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All Studies   Meta Analysis    Recent:   

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

Qian et al., Acta Pharmacologica Sinica, doi:10.1038/s41401-022-00895-6, NCT05242042
Mar 2022  
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Phase 1 study of the safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog prodrug, in healthy subjects. A single ascending dose study, multiple ascending dose study, and food effect study were conducted sequentially in 86 subjects. VV116 exhibited dose-proportional pharmacokinetics up to 800mg and slight accumulation upon multiple twice daily dosing. Food intake prolonged time to peak levels but did not affect overall exposure.
Qian et al., 16 Mar 2022, placebo-controlled, China, peer-reviewed, 21 authors, study period November 2021 - January 2022, trial NCT05242042 (history). Contact: zhangwenhong@fudan.edu.cn, wangzhen@lglab.ac.cn, gyliu@shxh-centerlab.com.
This PaperDeuremidevirAll
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
Hong-Jie Qian, Yu Wang, Meng-Qi Zhang, Yuan-Chao Xie, Qing-Qing Wu, Li-Yu Liang, Ye Cao, Hua-Qing Duan, Guang-Hui Tian, Juan Ma, Zhuo-Bing Zhang, Ning Li, Jing-Ying Jia, Jing Zhang, Haji Akber Aisa, Jing-Shan Shen, Chen Yu, Hua-Liang Jiang, Wen-Hong Zhang, Zhen Wang, Gang-Yi Liu
Acta Pharmacologica Sinica, doi:10.1038/s41401-022-00895-6
VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects, as well as the effect of food on the pharmacokinetics and safety of VV116. Three studies were launched sequentially: Study 1 (single ascending-dose study, SAD), Study 2 (multiple ascending-dose study, MAD), and Study 3 (food-effect study, FE). A total of 86 healthy subjects were enrolled in the studies. VV116 tablets or placebo were administered per protocol requirements. Blood samples were collected at the scheduled time points for pharmacokinetic analysis. 116-N1, the metabolite of VV116, was detected in plasma and calculated for the PK parameters. In SAD, AUC and C max increased in an approximately dose-proportional manner in the dose range of 25-800 mg. T 1/2 was within 4.80-6.95 h. In MAD, the accumulation ratio for C max and AUC indicated a slight accumulation upon repeated dosing of VV116. In FE, the standard meal had no effect on C max and AUC of VV116. No serious adverse event occurred in the studies, and no subject withdrew from the studies due to adverse events. Thus, VV116 exhibited satisfactory safety and tolerability in healthy subjects, which supports the continued investigation of VV116 in patients with COVID-19.
AUTHOR CONTRIBUTIONS All authors contributed to the studies and manuscript. GYL, ZW, WHZ, HLJ, CY, JSS, HAA, JZ, JYJ, HJQ, HQD, and GHT designed and supervised the study; HJQ, GYL, CY, JYJ, QQW, MQZ and LYL performed and executed the study; YW, ZW, JM, YCX, ZBZ, and NL analyzed and interpreted the data; HJQ, QQW, LYL, YCX, and YC wrote the initial draft; all authors critically reviewed or revised the draft of the manuscript, and approved the final manuscript. ADDITIONAL INFORMATION Competing interests: HQD and GHT are the employees of Vigonvita Life Science Co., Ltd, the sponsor of the study. JM, ZBZ, and NL are the employees of Shanghai Junshi Biosciences Co., Ltd., the parent company of the co-sponsor Shanghai JunTop Biosciences Co., Ltd. YCX, JSS, and HLJ filed a patent application on antiviral nucleoside analogs. The remaining authors declare no competing interests.
References
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Yates, Seley-Radtke, The evolution of antiviral nucleoside analogues: a review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold, Antivir Res
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