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All Studies   Meta Analysis    Recent:   

Serum vitamin D level in COVID-19 patients and its correlation with disease severity

Morad et al., Egyptian Rheumatology and Rehabilitation, doi:10.1186/s43166-022-00155-9
Oct 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 80 COVID-19 patients in Egypt, showing lower vitamin D levels associated with mechanical ventilation and mortality.
Morad et al., 7 Oct 2022, Egypt, peer-reviewed, mean age 52.0, 4 authors, study period June 2021 - December 2021. Contact: carolinesamy@yahoo.com (corresponding author).
This PaperVitamin DAll
Serum vitamin D level in COVID-19 patients and its correlation with disease severity
Caroline S Morad, Reem A Habeeb, Esraa T Yassin, Salma A Khalil
Egyptian Rheumatology and Rehabilitation, doi:10.1186/s43166-022-00155-9
Background: Severe coronavirus disease 2019 (COVID-19) infections are associated with increased levels of C-reactive protein (CRP) and several pro-inflammatory cytokines leading to cytokine storm. Vitamin D has been proved to be associated with biological activities of the innate and adaptive immune systems. There is a growing number of data showing an association between serum vitamin D level and the different clinical outcomes of COVID-19 infection. Our aim is to evaluate the relation between serum vitamin D levels and the severity and mortality of COVID-19 infection in an Egyptian cohort. Results: The study included 80 COVID-19 patients, 38 males (47.5%) and 42 females (52.5%), with a mean age of 52 ± 11.4 years (18-80 years). The serum vitamin D levels ranged between 2 and 30 ng/mL with a mean of 12.05 ± 9.04. Patients who were intubated had the lowest levels of serum vitamin D (7.26 ng/ml ± 5.21), while patients who had no need for oxygen supply had the highest levels (20.00 ng/ml ± 9.23) (P = 0.025). A highly significant negative correlation was found between serum vitamin D level and each of CRP and serum ferritin (r = − 0.346 and − 0.313) (P = 0.002 and 0.005). Of the enrolled 80 patients, 63 (79%) recovered (group 1) and 17 (21%) died (group 2). Group 2 had significantly lower vitamin D levels (6.17 ng/mL ± 3.22) and hemoglobin (10.75 ± 1.74) than group 1 patients (13.63ng/mL ± 9.46) (12.10 ± 1.85) (P = 0.002 and 0.009 respectively). Conclusion: Serum vitamin D levels are significantly lower in patients needing mechanical ventilation, and in deceased patients, and are inversely related to the inflammatory markers CRP and serum ferritin, suggesting a relation between vitamin D insufficiency and poor COVID-19 outcome.
Abbreviations Declarations Ethics approval and consent to participate The study was approved by the Ain Shams University, Faculty of Medicine Research Ethics Committee (REC) FWA 000017585. An informed written consent was taken from patients enrolled in the study. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Nutr J 20(1):89', 'journal-title': 'Nutr J'}, { 'key': '155_CR26', 'doi-asserted-by': 'publisher', 'first-page': '264', 'DOI': '10.1016/j.ijid.2021.04.083', 'volume': '107', 'author': 'M Nasiri', 'year': '2021', 'unstructured': 'Nasiri M, Khodadadi J, Molaei S (2021) Does vitamin D serum level affect ' 'prognosis of COVID-19 patients? Int J Infect Dis. 107:264–267', 'journal-title': 'Int J Infect Dis.'}, { 'key': '155_CR27', 'doi-asserted-by': 'publisher', 'unstructured': 'Lin LY, Mulick A, Mathur R, Smeeth L, Warren-Gash C, Langan SM (2022) ' 'The association between vitamin D status and COVID-19 in England: A ' 'cohort study using UK Biobank. PLoS One 17(6):e0269064. Published 2022 ' 'Jun 6. https://doi.org/10.1371/journal.pone.0269064', 'DOI': '10.1371/journal.pone.0269064'}, { 'issue': '1', 'key': '155_CR28', 'doi-asserted-by': 'publisher', 'first-page': '574', 'DOI': '10.1186/s12879-021-06277-3', 'volume': '21', 'author': 'B Zhu', 'year': '2021', 'unstructured': 'Zhu B, Feng X, Jiang C, Mi S, Yang L, Zhao Z et al (2021) Correlation ' 'between white blood cell count at admission and mortality in COVID-19 ' 'patients: a retrospective study. BMC Infect Dis. 21(1):574', 'journal-title': 'BMC Infect Dis.'}, { 'issue': '1', 'key': '155_CR29', 'doi-asserted-by': 'publisher', 'first-page': '170', 'DOI': '10.1186/s12879-021-05868-4', 'volume': '21', 'author': 'M Faghih Dinevari', 'year': '2021', 'unstructured': 'Faghih Dinevari M, Somi MH, Sadeghi Majd E, Abbasalizad Farhangi M, ' 'Nikniaz Z (2021) Anemia predicts poor outcomes of COVID-19 in ' 'hospitalized patients: a prospective study in Iran. BMC Infect Dis. ' '21(1):170', 'journal-title': 'BMC Infect Dis.'}], 'container-title': 'Egyptian Rheumatology and Rehabilitation', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s43166-022-00155-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s43166-022-00155-9/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s43166-022-00155-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 10, 7]], 'date-time': '2022-10-07T00:04:44Z', 'timestamp': 1665101084000}, 'score': 1, 'resource': {'primary': {'URL': 'https://erar.springeropen.com/articles/10.1186/s43166-022-00155-9'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 10, 7]]}, 'references-count': 29, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2022, 12]]}}, 'alternative-id': ['155'], 'URL': 'http://dx.doi.org/10.1186/s43166-022-00155-9', 'relation': {}, 'ISSN': ['1110-161X', '2090-3235'], 'subject': [ 'Industrial and Manufacturing Engineering', 'Materials Science (miscellaneous)', 'Business and International Management', 'General Earth and Planetary Sciences', 'General Environmental Science'], 'container-title-short': 'Egypt Rheumatol Rehabil', 'published': {'date-parts': [[2022, 10, 7]]}, 'assertion': [ { 'value': '23 August 2022', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '23 September 2022', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '7 October 2022', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The study was approved by the Ain Shams University, Faculty of Medicine ' 'Research Ethics Committee (REC) FWA 000017585. An informed written consent was ' 'taken from patients enrolled in the study.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '55'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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