Vitamin D receptor gene polymorphisms role in COVID‐19 severity: Results of a Mexican patients’ cohort

{ 'indexed': {'date-parts': [[2024, 4, 30]], 'date-time': '2024-04-30T00:30:37Z', 'timestamp': 1714437037969}, 'reference-count': 22, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2024, 4, 28]], 'date-time': '2024-04-28T00:00:00Z', 'timestamp': 1714262400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Vitamin D status has been involved with coronavirus ' 'disease 19 (COVID‐19) severity. This may be mediated by vitamin D metabolism regulatory ' 'genes. Of interest is the vitamin D receptor (VDR) gene, which has been previously associated ' 'with other inflammatory and respiratory diseases. In order to investigate the role of VDR ' 'gene polymorphisms in COVID‐19 severity and outcome, a total of 292 COVID‐19 patients were ' 'classified according to severity in moderate (<jats:italic>n</jats:italic>\xa0=\xa056), ' 'severe (<jats:italic>n</jats:italic>\xa0=\xa089) and critical ' '(<jats:italic>n</jats:italic>\xa0=\xa0147) and, according to outcome in survivor ' '(<jats:italic>n</jats:italic>\xa0=\xa0163) and deceased (<jats:italic>n</jats:italic>\xa0=\xa0' '129), and analysed for <jats:italic>Fok</jats:italic>I and <jats:italic>Taq</jats:italic>I ' 'VDR gene polymorphisms by polymerase chain reaction‐based restriction enzyme digestion. The ' '<jats:italic>Fok</jats:italic>I and <jats:italic>Taq</jats:italic>I single nucleotide ' 'polymorphisms (SNPs) were not associated with COVID‐19 severity or mortality individually but ' 'when analysed by haplotype, TC was associated with an increased risk of presenting critical ' 'COVID‐19. Additionally, <jats:italic>Fok</jats:italic>I CT genotype was more frequent in ' 'COVID‐19 patients with hypertension, and T allele carriers presented higher aspartate ' 'aminotransferase levels. Our results suggest a relationship between VDR ' '<jats:italic>Fok</jats:italic>I and <jats:italic>Taq</jats:italic>I SNPs and COVID‐19 ' 'severity in Mexican population. Although there are some previous reports of VDR polymorphisms ' 'in COVID‐19, this represents the first report in Latin American population. Further studies ' 'on other populations are encouraged.</jats:p>', 'DOI': '10.1111/iji.12674', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 29]], 'date-time': '2024-04-29T04:04:25Z', 'timestamp': 1714363465000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Vitamin D receptor gene polymorphisms role in COVID‐19 severity: Results of a Mexican patients’ ' 'cohort', 'prefix': '10.1111', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-5912-6500', 'authenticated-orcid': False, 'given': 'Luis Antonio', 'family': 'Ochoa‐Ramírez', 'sequence': 'first', 'affiliation': [ { 'name': 'Hospital General de Culiacán, Servicios de Salud de Sinaloa ' 'Culiacan Mexico'}]}, { 'given': 'Alba Lissy', 'family': 'Corona‐Angulo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Maestría en Ciencias Biomédicas, Facultad de Ciencias Químico ' 'Biológicas Culiacan Mexico'}]}, { 'given': 'Efrén Rafael', 'family': 'Ríos‐Burgueño', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital General de Culiacán, Servicios de Salud de Sinaloa ' 'Culiacan Mexico'}, { 'name': 'Centro de Investigación y Docencia en Ciencias de la Salud ' 'Culiacan Mexico'}]}, { 'given': 'Jorge Guillermo', 'family': 'Sánchez‐Zazueta', 'sequence': 'additional', 'affiliation': [ { 'name': 'Facultad de Biología Universidad Autónoma de Sinaloa Culiacán ' 'Sinaloa Mexico'}]}, { 'ORCID': 'http://orcid.org/0000-0003-1251-3383', 'authenticated-orcid': False, 'given': 'Denisse Stephania', 'family': 'Becerra‐Loaiza', 'sequence': 'additional', 'affiliation': [ { 'name': 'Departamento de Aparatos y Sistemas II Universidad Autónoma de ' 'Guadalajara Zapopan Jalisco México'}]}, { 'given': 'Jesús Salvador', 'family': 'Velarde‐Félix', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital General de Culiacán, Servicios de Salud de Sinaloa ' 'Culiacan Mexico'}, { 'name': 'Maestría en Ciencias Biomédicas, Facultad de Ciencias Químico ' 'Biológicas Culiacan Mexico'}, { 'name': 'Facultad de Biología Universidad Autónoma de Sinaloa Culiacán ' 'Sinaloa Mexico'}]}], 'member': '311', 'published-online': {'date-parts': [[2024, 4, 28]]}, 'reference': [ { 'key': 'e_1_2_9_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.meegid.2021.105098'}, {'key': 'e_1_2_9_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/genes13122346'}, {'key': 'e_1_2_9_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/cen.14664'}, { 'key': 'e_1_2_9_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/biomedicines11020400'}, {'key': 'e_1_2_9_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41584‐023‐00944‐2'}, {'key': 'e_1_2_9_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1210/clinem/dgab892'}, {'key': 'e_1_2_9_8_1', 'doi-asserted-by': 'publisher', 'DOI': '10.17179/excli2022‐4976'}, {'key': 'e_1_2_9_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmjopen‐2022‐064058'}, {'key': 'e_1_2_9_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3892/etm.2023.11920'}, {'key': 'e_1_2_9_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fnut.2021.689419'}, { 'key': 'e_1_2_9_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/j.1365‐2133.2012.11132.x'}, {'key': 'e_1_2_9_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ppul.22877'}, { 'key': 'e_1_2_9_14_1', 'unstructured': 'Mexico Government. (2021).Reporte de vigilancia genómica del virus ' 'SARS‐CoV‐2 en México.Mexico ' 'Government.https://coronavirus.gob.mx/wp‐content/uploads/2021/09/2021.08.30_ReporteVariantesCOVID‐2.pdf'}, {'key': 'e_1_2_9_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/advances/nmaa076'}, {'key': 'e_1_2_9_16_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/ijd.14508'}, { 'key': 'e_1_2_9_17_1', 'doi-asserted-by': 'publisher', 'DOI': '10.22034/iji.2022.92641.2162'}, {'key': 'e_1_2_9_18_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/ijms21249626'}, {'key': 'e_1_2_9_19_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bcmd.2013.02.001'}, { 'key': 'e_1_2_9_20_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.arcmed.2023.03.006'}, { 'key': 'e_1_2_9_21_1', 'volume-title': 'Living guidance for clinical management of COVID‐19', 'author': 'World Health Organization (WHO)', 'year': '2021'}, {'key': 'e_1_2_9_22_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s12016‐022‐08921‐5'}, { 'key': 'e_1_2_9_23_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/08820139.2019.1674325'}], 'container-title': 'International Journal of Immunogenetics', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/iji.12674', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 29]], 'date-time': '2024-04-29T04:04:32Z', 'timestamp': 1714363472000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/iji.12674'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4, 28]]}, 'references-count': 22, 'alternative-id': ['10.1111/iji.12674'], 'URL': 'http://dx.doi.org/10.1111/iji.12674', 'relation': {}, 'ISSN': ['1744-3121', '1744-313X'], 'subject': [], 'container-title-short': 'Int J Immunogenetics', 'published': {'date-parts': [[2024, 4, 28]]}, 'assertion': [ { 'value': '2023-10-18', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-04-14', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-04-28', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}