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Major trace elements and their binding proteins in the early phase of Covid-19 infection

Nedić et al., JBIC Journal of Biological Inorganic Chemistry, doi:10.1007/s00775-022-01931-w
Feb 2022  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020, now with p = 0.00000032 from 46 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Analysis of 60 COVID-19 patients and 60 matched controls, showing higher zinc levels in COVID-19 patients. The concentration of zinc was close to the lower reference limit in healthy people, and above the reference limit in 20 out of 60 COVID-19 patients. Authors note the increase for COVID-19 patients may be due to the use of zinc supplementation or cellular redistribution of zinc ions.
Nedić et al., 12 Feb 2022, USA, peer-reviewed, 6 authors. Contact: olgica@inep.co.rs.
This PaperZincAll
Major trace elements and their binding proteins in the early phase of Covid-19 infection
Olgica Nedić, Miloš Šunderić, Dragana Robajac, Goran Miljuš, Danilo Četić, Ana Penezić
JBIC Journal of Biological Inorganic Chemistry, doi:10.1007/s00775-022-01931-w
Metal ions seem to play important roles in the pathogenesis of the novel coronavirus disease of 2019 and are under investigation as potential prognostic markers and supplements in therapeutic procedures. The present study was aimed at assessing the relationship between the most abundant essential microelements (iron, zinc and copper) and their major binding proteins in the circulation in the early stage of infection. The concentration of zinc ions was measured to be higher in infected than in healthy persons, as well as ratios zinc/albumin and zinc/alpha-2-macroglobulin. Increased zinc levels could be attributed to cellular redistribution of zinc ions or to a use of zinc supplementation (zinc concentration was above the upper reference limit in one-third of infected individuals). Immunoblot analysis of protein molecular forms revealed that infected persons had greater amounts of proteinase-bound alpha-2-macroglobulin tetramer and albumin monomer than healthy individuals. The quantities of these forms were correlated with the concentration of zinc ions (r = 0.42 and 0.55, respectively) in healthy persons, but correlations were lost in infected individuals, most likely due to very high zinc concentrations in some participants which were not proportionally followed by changes in the distribution of protein species. Although we still have to wait for a firm confirmation of the involvement of zinc in beneficial defense mechanisms in patients with Covid-19, it seems that this ion may contribute to the existence of circulating protein forms which are the most optimal.
Declarations Conflict of interest There are no conflicts or competing interests to declare. Ethical approval Approval no. 02-286/4. Consent to participate Oral informed consent was obtained from participants regarding the use of their blood leftovers for the research purpose. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Ali, Fariha, Islam, Assessment of the role of zinc in the prevention of COVID-19 infections and mortality: A retrospective study in the Asian and European population, J Med Virol
Aljadani, Impact of different dietary patterns and micronutrients on the immune system and COVID-19 infection, Curr Res Nutr Food Sci
Barrett, Brown, Sayers, The electrophoretically "slow" and "fast" forms of the α 2 -macroglobulin molecule, Biochem J
Biamonte, Botta, Mazzitelli, Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility, J Transl Med
Carota, Ronsisvalle, Panarello, Role of iron chelation and protease inhibition of natural products on COVID-19 infection, J Clin Med
Cater, Wilson, Wyatt, Alpha-2-macroglobulin, a hypochlorite-regulated chaperone and immune system modulator, Oxid Med Cell Longev
Catera, Kumitac, Abdallaha, Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia-and Alzheimer's associated amyloid beta peptide, PNAS
Coverdale, Barnett, Adamu, A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution, Metallomics
Doboszewska, Wlaź, Nowak, Targeting zinc metalloenzymes in coronavirus disease 2019, Br J Pharmacol
Domingo, Marques, The effects of some essential and toxic metals/metalloids in COVID-19: A review, Food Chem Toxicol
Dursun, Aydogan, Comparative effects of calcium deficiency and supplements on the intestinal absorption of zinc in rats, Jpn J Physiol
Elham, Azam, Azam, Serum vitamin D, calcium, and zinc levels in patients with COVID-19, Clin Nutr ESPEN
Fooladi, Matin, Mahmoodpoor, Copper as a potential adjunct therapy for critically ill COVID-19 patients, Clin Nutr ESPEN
Fukada, Yamasaki, Nishida, Zinc homeostasis and signaling in health and diseases. Zinc signaling, J Biol Inorg Chem
Gammoh, Rink, Zinc in Infection and Inflammation, Nutrients
Hackler, Heller, Sun, Relation of serum copper status to survival in COVID-19, Nutrients
Heller, Sun, Hackler, Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker, Redox Biol
King, Yet again, serum zinc concentrations are unrelated to zinc intakes, J Nutr
Kumar, Kubota, Chernov, Potential role of zinc supplementation in prophylaxis and treatment of COVID-19, Med Hypotheses
Lillis, Van Duyn, Je, LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies, Physiol Rev
Lv, Chen, Liang, Association between iron status and the risk of adverse outcomes in COVID-19, Clin Nutr ESPEN
Manley, Byrns, Lyon, Simultaneous Cu-, Fe-, and Zn-specific detection of metalloproteins contained in rabbit plasma by size-exclusion chromatography-inductively coupled plasma atomic emission spectroscopy, J Biol Inorg Chem
Mayor-Ibarguren, Busca-Arenzana, Robles-Marhuenda, A hypothesis for the possible role of zinc in the immunological pathways related to COVID-19 infection, Front Immunol
Mocchegiani, Costarelli, Giacconi, Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence, Exp Gerontol
Mondal, Manna, Barik, Zinc and copper homeostasis is crucial to maintain the cellular health and their role in viral diseases including COVID-19, J Indian Chem Soc
Nuttall, Oteiza, Zinc and the aging brain, Genes Nutr
Penezić, Aćimović, Pavićević, The interplay between copper(II), human serum albumin, fatty acids, and carbonylating agent interferes with Cys 34 thiol reactivity and copper binding, J Biol Inorg Chem
Pincemail, Cavalier, Charlier, Oxidative stress status in COVID-19 patients hospitalized in intensive care unit for severe pneumonia. A pilot study, Antioxidants
Sand, Folkersen, Westergaard, Characterization of human pregnancy zone protein. Comparison with human α 2 -macroglobulin, J Biol Chem
Sarcione, Biddle, Elevated serum pregnancy zone protein levels in HIV-1-infected men, AIDS
Skalny, Timashev, Aschner, Serum zinc, copper, and other biometals are associated with COVID-19 severity markers, Metabolites
Sonnweber, Boehm, Sahanic, Persisting alterations of iron homeostasis in COVID19 are associated with nonresolving lung pathologies and poor patients' performance: a prospective observational cohort study, Respir Res
Tian, Zhang, Immune suppression in the early stage of COVID-19 disease, Nature Commun
Vogel-González, Talló-Parra, Herrera-Fernández, Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection, Nutrients
Yang, Lai, SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?, Cell Death Disc
Yağcı, Serin, Acicbe, The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19, Int J Lab Hematol, doi:10.1111/ijlh.13479
Yoshino, Fujimoto, Takada, Molecular form and concentration of serum α2-macroglobulin in diabetes, Sci Rep
Zarzur, Aldao, Sileoni, Serum pregnancyassociated α2-glycoprotein levels in the evolution of hepatitis B virus infection, J Clin Lab Anal
Zeng, Yang, Yuan, Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19, FASEB J
Zhu, Zhang, A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med
Šunderić, Mihailović, Nedić, Protein molecular forms of the insulin-like growth factor binding protein 2 change with ageing, Exp Gerontol
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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