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Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19

Malinowska et al., International Journal of Molecular Sciences, doi:10.3390/ijms22041986
Feb 2021  
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Review of the potential benefits and concerns for the use of cannabidiol in the treatment of COVID-19.
Malinowska et al., 17 Feb 2021, peer-reviewed, 4 authors.
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Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19
Barbara Malinowska, Marta Baranowska-Kuczko, Aleksandra Kicman, Eberhard Schlicker
International Journal of Molecular Sciences, doi:10.3390/ijms22041986
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to coronavirus disease 2019 (COVID-19) which, in turn, may be associated with multiple organ dysfunction. In this review, we present advantages and disadvantages of cannabidiol (CBD), a non-intoxicating phytocannabinoid from the cannabis plant, as a potential agent for the treatment of COVID-19. CBD has been shown to downregulate proteins responsible for viral entry and to inhibit SARS-CoV-2 replication. Preclinical studies have demonstrated its effectiveness against diseases of the respiratory system as well as its cardioprotective, nephroprotective, hepatoprotective, neuroprotective and anti-convulsant properties, that is, effects that may be beneficial for COVID-19. Only the latter two properties have been demonstrated in clinical studies, which also revealed anxiolytic and antinociceptive effects of CBD (given alone or together with ∆ 9 -tetrahydrocannabinol), which may be important for an adjuvant treatment to improve the quality of life in patients with COVID-19 and to limit post-traumatic stress symptoms. However, one should be aware of side effects of CBD (which are rarely serious), drug interactions (also extending to drugs acting against COVID-19) and the proper route of its administration (vaping may be dangerous). Clearly, further clinical studies are necessary to prove the suitability of CBD for the treatment of COVID-19.
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Only the latter two properties have been ' 'demonstrated in clinical studies, which also revealed anxiolytic and antinociceptive effects ' 'of CBD (given alone or together with Δ9-tetrahydrocannabinol), which may be important for an ' 'adjuvant treatment to improve the quality of life in patients with COVID-19 and to limit ' 'post-traumatic stress symptoms. However, one should be aware of side effects of CBD (which ' 'are rarely serious), drug interactions (also extending to drugs acting against COVID-19) and ' 'the proper route of its administration (vaping may be dangerous). Clearly, further clinical ' 'studies are necessary to prove the suitability of CBD for the treatment of COVID-19.</jats:p>', 'alternative-id': ['ijms22041986'], 'author': [ {'affiliation': [], 'family': 'Malinowska', 'given': 'Barbara', 'sequence': 'first'}, {'affiliation': [], 'family': 'Baranowska-Kuczko', 'given': 'Marta', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kicman', 'given': 'Aleksandra', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Schlicker', 'given': 'Eberhard', 'sequence': 'additional'}], 'container-title': ['International Journal of Molecular Sciences'], 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2021, 2, 18]], 'date-time': '2021-02-18T02:35:42Z', 'timestamp': 1613615742000}, 'deposited': { 'date-parts': [[2021, 2, 25]], 'date-time': '2021-02-25T02:51:16Z', 'timestamp': 1614221476000}, 'funder': [ { 'DOI': '10.13039/501100005297', 'award': ['N/ST/ZB/16/003/2213, N/ST/ZB/17/001/2213 and 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