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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Symptoms decrease ≥30% 81% Improvement Relative Risk Symptoms decrease ≥70% 58% Symptoms decrease ≥90% 36% Radiographic improvement 1% Viral clearance -8% Quercetin  Shah et al.  EARLY TREATMENT  DB RCT Is early treatment with quercetin beneficial for COVID-19? Double-blind RCT 300 patients in Pakistan (September 2020 - August 2021) Greater improvement with quercetin (p<0.000001) c19early.org Shah et al., medRxiv, May 2022 Favors quercetin Favors control

Jinhua Qinggan Granules for Nonhospitalized COVID-19 Patients: a Double-Blind, Placebo-Controlled, Randomized Controlled Trial

May 2022  
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Quercetin for COVID-19
22nd treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
RCT 300 outpatients in China, showing improved recovery with Jinhua Qinggan treatment, but no significant difference in viral clearance or radiographic findings. Jinhua Qinggan includes quercetin, rutin, luteolin, wogonin, myricetin, ursolic acid, chrysoeriol, glabridin, stigmasterol, and kaempferol.
This study is excluded in meta analysis: combination of several ingredients with unclear dosage.
risk of no symptoms decrease ≥30%, 80.6% lower, RR 0.19, p < 0.001, treatment 26 of 150 (17.3%), control 134 of 150 (89.3%), NNT 1.4.
risk of no symptoms decrease ≥70%, 58.1% lower, RR 0.42, p < 0.001, treatment 62 of 150 (41.3%), control 148 of 150 (98.7%), NNT 1.7.
risk of no symptoms decrease ≥90%, 35.8% lower, RR 0.64, p < 0.001, treatment 95 of 150 (63.3%), control 148 of 150 (98.7%), NNT 2.8.
risk of no radiographic improvement, 0.7% lower, RR 0.99, p = 1.00, treatment 112 of 128 (87.5%), control 111 of 126 (88.1%), NNT 168.
risk of no viral clearance, 8.1% higher, RR 1.08, p = 0.48, treatment 93 of 150 (62.0%), control 86 of 150 (57.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shah et al., 20 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Pakistan, preprint, 10 authors, study period 22 September, 2020 - 23 August, 2021, trial NCT04723524 (history). Contact: raza.shah@iccs.edu, liuqingquan@bjzhongyi.com, dennislam@hkcmer.com.
This PaperQuercetinAll
Jinhua Qinggan Granules for Nonhospitalized COVID-19 Patients: a Double-Blind, Placebo-Controlled, Randomized Controlled Trial
Muhammad Raza Shah, Samreen Fatima, Sehrosh Naz Khan, Shafiullah, Gulshan Himani, Kelvin Wan, Timothy Lin, Johnson Y N Lau, Qingquan Liu, Dennis S C Lam
doi:10.1101/2022.05.16.22275074
Background: Key findings from the World Health Organization Expert Meeting on Evaluation of Traditional Chinese Medicine in treating COVID-19 reported that TCMs are beneficial, particularly for mild-to-moderate cases. The efficacy of Jinhua Qinggan Granules (JHQG) in COVID-19 patients with mild symptoms has yet to be clearly defined. Methods: We conducted a phase 2/3, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of treatment with JHQG in mild, nonhospitalized, laboratoryconfirmed COVID-19 patients. Participants were randomly assigned to receive 5g/sacket of JHQG or placebo granules orally thrice daily for 10 days. The primary outcomes were the improvement in clinical symptoms and proportion tested negative on viral PCR after treatment. Secondary outcomes were the time to recovery from clinical symptoms and changes in white blood cells (WBC) and acute phase reactants (C-reactive protein (CRP) and ferritin) 10-15 days after treatment. Results: A total of 300 patients were randomly assigned to receive JHQG (150 patients) and placebo (150 patients). Baseline characteristics were similar in the two groups. In the modified intention-to-treat analysis, JHQG showed greater clinical efficacy (82.67%) after 10 days of treatment compared with the placebo group (10.74%) (rate difference: 71.93%; 95% CI 64.09 -79.76). The proportion of patients with a negative PCR after treatment were comparable (rate difference: -4.67%; 95% . While all changes in WBC, ferritin, and CRP levels showed a statistically significant decline in JHQG (P≤0.044) after treatment, but not the latter in placebo (P=0.077). The median time to recovery of COVID-19 related symptoms including cough, sputum, sore throat, dyspnea, headache, nasal obstruction, fatigue, and myalgia were shorter in the JHQG group compared to the placebo group (P<0.001 for all). 3 patients experienced mild to moderate adverse events during the treatment period in the JHQG group. Findings were similar between the modified intention-to-treat and the per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen. Conclusions: JHQG is a safe and effective TCM for the treatment of mild COVID-19 patients.
To our knowledge, this is the first RCT to evaluate the clinical efficacy and safety of JHQG in the treatment of laboratory-confirmed nonhospitalized COVID-19 patients. Various limitations of this trial should be noted. The basic reason for dropout was that the subjects were unable or unwilling to continue the clinical trial and voluntarily requested to withdraw The study included only COVID-19 patients of Pakistani race, and may limit the geographic generalizability of the findings. This study also excluded patients with severe underlying medical conditions, who are at particularly heightened risk of COVID-19 disease progression. Future studies of JHQG in COVID-19 shall focus on evaluating the clinical efficacy and safety of this TCM in such group of patients. In conclusion, our data show that JHQG is a safe and effective treatment for COVID-19 patients with mild symptoms. Conflict of interests The authors declare that they have no conflict of interests. Ethical Statement This study was conducted according to the ethical principles that have their origin in Declaration of Helsinki. The study protocol was reviewed and approved by the Institutional ethics committee
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