"Association Study of Aspirin and Atorvastatin with Covid-19 Hospitalization: A Retrospective Longitudinal Study in Tehran"
Seyed Kianoosh, Hossein Lanjanian, Bita Shalbafan, Fatemeh Abdi, Maryam S Daneshpour, J Biomed, Tech Sci, Res
Biomedical Journal of Scientific & Technical Research, doi:10.26717/bjstr.2023.48.007623
COVID-19 threat is unlikely to fade soon since Global vaccination, as the best solution, is not being quickly realized. Thus, pre-exposure prophylaxis would be an available alternative strategy. This longitudinal retrospective study was done on 7696 patients referred to an Iranian hospital in the south of Tehran. The PCR result for COVID-19 and history of medications were gathered from the hospital HIS system. We investigated the possible chemoprophylaxis of the routinely recommend drugs for atherosclerosis risk control. Whit the aim of extracting the association of the pre-exposure drug history and COVID-19 history, the logistic regression model was used by adjusting for age, sex, and drug history six months before and after the pandemic. A total of 7696 individuals (12-97 yrs), 3272 men (63±14 yrs), and 4424 women (62±13.4 yrs) were studied. Among them, 581(7%) with the COVID-19 infection; 575(7%) with a hospitalization history in 6 months before the pandemic; 5809(75%) with hypertension; 2428(32%) with Ischemic Heart Disease; 2323(30%) with diabetes mellitus; 2068(26%) on metformin; 4132(54%) on Atorvastatin; 4852(62%) on Aspirin; 3907(50%) on ARBs; 638 (8%) on ACEIs; multivariable regression analysis demonstrated the strong association between pre-exposure ASA or Atorvastatin consumption and hospitalization rate due to COVID-19 as an infection severity index. Moreover, COVID-19 hospitalization rates were decreased in female hypertensive cases with ARB in their drug histories. In hypertensive subjects, comorbidity of diabetes mellitus and HTN increase the COVID-19 hospitalization rate in men by 2 .930. Someone at risk of COVID-19 infection should control their blood pressure and hyperglycemia precisely, and not only strict BP and BS control but also, Aspirin and Atorvastatin as chemoprophylaxis is highly recommended. Even the overprotection and increasing self-care during an illness may also affect the exposure to the infection.
Declarations of interest None.
Ethics Approval and Consent to Participate All procedures were under the ethics committee's ethical standards on human subject research at Shahid Beheshti University of Medical Sciences (IR.SBMU.RETECH.REC.1399.576; 12. Oct.2020). The Social Security Patient Support Committee has given us access to information and they have supervised the data collection process. Of course, this information did not contain the identities of the individuals, and each person was identified by a unique code. Since, we did not do any interventions in the treatment process of individuals and only the database and registered documents were used, there is no need for consent. We confirm that all procedures are performed in accordance with the relevant instructions.
Submission Declaration and Verification We declare that this manuscript is original, has not been published before, and is not currently being considered for publication elsewhere.
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