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All Studies   Meta Analysis    Recent:   

Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients

Noce et al., Pharmaceuticals, doi:10.3390/ph17040463
Apr 2024  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
RCT of 33 long COVID outpatients showing anti-inflammatory and anti-fatigue effects with treatment based on Echinacea angustifolia, rosehip, propolis, royal jelly, and zinc. The treatment significantly reduced inflammatory biomarkers like CRP, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio compared to placebo. It also significantly increased vitamin D levels. Patients reported improved quality of life and reduced fatigue.
Study covers propolis and zinc.
Noce et al., 5 Apr 2024, Double Blind Randomized Controlled Trial, placebo-controlled, Italy, peer-reviewed, 10 authors. Contact: annalisa.noce@uniroma2.it (corresponding author), dilauromanuela@gmail.com, giulia.marrone@uniroma2.it.
This PaperZincAll
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients
Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Chiara Vita, Giulia Montalto, Gloria Giorgino, Carlo Chiaramonte, Cartesio D’agostini, Sergio Bernardini, Massimo Pieri
Pharmaceuticals, doi:10.3390/ph17040463
Long coronavirus disease (COVID) syndrome leads to chronic inflammatory state onset that can have a multisystem impact and compromise organ function. Moreover, long COVID syndrome is often characterized by the presence of chronic fatigue, which affects subjects' daily activities and worsens their quality of life. The aim of our double-blind, placebo-controlled randomized trial (protocol code RS 150.21, approved on 4 November 2021) was to evaluate the beneficial effects of the consumption of 2 cps/day, for two months, of an oral food supplement (OFS), based on Echinacea angustifolia, rosehip, propolis, royal jelly and zinc, in long COVID patients, compared to a two-month placebo period. The OFS's vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS's total polyphenol content was 43.98 mg/g gallic acid equivalents. At the end of the in vivo study, we highlighted a significant decrease in the inflammatory parameters in the OFS period, compared to the placebo period (neutrophil-to-lymphocyte ratio, p = 0.0455; monocyte to-lymphocyte ratio, p = 0.0005; C-reactive protein, p = 0.0145). Our study also highlighted a significant increase in vitamin D serum values (p = 0.0005) and, at the same time, an improvement in patients' life quality and a reduction in fatigue, monitored by the fatigue severity scale. This study showed the OFS's beneficial effects on the inflammatory state, fatigue and quality of life in long COVID patients.
Conflicts of Interest: The authors declare no conflicts of interest. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflicts of interest.
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Late treatment
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