Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a double-blinded randomized clinical trial (LF-COVID)

{ 'indexed': {'date-parts': [[2022, 12, 8]], 'date-time': '2022-12-08T15:13:48Z', 'timestamp': 1670512428615}, 'reference-count': 25, 'publisher': 'Springer Science and Business Media LLC', 'license': [ { 'start': { 'date-parts': [[2022, 12, 7]], 'date-time': '2022-12-07T00:00:00Z', 'timestamp': 1670371200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}, { 'start': { 'date-parts': [[2022, 12, 7]], 'date-time': '2022-12-07T00:00:00Z', 'timestamp': 1670371200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}], 'funder': [ { 'DOI': '10.13039/501100009583', 'name': 'Morinaga Foundation For Health and Nutrition', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'DOI': '10.1007/s10534-022-00477-3', 'type': 'journal-article', 'created': {'date-parts': [[2022, 12, 7]], 'date-time': '2022-12-07T02:02:51Z', 'timestamp': 1670378571000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a ' 'double-blinded randomized clinical trial (LF-COVID)', 'prefix': '10.1007', 'clinical-trial-number': [ { 'clinical-trial-number': 'nct04526821', 'registry': '10.18810/clinical-trials-gov'}], 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-6099-7509', 'authenticated-orcid': False, 'given': 'Rafaella', 'family': 'Navarro', 'sequence': 'first', 'affiliation': []}, {'given': 'Jose Luis', 'family': 'Paredes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lourdes', 'family': 'Tucto', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carlos', 'family': 'Medina', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eddie', 'family': 'Angles-Yanqui', 'sequence': 'additional', 'affiliation': []}, {'given': 'Juan Carlos', 'family': 'Nario', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jorge', 'family': 'Ruiz-Cabrejos', 'sequence': 'additional', 'affiliation': []}, {'given': 'Juan Luis', 'family': 'Quintana', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kevin', 'family': 'Turpo-Espinoza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fernando', 'family': 'Mejia-Cordero', 'sequence': 'additional', 'affiliation': []}, {'given': 'Meylin', 'family': 'Aphang-Lam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jorge', 'family': 'Florez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gabriel', 'family': 'Carrasco-Escobar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Theresa Jean', 'family': 'Ochoa', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 12, 7]]}, 'reference': [ { 'issue': '2', 'key': '477_CR1', 'doi-asserted-by': 'publisher', 'first-page': '209', 'DOI': '10.1111/j.1574-6968.1996.tb08579.x', 'volume': '145', 'author': 'KR Alugupalli', 'year': '1996', 'unstructured': 'Alugupalli KR, Kalfas S (1996) Degradation of lactoferrin by ' 'periodontitis-associated bacteria. FEMS Microbiol Lett 145(2):209–214. ' 'https://doi.org/10.1111/j.1574-6968.1996.tb08579.x', 'journal-title': 'FEMS Microbiol Lett'}, { 'issue': '3', 'key': '477_CR2', 'doi-asserted-by': 'publisher', 'first-page': '197', 'DOI': '10.1016/j.antiviral.2004.05.002', 'volume': '63', 'author': 'L Beljaars', 'year': '2004', 'unstructured': 'Beljaars L, Van Der Strate BWA, Bakker HI, Reker-Smit C, Van ' 'Loenen-Weemaes AM, Wiegmans FC et al (2004) Inhibition of ' 'cytomegalovirus infection by lactoferrin in vitro and in vivo. Antivir ' 'Res 63(3):197–208', 'journal-title': 'Antivir Res'}, { 'key': '477_CR3', 'doi-asserted-by': 'publisher', 'first-page': '351', 'DOI': '10.1139/o06-039', 'volume': '84', 'author': 'F Berlutti', 'year': '2006', 'unstructured': 'Berlutti F, Schippa S, Morea C, Sarli S, Perfetto B, Donnarumma G et al ' '(2006) Lactoferrin downregulates pro-inflammatory cytokines upexpressed ' 'in intestinal epithelial cells infected with invasive or noninvasive ' 'Escherichia coli strains. Biochem Cell Biol 84:351–7', 'journal-title': 'Biochem Cell Biol'}, { 'key': '477_CR4', 'doi-asserted-by': 'publisher', 'author': 'BS Berthon', 'year': '2022', 'unstructured': 'Berthon BS, Williams LM, Williams EJ, Wood LG (2022) Effect of ' 'lactoferrin supplementation on inflammation, immune function, and ' 'prevention of respiratory tract infections in humans: a systematic ' 'review and meta-analysis. Adv Nutr. ' 'https://doi.org/10.1093/advances/nmac047', 'journal-title': 'Adv Nutr', 'DOI': '10.1093/advances/nmac047'}, { 'issue': '3', 'key': '477_CR5', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijantimicag.2020.106118', 'volume': '56', 'author': 'R Chang', 'year': '2020', 'unstructured': 'Chang R, Ng TB, Sun WZ (2020) Lactoferrin as potential preventative and ' 'adjunct treatment for COVID-19. Int J Antimicrob Agents 56(3):106118', 'journal-title': 'Int J Antimicrob Agents'}, { 'issue': '2', 'key': '477_CR6', 'doi-asserted-by': 'publisher', 'first-page': '222', 'DOI': '10.1016/j.nut.2015.08.010', 'volume': '32', 'author': 'K Chen', 'year': '2016', 'unstructured': 'Chen K, Chai L, Li H, Zhang Y, Xie HM, Shang J et al (2016) Effect of ' 'bovine lactoferrin from iron-fortified formulas on diarrhea and ' 'respiratory tract infections of weaned infants in a randomized ' 'controlled trial. Nutrition 32(2):222–227', 'journal-title': 'Nutrition'}, { 'key': '477_CR7', 'unstructured': 'COVID-19 Map—Johns Hopkins Coronavirus Resource Center. ' 'https://coronavirus.jhu.edu/map.html. Accessed 2 May 2021'}, { 'issue': '4', 'key': '477_CR8', 'doi-asserted-by': 'publisher', 'first-page': '495', 'DOI': '10.1002/jmv.10337', 'volume': '69', 'author': 'AM Di Biase', 'year': '2003', 'unstructured': 'Di Biase AM, Pietrantoni A, Tinari A, Siciliano R, Valenti P, Antonini G ' 'et al (2003) Heparin-interacting sites of bovine lactoferrin are ' 'involved in anti-adenovirus activity. J Med Virol 69(4):495–502', 'journal-title': 'J Med Virol'}, { 'issue': '1', 'key': '477_CR9', 'doi-asserted-by': 'publisher', 'first-page': '63', 'DOI': '10.1016/j.antiviral.2004.05.005', 'volume': '64', 'author': 'P Drobni', 'year': '2004', 'unstructured': 'Drobni P, Näslund J, Evander M (2004) Lactoferrin inhibits human ' 'papillomavirus binding and uptake in vitro. Antivir Res 64(1):63–68', 'journal-title': 'Antivir Res'}, { 'key': '477_CR10', 'doi-asserted-by': 'publisher', 'first-page': '562', 'DOI': '10.1016/S0140-6736(21)00242-7', 'volume': '397', 'author': 'JP Figueroa', 'year': '2021', 'unstructured': 'Figueroa JP, Bottazzi ME, Hotez P, Batista C, Ergonul O, Gilbert S et al ' '(2021) Urgent needs of low-income and middle-income countries for ' 'COVID-19 vaccines and therapeutics. Lancet 397:562–564', 'journal-title': 'Lancet'}, { 'key': '477_CR11', 'doi-asserted-by': 'crossref', 'unstructured': 'Hanson KE, Caliendo AM, Arias CA, Englund JA, Lee MJ, Loeb M et al ' '(2020) Infectious Diseases Society of America guidelines on the ' 'diagnosis of COVID-19. www.idsociety.org/COVID19guidelines/dx. Accessed ' '29 June 2021', 'DOI': '10.1093/cid/ciab048'}, { 'issue': '2', 'key': '477_CR12', 'doi-asserted-by': 'publisher', 'first-page': '377', 'DOI': '10.1016/j.jbi.2008.08.010', 'volume': '42', 'author': 'PA Harris', 'year': '2009', 'unstructured': 'Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) ' 'Research electronic data capture (REDCap)—a metadata-driven methodology ' 'and workflow process for providing translational research informatics ' 'support. J Biomed Inform 42(2):377–381', 'journal-title': 'J Biomed Inform'}, { 'key': '477_CR13', 'doi-asserted-by': 'publisher', 'first-page': '103208', 'DOI': '10.1016/j.jbi.2019.103208', 'volume': '95', 'author': 'PA Harris', 'year': '2019', 'unstructured': 'Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L et al ' '(2019) The REDCap consortium: building an international community of ' 'software platform partners. J Biomed Inform 95:103208', 'journal-title': 'J Biomed Inform'}, { 'issue': '4', 'key': '477_CR14', 'doi-asserted-by': 'publisher', 'first-page': '791', 'DOI': '10.1016/j.bbrc.2013.04.013', 'volume': '434', 'author': 'H Ishikawa', 'year': '2013', 'unstructured': 'Ishikawa H, Awano N, Fukui T, Sasaki H, Kyuwa S (2013) The protective ' 'effects of lactoferrin against murine norovirus infection through ' 'inhibition of both viral attachment and replication. Biochem Biophys Res ' 'Commun 434(4):791–796', 'journal-title': 'Biochem Biophys Res Commun'}, { 'issue': '8', 'key': '477_CR15', 'doi-asserted-by': 'publisher', 'first-page': '23710', 'DOI': '10.1371/journal.pone.0023710', 'volume': '6', 'author': 'J Lang', 'year': '2011', 'unstructured': 'Lang J, Yang N, Deng J, Liu K, Yang P, Zhang G et al (2011) Inhibition ' 'of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate ' 'proteoglycans. PLoS ONE 6(8):23710', 'journal-title': 'PLoS ONE'}, { 'key': '477_CR16', 'doi-asserted-by': 'publisher', 'first-page': 'S10', 'DOI': '10.1016/j.jpeds.2016.02.071', 'volume': '173', 'author': 'D Legrand', 'year': '2016', 'unstructured': 'Legrand D (2016) Overview of lactoferrin as a natural immune modulator. ' 'J Pediatr 173:S10–S15', 'journal-title': 'J Pediatr'}, { 'key': '477_CR17', 'doi-asserted-by': 'publisher', 'first-page': '435', 'DOI': '10.1134/S0003683816040116', 'volume': '52', 'author': 'AR Lizzi', 'year': '2016', 'unstructured': 'Lizzi AR, Carnicelli V, Clarkson MM et al (2016) Bovine lactoferrin and ' 'its tryptic peptides: antibacterial activity against different species. ' 'Appl Biochem Microbiol 52:435–440. ' 'https://doi.org/10.1134/S0003683816040116', 'journal-title': 'Appl Biochem Microbiol'}, { 'issue': '1', 'key': '477_CR18', 'doi-asserted-by': 'publisher', 'first-page': '405', 'DOI': '10.1016/j.virol.2003.09.029', 'volume': '318', 'author': 'M Marchetti', 'year': '2004', 'unstructured': 'Marchetti M, Trybala E, Superti F, Johansson M, Bergström T (2004) ' 'Inhibition of herpes simplex virus infection by lactoferrin is dependent ' 'on interference with the virus binding to glycosaminoglycans. Virology ' '318(1):405–413', 'journal-title': 'Virology'}, { 'key': '477_CR19', 'doi-asserted-by': 'publisher', 'author': 'H Oda', 'year': '2020', 'unstructured': 'Oda H, Wakabayashi H, Tanaka M, Yamauchi K, Sugita C, Yoshida H et al ' '(2020) Effects of lactoferrin on infectious diseases in Japanese summer: ' 'a randomized, double-blinded, placebo-controlled trial. J Microbiol ' 'Immunol Infect. https://doi.org/10.1016/j.jmii.2020.02.010', 'journal-title': 'J Microbiol Immunol Infect', 'DOI': '10.1016/j.jmii.2020.02.010'}, { 'issue': '1', 'key': '477_CR20', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1186/1471-2172-6-2', 'volume': '6', 'author': 'R Reghunathan', 'year': '2005', 'unstructured': 'Reghunathan R, Jayapal M, Hsu LY, Chng HH, Tai D, Leung BP et al (2005) ' 'Expression profile of immune response genes in patients with severe ' 'acute respiratory syndrome. BMC Immunol 6(1):1–11', 'journal-title': 'BMC Immunol'}, { 'issue': '1', 'key': '477_CR21', 'first-page': '08', 'volume': '8', 'author': 'G Serrano', 'year': '2020', 'unstructured': 'Serrano G, Kochergina I, Albors A, Diaz E, Oroval M, Hueso G et al ' '(2020) Liposomal lactoferrin as potential preventative and cure for ' 'COVID-19. Int J Res Health Sci 8(1):08–15', 'journal-title': 'Int J Res Health Sci'}, { 'key': '477_CR22', 'doi-asserted-by': 'publisher', 'author': 'ASV Shah', 'year': '2020', 'unstructured': 'Shah ASV, Wood R, Gribben C, Caldwell D, Bishop J, Weir A et al (2020) ' 'Risk of hospital admission with coronavirus disease 2019 in healthcare ' 'workers and their households: nationwide linkage cohort study. BMJ. ' 'https://doi.org/10.1136/bmj.m3582', 'journal-title': 'BMJ', 'DOI': '10.1136/bmj.m3582'}, { 'issue': '2–3', 'key': '477_CR23', 'doi-asserted-by': 'publisher', 'first-page': '107', 'DOI': '10.1016/S0304-4165(01)00178-7', 'volume': '1528', 'author': 'F Superti', 'year': '2001', 'unstructured': 'Superti F, Siciliano R, Rega B, Giansanti F, Valenti P, Antonini G ' '(2001) Involvement of bovine lactoferrin metal saturation, sialic acid ' 'and protein fragments in the inhibition of rotavirus infection. Biochim ' 'Biophys Acta 1528(2–3):107–115', 'journal-title': 'Biochim Biophys Acta'}, { 'issue': '3', 'key': '477_CR24', 'doi-asserted-by': 'publisher', 'first-page': '164', 'DOI': '10.1016/j.ctim.2012.12.006', 'volume': '21', 'author': 'L Vitetta', 'year': '2013', 'unstructured': 'Vitetta L, Coulson S, Beck SL, Gramotnev H, Du S, Lewis S (2013) The ' 'clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction ' '(Lf/IgF) for the common cold: a double blind randomized study. ' 'Complement Ther Med 21(3):164–171', 'journal-title': 'Complement Ther Med'}, { 'key': '477_CR25', 'unstructured': 'World Health Organization (WHO) (2021) COVID-19 clinical management: ' 'living guidance. ' 'https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1. ' 'Accessed 16 May 2021'}], 'container-title': 'BioMetals', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s10534-022-00477-3.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s10534-022-00477-3/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s10534-022-00477-3.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 8]], 'date-time': '2022-12-08T14:29:57Z', 'timestamp': 1670509797000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s10534-022-00477-3'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 12, 7]]}, 'references-count': 25, 'alternative-id': ['477'], 'URL': 'http://dx.doi.org/10.1007/s10534-022-00477-3', 'relation': {}, 'ISSN': ['0966-0844', '1572-8773'], 'subject': [ 'Metals and Alloys', 'General Agricultural and Biological Sciences', 'General Biochemistry, Genetics and Molecular Biology', 'Biomaterials'], 'container-title-short': 'Biometals', 'published': {'date-parts': [[2022, 12, 7]]}, 'assertion': [ { 'value': '30 March 2022', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '24 November 2022', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '7 December 2022', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'All authors have no conflict of interest.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}