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Lysosomotropic properties of sodium bicarbonate and COVID-19

Mir et al., Farmacia, doi:10.31925/farmacia.2020.5.1
Oct 2020  
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Review exploring the use of sodium bicarbonate as a lysosomotropic agent against SARS-CoV-2 based on its widespread use during the 1918 Spanish flu pandemic. Authors suggest that the careful use of sodium bicarbonate could help restrain SARS-CoV-2 infection by countering the acidic pH required for viral entry and reproduction in host cells.
See Rashedi et al. for another review covering sodium bicarbonate for COVID-19.
Mir et al., 27 Oct 2020, India, peer-reviewed, 1 author. Contact: parvaizbot@yahoo.com.
This PaperSodium Bicarb..All
LYSOSOMOTROPIC PROPERTIES OF SODIUM BICARBONATE AND COVID-19
Mudasir A Mir, Abida Bhat, Ajaz Ahmad, Parvaiz Ahmad
FARMACIA, doi:10.31925/farmacia.2020.5.1
SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. SARS-Cov-2 entrance into the host cells is reliant on acidic pH. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbonate as an alternative lysosomotropic agent based on the reported literature owing to its anti-flu properties and widespread use during 1918 Spanish flu pandemic. The suggestions put forward in the current review article based on the careful use of sodium bicarbonate could probably help to restrain SARS-CoV-2 infection. Rezumat COVID-19 a generat o criză de sănătate publică globală cu consecințe uriașe până în prezent, în principal din cauza lipsei agenților terapeutici specifici. Pătrunderea SARS-Cov-2 în celulele gazdă depinde de pH-ul acid. Astfel, în situația clinică actuală este nevoie de terapii adjuvante care ar putea contracara pH-ul acid, pentru a limita penetrarea virusului la nivel celular. Prin urmare, studiul de față explorează posibilitatea utilizării bicarbonatului de sodiu ca agent lizozomotrop alternativ, pe baza datelor referitoare la gripa spaniolă din 1918. Sugestiile prezentate în actualul articol, privind utilizarea bicarbonatului de sodiu, ar putea ajuta contribui la limitarea infecțiilor cu SARS-CoV-2.
Conflict of interest The authors declare no conflict of interest.
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