhibitors in COVID-19 treatment and prophylaxis?, Med Hypotheses
Torres, Valencia, Sellares, PNEUMONIA | Nosocomial
Who, Archived: WHO Timeline -COVID-19
Yan, Chen, Sun, Ahmed, Bhan et al., Does proton pump inhibitor use lead to a higher risk of coronavirus disease 2019 infection and progression to severe disease? A meta-analysis, Jpn J Infect Dis
Yibirin, Oliveira, Valera, Plitt, Lutgen, Adverse effects associated with proton pump inhibitor use, Cureus
Younes, Al-Sadeq, Al-Jighefee, Younes, Daas, Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2, Viruses
Zhang, Kang, Gong, Xu, Wang et al., Digestive system is a potential route of COVID-19: an analysis of singlecell coexpression pattern of key proteins in viral entry process, Gut
Zhang, Li, Wu, Ling, Qian et al., Analysis of the effect of proton-pump inhibitors on the course of COVID-19, J Inflamm Res
Zippi, Fiorino, Budriesi, Micucci, Corazza et al., Paradoxical relationship between proton pump inhibitors and COVID-19: a systematic review and meta-analysis, World J Clin Cases
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'meta-analysis',
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'risk adjustment in hospital discharge abstracts using data from 6 '
'countries',
'volume': '173',
'author': 'Quan',
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'doi-asserted-by': 'crossref',
'first-page': '442',
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'prognostic tool for early clinical decompensation',
'volume': '76',
'author': 'Haimovich',
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'doi-asserted-by': 'crossref',
'first-page': '22402',
'DOI': '10.1038/s41598-020-80061-2',
'article-title': 'A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in '
'COVID-19 diagnosis',
'volume': '10',
'author': 'Khatami',
'year': '2020',
'journal-title': 'Sci Rep'},
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'article-title': 'Adverse effects associated with proton pump inhibitor use',
'volume': '13',
'author': 'Yibirin',
'year': '2021',
'journal-title': 'Cureus'},
{ 'issue': '4',
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'doi-asserted-by': 'crossref',
'first-page': '230',
'DOI': '10.32598/ppj.24.4.40',
'article-title': 'Proton pump inhibitors in Iranian population: from clinical regimens to '
'pharmacogenomics',
'volume': '24',
'author': 'Bagherzadeh',
'year': '2020',
'journal-title': 'Physiol Pharmacol'},
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'doi-asserted-by': 'crossref',
'first-page': '1638',
'DOI': '10.14309/ajg.0000000000001311',
'article-title': 'Increased ACE2 levels and mortality risk of patients with COVID-19 on '
'proton pump inhibitor therapy',
'volume': '116',
'author': 'Liu',
'year': '2021',
'journal-title': 'Am J Gastroenterol'},
{ 'issue': '6',
'key': '10.1016/j.pharma.2022.08.013_bib0340',
'doi-asserted-by': 'crossref',
'first-page': '1642',
'DOI': '10.1007/s43440-021-00263-x',
'article-title': 'Proton pump inhibitor on susceptibility to COVID-19 and its severity: a '
'systematic review and meta-analysis',
'volume': '73',
'author': 'Pranata',
'year': '2021',
'journal-title': 'Pharmacol Rep'},
{ 'issue': '9',
'key': '10.1016/j.pharma.2022.08.013_bib0345',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.cgh.2021.05.011',
'article-title': 'Proton Pump inhibitor use is not strongly associated with SARS-CoV-2 '
'related outcomes: a nationwide study and meta-analysis',
'volume': '19',
'author': 'Israelsen',
'year': '2021',
'journal-title': 'Clin Gastroenterol Hepatol'},
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'article-title': 'Increased risk of COVID-19 among users of proton pump inhibitors',
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'author': 'Almario',
'year': '2020',
'journal-title': 'Am J Gastroenterol'},
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'doi-asserted-by': 'crossref',
'first-page': '1410',
'DOI': '10.1016/j.dld.2020.10.001',
'article-title': 'Proton pump inhibitor use is associated with increased risk of severity '
'and mortality from coronavirus disease 2019 (COVID-19) infection',
'volume': '52',
'author': 'Hariyanto',
'year': '2020',
'journal-title': 'Dig Liver Dis'},
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'doi-asserted-by': 'crossref',
'first-page': '125',
'DOI': '10.1111/joim.13183',
'article-title': 'Use of proton pump inhibitors and risk of adverse clinical outcomes '
'from COVID-19: a meta-analysis',
'volume': '289',
'author': 'Kow',
'year': '2021',
'journal-title': 'J Intern Med'},
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'doi-asserted-by': 'crossref',
'first-page': '287',
'DOI': '10.2147/JIR.S292303',
'article-title': 'Analysis of the effect of proton-pump inhibitors on the course of '
'COVID-19',
'volume': '14',
'author': 'Zhang',
'year': '2021',
'journal-title': 'J Inflamm Res'},
{ 'issue': '12',
'key': '10.1016/j.pharma.2022.08.013_bib0370',
'doi-asserted-by': 'crossref',
'first-page': '2763',
'DOI': '10.12998/wjcc.v9.i12.2763',
'article-title': 'Paradoxical relationship between proton pump inhibitors and COVID-19: a '
'systematic review and meta-analysis',
'volume': '9',
'author': 'Zippi',
'year': '2021',
'journal-title': 'World J Clin Cases'},
{ 'key': '10.1016/j.pharma.2022.08.013_bib0375',
'series-title': 'Encyclopedia of Respiratory Medicine',
'article-title': 'PNEUMONIA\xa0|\xa0Nosocomial',
'author': 'Torres',
'year': '2006'},
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'doi-asserted-by': 'crossref',
'first-page': '1010',
'DOI': '10.1136/gutjnl-2020-320953',
'article-title': 'Digestive system is a potential route of COVID-19: an analysis of '
'single-cell coexpression pattern of key proteins in viral entry process',
'volume': '69',
'author': 'Zhang',
'year': '2020',
'journal-title': 'Gut'},
{ 'issue': '2',
'key': '10.1016/j.pharma.2022.08.013_bib0385',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.cell.2020.02.052',
'article-title': 'SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a '
'clinically proven protease inhibitor',
'volume': '181',
'author': 'Hoffmann',
'year': '2020',
'journal-title': 'Cell'},
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'first-page': 'e580',
'DOI': '10.1002/iid3.580',
'article-title': 'The relationship between COVID-19 viral load and disease severity: a '
'systematic review',
'volume': '10',
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