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Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress

Maradi et al., Reports of Biochemistry & Molecular Biology, 11:3
Oct 2022  
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Zinc for COVID-19
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*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
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4,000+ studies for 60+ treatments.
Retrospective 100 COVID-19 patients and 100 healthy controls in India, showing significantly lower zinc levels in COVID-19 patients.
Maradi et al., 31 Oct 2022, retrospective, India, peer-reviewed, 5 authors.
This PaperZincAll
Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress
Ravindra Maradi, Vivek Joshi, Vaideki Balamurugan, Divya Susan Thomas, Manjunath B Goud
Background: COVID-19 is caused by the Severe Acute Respiratory Distress Syndrome Coronavirus 2. Since the antioxidant mechanisms such as glutathione peroxidase or superoxide dismutase are downregulated during infection by the virus, there is an imbalance in the oxidant-antioxidant system. In this study we aimed to identify the effect of COVID-19 on the antioxidant defense mechanism by comparing the concentrations of antioxidants and microminerals in COVID-19 patients and healthy controls. Methods: This cross-sectional analytical study involved 200 patients at Kasturba Hospital, Manipal University. The serum concentrations of antioxidants and minerals were determined to establish the impact of COVID-19 on antioxidants mechanism and nutrient status in COVID-19 patients. Results: The serum concentrations of GPX (10.36 ± 2.70 ≥ 5.82 ± 1.64 mKAT/L, p < 0.0001) and copper (2192.5 ± 449.8 ≥ 782.15 ± 106.5 µg/dL, p < 0.0001) were significantly greater, and zinc (34.78 ± 4.5 ≤ 81.07 ± 10.13 µg/dL, p < 0.0001) was significantly less, in the study group than in controls. The Pearson correlation between serum SOD and zinc was significant (r = 0.491, p < 0.0001) indicating the importance of zinc in maintaining and improving SOD activity. No significant correlations were observed between copper and SOD (r = -0.089) or iron and CAT (r = -0.027). Conclusions: Our study demonstrated the expected increase in oxidant-radical production during COVID-19 by estimating the altered concentrations of antioxidants and the minerals required to neutralize the elevated ROS. This finding is not novel but adds to the existing literature, which recommends nutritional supplementation of microminerals and antioxidants.
Conflict of Interest There is no conflict of interest with anyone. Ethical Approval The study was carried out after obtaining approval from the Institutional Ethics Committee, Kasturba Hospital, Manipal. The first participant in the study was enrolled after registration in the Clinical Trial Registration of India.
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