Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
et al., Science Advances, doi:10.1126/sciadv.abi6110 (date from earlier preprint)
, Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune.., Science Advances, doi:10.1126/sciadv.abi6110 (date from earlier preprint)
Retrospective 1,212 patients in the USA with a history of seizure-related conditions, showing patients treated with CBD100 had significantly lower incidence of COVID-19 cases compared to a matched control group.In Vitro study showing CBD inhibits SARS-CoV-2 with Vero E6 and Calu-3 cells. Mouse study showing CBD significantly inhibited viral replication in the lung and nasal turbinate.Authors note that CBD does not inhibit ACE2 expression or the main viral proteases, inhibition occurs after viral entry. Authors stress several limitations for use at this time, including purity, quality, and the formulation of products, and potential lung damage based on administration method.Authors recommend clinical trials, but do not mention the existing RCT by Crippa et al.
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risk of case, 49.6% lower, RR 0.50, p = 0.006, treatment 26 of 531 (4.9%), control 48 of 531 (9.0%), NNT 24, odds ratio converted to relative risk, active CBD100 users.
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risk of case, 32.9% lower, RR 0.67, p = 0.009, treatment 75 of 1,212 (6.2%), control 108 of 1,212 (8.9%), NNT 37, odds ratio converted to relative risk, all CBD100 users.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Nguyen et al., 20 Jan 2022, retrospective, USA, peer-reviewed, 34 authors.
Abstract: SCIENCE ADVANCES | RESEARCH ARTICLE
CORONAVIRUS
Cannabidiol inhibits SARS-CoV-2 replication
through induction of the host ER stress and
innate immune responses
Long Chi Nguyen1§, Dongbo Yang1§, Vlad Nicolaescu2,10§, Thomas J. Best3§, Haley Gula2,10,
Divyasha Saxena4, Jon D. Gabbard4, Shao-Nong Chen5, Takashi Ohtsuki5†, John Brent Friesen5,
Nir Drayman6, Adil Mohamed6, Christopher Dann1, Diane Silva7, Lydia Robinson-Mailman1,
Andrea Valdespino1, Letícia Stock1, Eva Suárez1, Krysten A. Jones8, Saara-Anne Azizi8,
Jennifer K. Demarco4, William E. Severson4, Charles D. Anderson4, James Michael Millis9,
Bryan C. Dickinson8, Savaş Tay6, Scott A. Oakes7, Guido F. Pauli5, Kenneth E. Palmer4,
The National COVID Cohort Collaborative Consortium‡, David O. Meltzer3,
Glenn Randall2,10*, Marsha Rich Rosner1*
Copyright © 2022
The Authors, some
rights reserved;
exclusive licensee
American Association
for the Advancement
of Science. No claim to
original U.S. Government
Works. Distributed
under a Creative
Commons Attribution
NonCommercial
License 4.0 (CC BY-NC).
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we
report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD,
but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells.
CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene
transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1 RNase endoplasmic
reticulum (ER) stress response and interferon signaling pathways. In matched groups of human patients from the
National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative
association with positive SARS-CoV-2 tests. This study highlights CBD as a potential preventative agent for
early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time.
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